In this dissertation a computationally efficient cognitive multiple-input multiple-output (MIMO) orthogonal frequency division duplexing (OFDM) detector is designed to decode perfect space-time coded signals which are able maximize the diversity and multiplexing properties of a rich fading MIMO channel. The adaptive nature of the cognitive detector allows a MIMO OFDM communication system to better meet to needs of future wireless communication networks which require both high reliability and low run-time complexity depending on the propagation environment. The cognitive detector in conjunction with perfect space-time coding is able to achieve up to a 2 dB bit-error rate (BER) improvement at low signal-to-noise ratio (SNR) while also achieving comparable runtime complexity in high SNR scenarios.