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Lipopolysaccharide Challenge Reveals Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Murine Systemic Lupus Erythematosus
Study explores whether chronic inflammatory processes in systemic lupus erythematosus (SLE) are in part due to hypothalamic-pituitary-adrenal (HPA) axis dysfunction by challenging female control and SLE mice with lipopolysaccharide (LPS) and measuring c-Fos expression as an index of neuronal activation, plasma adrenocorticotrophic hormone (ACTH) as an index of anterior pituitary function, and plasma corticosterone as an index of adrenal function.
Date:
October 4, 2018
Creator:
Pham, Grace S. & Mathis, Keisa W.
System:
The UNT Digital Library