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Genome-Wide Identification and 3D Modeling of Proteins involved in DNA Damage Recognition and Repair (Final Report) (open access)

Genome-Wide Identification and 3D Modeling of Proteins involved in DNA Damage Recognition and Repair (Final Report)

DNA Damage Recognition and Repair (DDR&R) proteins play a critical role in cellular responses to low-dose radiation and are associated with cancer. We have performed a systematic, genome-wide computational analysis of genomic data for human genes involved in the DDR&R process. The significant achievements of this project include: 1) Construction of the computational pipeline for searching DDR&R genes, building and validation of 3D models of proteins involved in DDR&R; 2) Functional and structural annotation of the 3D models and generation of comprehensive lists of suggested knock-out mutations; and the development of a method to predict the effects of mutations. Large scale testing of technology to identify novel small binding pockets in protein structures leading to new DDRR inhibitor strategies 3) Improvements of macromolecular docking technology (see the CAPRI 1-3 and 4-5 results) 4) Development of a new algorithm for improved analysis of high-density oligonucleotide arrays for gene expression profiling; 5) Construction and maintenance of the DNA Damage Recognition and Repair Database; 6) Producing 15 research papers (12 published and 3 in preparation).
Date: August 12, 2005
Creator: Abagyan, Ruben & An, Jianghong
Object Type: Report
System: The UNT Digital Library
Ion Deflection for Final Optics in Laser Inertial Fusion Power Plants (open access)

Ion Deflection for Final Optics in Laser Inertial Fusion Power Plants

Left unprotected, both transmissive and reflective final optics in a laser-driven inertial fusion power plant would quickly fail from melting, pulsed thermal stress, or degradation of optical properties as a result of ion implantation. One potential option for mitigating this threat is to magnetically deflect the ions such that they are directed to a robust energy dump. In this paper we detail integrated studies that have been carried out to assess the viability of this approach for protecting final optics.
Date: December 12, 2005
Creator: Abbott, R P
Object Type: Thesis or Dissertation
System: The UNT Digital Library
Top physics: search for electroweak single top quark production in p anti-p collisions at s**(1/2) = 1.96 tev (open access)

Top physics: search for electroweak single top quark production in p anti-p collisions at s**(1/2) = 1.96 tev

We report on a search for Standard Model t-channel and s-channel single top quark production in p{bar p} collisions at a center of mass energy of 1.96 TeV. We use a data sample corresponding to 162 pb{sup -1} recorded by the upgraded Collider Detector at Fermilab. We find no significant evidence for electroweak top quark production and set upper limits at the 95% confidence level on the production cross section, consistent with the Standard Model: 10.1 pb for the t-channel, 13.6 pb for the s-channel and 17.8 pb for the combined cross section of t- and s-channel.
Date: January 12, 2005
Creator: Acosta, D.
Object Type: Report
System: The UNT Digital Library
Pseudorapidity Asymmetry and Centrality Dependence of Charged Hadron Spectra in d+Au collisions at sqrt(sNN) = 200 GeV (open access)

Pseudorapidity Asymmetry and Centrality Dependence of Charged Hadron Spectra in d+Au collisions at sqrt(sNN) = 200 GeV

The pseudorapidity asymmetry and centrality dependence of charged hadron spectra in d+Au collisions at {radical}s{sub NN} = 200 GeV are presented. The charged particle density at mid-rapidity, its pseudorapidity asymmetry and centrality dependence are reasonably reproduced by a Multi-Phase Transport model, by HIJING, and by the latest calculations in a saturation model. Ratios of transverse momentum spectra between backward and forward pseudorapidity are above unity for p{sub T} below 5 GeV/c. The ratio of central to peripheral spectra in d+Au collisions shows enhancement at 2 < p{sub T} < 6 GeV/c, with a larger effect at backward rapidity than forward rapidity. Our measurements are in qualitative agreement with gluon saturation and in contrast to calculations based on incoherent multiple partonic scatterings.
Date: January 12, 2005
Creator: Adams, J.; Aggarwal, M. M.; Ahammed, Z.; Amonett, J.; Anderson, B. D.; Arkhipkin, D. et al.
Object Type: Article
System: The UNT Digital Library
Timpson & Tenaha News (Timpson, Tex.), Vol. 20, No. 18, Ed. 1 Thursday, May 12, 2005 (open access)

Timpson & Tenaha News (Timpson, Tex.), Vol. 20, No. 18, Ed. 1 Thursday, May 12, 2005

Weekly newspaper from Timpson, Texas that includes local, state, and national news along with advertising.
Date: May 12, 2005
Creator: Alexander, Nancy
Object Type: Newspaper
System: The Portal to Texas History
On the Significance of the Contribution of Multiple-Electron Capture Processes to Cometary X-Ray Emission (open access)

On the Significance of the Contribution of Multiple-Electron Capture Processes to Cometary X-Ray Emission

We report laboratory studies of the role played by multiple-electron capture (MEC) in solar wind induced cometary X-ray emission. Collisions of Ne{sup 10+} with He, Ne, Ar, CO, and CO{sub 2} have been investigated by means of the traditional singles X-ray spectroscopy in addition to the triple-coincidence measurements of X-rays, scattered projectile, and target recoil ions for the atomic targets. The coincidence measurements enable the reduction of the singles X-ray spectra into partial spectra originating in single-electron capture (SEC) and MEC collisions. The measurements provide unequivocal evidence for a significant role played by MEC, and strongly suggest that models based solely on SEC are bound to yield erroneous conclusions on the solar wind composition and velocities and on cometary atmospheres. The experimental relative importance of MEC collisions is compared with molecular classical-over-the-barrier model (MCBM), classical trajectory Monte Carlo (CTMC), and multi-channel Landau-Zener (MCLZ), calculations which can qualitatively reproduce the experimental trends.
Date: May 12, 2005
Creator: Ali, R.; Neill, P. A.; Beiersdorfer, P.; Harris, C. L.; Rakovi?, M. J.; Wang, J. G. et al.
Object Type: Article
System: The UNT Digital Library
Altus Times (Altus, Okla.), Vol. 106, No. 238, Ed. 1 Wednesday, January 12, 2005 (open access)

Altus Times (Altus, Okla.), Vol. 106, No. 238, Ed. 1 Wednesday, January 12, 2005

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date: January 12, 2005
Creator: Andrews, Mike
Object Type: Newspaper
System: The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 107, No. 10, Ed. 1 Tuesday, April 12, 2005 (open access)

Altus Times (Altus, Okla.), Vol. 107, No. 10, Ed. 1 Tuesday, April 12, 2005

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date: April 12, 2005
Creator: Andrews, Mike
Object Type: Newspaper
System: The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 107, No. 36, Ed. 1 Thursday, May 12, 2005 (open access)

Altus Times (Altus, Okla.), Vol. 107, No. 36, Ed. 1 Thursday, May 12, 2005

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date: May 12, 2005
Creator: Andrews, Mike
Object Type: Newspaper
System: The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 107, No. 60, Ed. 1 Sunday, June 12, 2005 (open access)

Altus Times (Altus, Okla.), Vol. 107, No. 60, Ed. 1 Sunday, June 12, 2005

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date: June 12, 2005
Creator: Andrews, Mike
Object Type: Newspaper
System: The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 107, No. 86, Ed. 1 Tuesday, July 12, 2005 (open access)

Altus Times (Altus, Okla.), Vol. 107, No. 86, Ed. 1 Tuesday, July 12, 2005

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date: July 12, 2005
Creator: Andrews, Mike
Object Type: Newspaper
System: The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 107, No. 113, Ed. 1 Friday, August 12, 2005 (open access)

Altus Times (Altus, Okla.), Vol. 107, No. 113, Ed. 1 Friday, August 12, 2005

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date: August 12, 2005
Creator: Andrews, Mike
Object Type: Newspaper
System: The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 107, No. 139, Ed. 1 Monday, September 12, 2005 (open access)

Altus Times (Altus, Okla.), Vol. 107, No. 139, Ed. 1 Monday, September 12, 2005

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date: September 12, 2005
Creator: Andrews, Mike
Object Type: Newspaper
System: The Gateway to Oklahoma History
Performance of 2nd Generation BaBar Resistive Plate Chambers (open access)

Performance of 2nd Generation BaBar Resistive Plate Chambers

The BaBar detector has operated nearly 200 Resistive Plate Chambers (RPCs), constructed as part of an upgrade of the forward endcap muon detector, for the past two years. The RPCs experience widely different background and luminosity-driven singles rates (0.01-10 Hz/cm{sup 2}) depending on position within the endcap. Some regions have integrated over 0.3 C/cm{sup 2}. RPC efficiency measured with cosmic rays is high and stable. The average efficiency measured with beam is also high. However, a few of the highest rate RPCs have suffered efficiency losses of 5-15%. Although constructed with improved techniques and minimal use of linseed oil, many of the RPCs, which are operated in streamer mode, have shown increased dark currents and noise rates that are correlated with the direction of the gas flow and the integrated current. Studies of the above aging effects are presented and correlated with detector operating conditions.
Date: July 12, 2005
Creator: Anulli, F.; Baldini, R.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Patteri, P. et al.
Object Type: Article
System: The UNT Digital Library
U.S.-EU Cooperation Against Terrorism (open access)

U.S.-EU Cooperation Against Terrorism

None
Date: July 12, 2005
Creator: Archick, Kristin
Object Type: Report
System: The UNT Digital Library
NATO and the European Union (open access)

NATO and the European Union

Report which discusses issues related to the North Atlantic Trade Organization (NATO) and the European Union (EU) including the level of involvement of the entities in using political and military actions to defend against terrorism and proliferation, the types of military forces necessary, the role of the EU in crisis management, the appropriateness of decision-making procedures to respond to emerging threats, and the role of other international institutions.
Date: May 12, 2005
Creator: Archick, Kristin & Gallis, Paul E.
Object Type: Report
System: The UNT Digital Library
Dalitz Plot Analysis of D0 to K0K+ K- (open access)

Dalitz Plot Analysis of D0 to K0K+ K-

A Dalitz plot analysis of approximately 12,500 D{sup 0} events reconstructed in the hadronic decay D{sup 0} {yields} {bar K}{sup 0} K{sup +}K{sup -} is presented. This analysis is based on a data sample of 91.5 fb{sup -1} collected with the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} storage rings at SLAC running at center-of-mass energies on and 40 MeV below the {Upsilon}(4S) resonance. The events are selected from e{sup +}e{sup -} {yields} c{bar c} annihilations using the decay D*{sup +} {yields} D{sup 0}{pi}{sup +}. The following ratio of branching fractions has been obtained: BR = {Lambda}(D{sup 0} {yields} {bar K}{sup 0}K{sup +}K{sup -})/{Lambda}(D{sup 0} {yields} {bar K}{sup 0}{pi}{sup +}{pi}{sup -}) = (15.8 {+-} 0.1(stat.) {+-} 0.5 (syst.)) x 10{sup -2}. Estimates of fractions and phases for resonant and non-resonant contributions to the Dalitz plot are also presented. The a{sub 0}(980) {yields} {bar K}K projection has been extracted with little background. A search for Cp asymmetries on the Dalitz plot has been performed.
Date: July 12, 2005
Creator: Aubert, B.; Barate, R.; Boutigny, D.; Couderc, F.; Karyotakis, Y.; Lees, J. P. et al.
Object Type: Article
System: The UNT Digital Library
Evidence for B+ to K0barK+ and B0 to K0K0bar, and Measurement of the Branching Fraction and Search for Direct CP Violation in B+ to K0pi+ (open access)

Evidence for B+ to K0barK+ and B0 to K0K0bar, and Measurement of the Branching Fraction and Search for Direct CP Violation in B+ to K0pi+

The authors present evidence for the b {yields} d penguin-dominated decays B{sup +} {yields} {bar K}{sup 0}K{sup +} and B{sup 0} {yields} K{sup 0}{bar K}{sup 0} with significances of 3.5 and 4.5 standard deviations, respectively. The results are based on a sample of 227 million {Upsilon}(4S) {yields} B{bar B} decays collected with the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} collider at SLAC. We measure the branching fractions {Beta}(B{sup +} {yields} {bar K}{sup 0}K{sup +}) = (1.5 {+-} 0.5 {+-} 0.1) x 10{sup -6} (< 2.4 x 10{sup -6}) and {Beta}(B{sup 0} {yields} K{sup 0}{bar K}{sup 0}) = (1.19{sub -0.35}{sup +0.40} {+-} 0.13) x 10{sup -6}, where the uncertainties are statistical and systematic, respectively, and the upper limit on the branching fraction for {bar K}{sup 0}K{sup +} is at the 90% confidence level. They also present improved measurements of the charge-averaged branching fraction {Beta}(B{sup +} {yields} K{sup 0}{pi}{sup +}) = (26.0 {+-} 1.3 {+-} 1.0) x 10{sup -6} and CP-violating charge asymmetry {Alpha}{sub CP} (K{sup 0}{pi}{sup +}) = -0.09 {+-} 0.05 {+-} 0.01, where the uncertainties are statistical and systematic, respectively.
Date: July 12, 2005
Creator: Aubert, B.; Barate, R.; Boutigny, D.; Couderc, F.; Karyotakis, Y.; Lees, J. P. et al.
Object Type: Article
System: The UNT Digital Library
Measurement of Branching Fractions and Mass Spectra of B to K pi pi gamma (open access)

Measurement of Branching Fractions and Mass Spectra of B to K pi pi gamma

The authors present a measurement of the partial branching fractions and mass spectra of the exclusive radiative penguin processes B {yields} K{pi}{pi}{gamma} in the range m{sub K{pi}{pi}} < 1.8 GeV/c{sup 2}. They reconstruct four final states: K{sup +}{pi}{sup -}{pi}{sup +}{gamma}, K{sup +}{pi}{sup -}{pi}{sup 0}{gamma}, K{sub S}{sup 0}{pi}{sup -}{pi}{sup +}{gamma}, and K{sub S}{sup 0}{pi}{sup +}{pi}{sup 0}{gamma}, where K{sub S}{sup 0} {yields} {pi}{sup +}{pi}{sup -}. Using 232 million e{sup +}e{sup -} {yields} B{bar B} events recorded by the BABAR experiment at the PEP-II asymmetric-energy storage ring, they measure the branching fractions {Beta}(B{sup +} {yields} K{sup +}{pi}{sup -}{pi}{sup +}{gamma}) = (2.95 {+-} 0.13(stat.) {+-} 0.20(syst)) x 10{sup -5}, {Beta}(B{sup 0} {yields} K{sup +}{pi}{sup -}{pi}{sup 0}{gamma}) = (4.07 {+-} 0.22(stat.) {+-} 0.31(syst.)) x 10{sup -5}, {Beta}(B{sup 0} {yields} K{sup 0}{pi}{sup +}{pi}{sup -}{gamma}) = (1.85 {+-} 0.21(stat.) {+-} 0.12(syst.)) x 10{sup -5}, and {Beta}(B{sup +} {yields} K{sup 0}{pi}{sup +}{pi}{sup 0}{gamma}) = (4.56 {+-} 0.42(stat.) {+-} 0.31(syst.)) x 10{sup -5}.
Date: July 12, 2005
Creator: Aubert, B.; Barate, R.; Boutigny, D.; Couderc, F.; Karyotakis, Y.; Lees, J. P. et al.
Object Type: Article
System: The UNT Digital Library
Measurement of the Branching Fraction of B0 Meson Decay to a_1^+(1260) pi- (open access)

Measurement of the Branching Fraction of B0 Meson Decay to a_1^+(1260) pi-

We present a preliminary measurement of the branching fraction of the B meson decay B{sup 0} {yields} a{sub 1}{sup +}(1260){pi}{sup -}with a{sub 1}{sup +}(1260) {yields} {pi}{sup +}{pi}{sup +}{pi}{sup -}. The data sample corresponds to 218 x 10{sup 6} B{bar B} pairs produced in e{sup +}e{sup -} annihilation through the {Upsilon}(4S) resonance. We find the branching fraction (40.2 {+-} 3.9 {+-} 3.9) x 10{sup -6}, where the first error quoted is statistical and the second is systematic. The fitted values of the a{sub 1}(1260) parameters are m{sub a{sub 1}} = 1.22 {+-} 0.02 GeV/c{sup 2} and {Lambda}{sub a{sub 1}} = 0.423 {+-} 0.050 GeV/c{sup 2}.
Date: July 12, 2005
Creator: Aubert, B.; Barate, R.; Boutigny, D.; Couderc, F.; Karyotakis, Y.; Lees, J. P. et al.
Object Type: Article
System: The UNT Digital Library
Measurement of the Time-Dependent CP-Violating Asymmetry in $B^0 \to K^{0}_s\pi^0\gamma$ Decays (open access)

Measurement of the Time-Dependent CP-Violating Asymmetry in $B^0 \to K^{0}_s\pi^0\gamma$ Decays

We present a measurement of the time-dependent CP-violating asymmetry in B{sup 0} {yields} K*{sup 0}{gamma} decays with K*{sup 0} {yields} K{sub S}{sup 0}{pi}{sup 0} based on 232 million {Upsilon}(4S) {yields} B{bar B} decays collected with the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} collider at SLAC. In a sample containing 157 {+-} 16 signal decays, we measure S{sub K*{sup 0}{gamma}} = -0.21 {+-} 0.40 {+-} 0.05 and C{sub K*{sup 0}{gamma}} = -0.40 {+-} 0.23 {+-} 0.03, where the first error is statistical and the second systematic. We also explore B{sup 0} {yields} K{sub S}{sup 0}{pi}{sup 0}{gamma} decays with 1.1 < m{sub K{sub S}{sup 0}{pi}{sup 0}} < 1.8 GeV/c{sup 2} and find 59 {+-} 13 signal events with S{sub K{sub S}{sup 0}{pi}{sup 0}{gamma}} = 0.9 {+-} 1.0 {+-} 0.2 and C{sub K{sub S}{sup 0}{pi}{sup 0}{gamma}} = -1.0 {+-} 0.5 {+-} 0.2.
Date: July 12, 2005
Creator: Aubert, B.; Barate, R.; Boutigny, D.; Couderc, F.; Karyotakis, Y.; Lees, J. P. et al.
Object Type: Article
System: The UNT Digital Library
Construction of Superconvergent Discretizations with Differential-Difference Invariants (open access)

Construction of Superconvergent Discretizations with Differential-Difference Invariants

To incorporate symmetry properties of second-order differential equations into finite difference equations, the concept of differential-difference invariants is introduced. This concept is applied to discretizing homogeneous eigenvalue problems and inhomogeneous two-point boundary value problems with various combinations of Dirichlet, Neumann, and Robin boundary conditions. It is demonstrated that discretizations constructed with differential-difference invariants yield exact results for eigenvalue spectra and superconvergent results for numerical solutions of differential equations.
Date: August 12, 2005
Creator: Axford, R. A.
Object Type: Report
System: The UNT Digital Library
Three-dimensional Simulation of Backward Raman Amplification (open access)

Three-dimensional Simulation of Backward Raman Amplification

Three-dimensional (3-D) simulations for the Backward Raman Amplification (BRA) are presented. The images illustrate the effects of pump depletion, pulse diffraction, non-homogeneous plasma density, and plasma ionization.
Date: November 12, 2005
Creator: Balakin, A. A.; Fraiman, G. M. & Fisch, N. J.
Object Type: Report
System: The UNT Digital Library
SEISMIC EVALUATION OF HYDROCARBON SATURATION IN DEEP-WATER RESERVOIRS (open access)

SEISMIC EVALUATION OF HYDROCARBON SATURATION IN DEEP-WATER RESERVOIRS

We are now entering the final stages of our ''Seismic Evaluation of Hydrocarbon Saturation in Deep-Water Reservoirs'' project (Grant/Cooperative Agreement DE-FC26-02NT15342). We have now developed several techniques to help distinguish economic hydrocarbon deposits from false ''Fizz'' gas signatures. These methods include using the proper in situ rock and fluid properties, evaluating interference effects on data, and doing better constrained inversions for saturations. We are testing these techniques now on seismic data from several locations in the Gulf of Mexico. In addition, we are examining the use of seismic attenuation as indicated by frequency shifts below potential reservoirs. During this quarter we have: Began our evaluation of our latest data set over the Neptune Field; Developed software for computing composite reflection coefficients; Designed and implemented stochastic turbidite reservoir models; Produced software & work flow to improve frequency-dependent AVO analysis; Developed improved AVO analysis for data with low signal-to-noise ratio; and Examined feasibility of detecting fizz gas using frequency attenuation. Our focus on technology transfer continues, both by generating numerous presentations for the upcoming SEG annual meeting, and by beginning our planning for our next DHI minisymposium next spring.
Date: August 12, 2005
Creator: Batzle, Michael; Han, D-h; Gibson, R. & James, Huw
Object Type: Report
System: The UNT Digital Library