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Activated type I TGFbeta receptor (Alk5) kinase confers enhancedsurvival to mammary epithelial cells and accelerates mammary tumorprogression
The transforming growth factor-betas (TGF{beta}s) are members of a large superfamily of pleiotropic cytokines that also includes the activins and the bone morphogenetic proteins (BMPs). Members of the TGF{beta} family regulate complex physiological processes such cell proliferation, differentiation, adhesion, cell-cell and cell-matrix interactions, motility, and cell death, among others (Massague, 1998). Dysregulation of TGF{beta} signaling contributes to several pathological processes including cancer, fibrosis, and auto-immune disorders (Massague et al., 2000). The TGF{beta}s elicit their biological effects by binding to type II and type I transmembrane receptor serine-threonine kinases (T{beta}RII and T{beta}RI) which, in turn, phosphorylated Smad 2 and Smad 3. Phosphorylated Smad 2/3 associate with Smad 4 and, as a heteromeric complex, translocate to the nucleus where they regulate gene transcription. The inhibitory Smad7 down regulates TGF{beta} signaling by binding to activated T{beta}RI and interfering with its ability to phosphorylate Smad 2/3 (Derynck and Zhang, 2003; Shi and Massague, 2003). Signaling is also regulated by Smad proteolysis. TGF{beta} receptor-mediated activation results in multi-ubiquitination of Smad 2 in the nucleus and subsequent degradation of Smad 2 by the proteasome (Lo and Massague, 1999). Activation of TGF{beta} receptors also induces mobilization of a Smad 7-Smurf complex from the nucleus to the cytoplasm; …
Date:
January 2, 2005
Creator:
Muraoka-Cook, Rebecca S.; Shin, Incheol; Yi, Jae Youn; Easterly,Evangeline; Barcellos-Hoff, Mary Helen; Yingling, Jonathan M. et al.
Object Type:
Article
System:
The UNT Digital Library
Altus Times (Altus, Okla.), Vol. 106, No. 229, Ed. 1 Sunday, January 2, 2005
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
January 2, 2005
Creator:
Andrews, Mike
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Alvin Sun-Advertiser (Alvin, Tex.), Vol. 115, No. 1, Ed. 1 Sunday, January 2, 2005
Weekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising.
Date:
January 2, 2005
Creator:
Schwind, Jim & Looby, Edward
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 84, No. 28, Ed. 1 Sunday, January 2, 2005
Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
January 2, 2005
Creator:
Cash, Wanda Garner
Object Type:
Newspaper
System:
The Portal to Texas History
Electrostatic LEBTs for High-Intensity Linac-Injectors
None
Date:
January 2, 2005
Creator:
Keller, R. & Kahto, S. K.
Object Type:
Article
System:
The UNT Digital Library
The Express-Star (Chickasha, Okla.), Ed. 1 Sunday, January 2, 2005
Daily newspaper from Chickasha, Oklahoma that includes local, state, and national news along with advertising.
Date:
January 2, 2005
Creator:
Bush, Kent
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Levelland and Hockley County News-Press (Levelland, Tex.), Vol. 27, No. 79, Ed. 1 Sunday, January 2, 2005
Semiweekly newspaper from Levelland, Texas that includes local, state, and national news along with advertising.
Date:
January 2, 2005
Creator:
Rigg, John
Object Type:
Newspaper
System:
The Portal to Texas History
Oral History Interview with John Land, January 2, 2005
The National Museum of the Pacific War presents an oral interview with John Ladd. Mr Ladd was sworn into the Navy July 12, 1938. After boot camp, he was assigned to the USS Maryland (BB-46) which was stationed in Long Beach and San Pedro, California at the time. The Maryland moved to Pearl Harbor in the late summer of 1941. Ladd was a gunner's mate on one of the 5-inch broadside guns. On December 7, 1941, the guns were secured and the ammunition was locked up. It took them about ten minutes to get to where they could start shooting back at the Japanese planes. Ladd tells the story of shooting down two or three American planes early in the morning of December 8th that were trying to land. He also talks about getting men out of the ships that had been sunk in the harbor including the Oklahoma that had capsized next to them. Just before Christmas 1941, the Maryland was patched up enough to sail for Bremerton, Washington for repairs. Afterwards, she went back to Pearl Harbor. Ladd was transferred off in late October 1943 and went to gunnery school in Washington, DC for three months. After school, …
Date:
January 2, 2005
Creator:
Ladd, John
Object Type:
Sound
System:
The Portal to Texas History
Oral History Interview with John Land, January 2, 2005
The National Museum of the Pacific War presents an oral interview with John Ladd. Mr Ladd was sworn into the Navy July 12, 1938. After boot camp, he was assigned to the USS Maryland (BB-46) which was stationed in Long Beach and San Pedro, California at the time. The Maryland moved to Pearl Harbor in the late summer of 1941. Ladd was a gunner's mate on one of the 5-inch broadside guns. On December 7, 1941, the guns were secured and the ammunition was locked up. It took them about ten minutes to get to where they could start shooting back at the Japanese planes. Ladd tells the story of shooting down two or three American planes early in the morning of December 8th that were trying to land. He also talks about getting men out of the ships that had been sunk in the harbor including the Oklahoma that had capsized next to them. Just before Christmas 1941, the Maryland was patched up enough to sail for Bremerton, Washington for repairs. Afterwards, she went back to Pearl Harbor. Ladd was transferred off in late October 1943 and went to gunnery school in Washington, DC for three months. After school, …
Date:
January 2, 2005
Creator:
Ladd, John
Object Type:
Text
System:
The Portal to Texas History
Paleoenvironmental analyses of an organic deposit from an erosional landscape remnant, Arctic Coastal Plain of Alaska
The dominant landscape process on the Arctic Coastal Plain of northern Alaska is the formation and drainage of thaw lakes. Lakes and drained thaw lake basins account for approximately 75% of the modern surface expression of the Barrow Peninsula. The thaw lake cycle usually obliterates lacustrine or peat sediments from previous cycles which could otherwise be used for paleoecological reconstruction of long-term landscape and vegetation changes. Several possible erosional remnants of a former topographic surface that predates the formation of the thaw lakes have been tentatively identified. These remnants are characterized by a higher elevation, a thick organic layer with very high ground ice content in the upper permafrost, and a plant community somewhat atypical of the region. Ten soil cores were collected from one site, and one core was intensively sampled for soil organic carbon content, pollen analysis, and {sup 14}C dating. The lowest level of the organic sediments represents the earliest phase of plant growth and dates to ca. 9000 cal BP. Palynological evidence indicates the presence of mesic shrub tundra (including sedge, birch, willow, and heath vegetation); and microfossil indicators point to wetter eutrophic conditions during this period. Carbon accumulation was rapid due to high net primary …
Date:
January 2, 2005
Creator:
Eisner, W R; Bockheim, J G; Hinkel, K M; Brown, T A; Nelson, F E; Peterson, K M et al.
Object Type:
Article
System:
The UNT Digital Library
The Panola Watchman (Carthage, Tex.), Vol. 132, No. 1, Ed. 1 Sunday, January 2, 2005
Semiweekly newspaper from Carthage, Texas that includes local, state, and national news along with advertising.
Date:
January 2, 2005
Creator:
unknown
Object Type:
Newspaper
System:
The Portal to Texas History
Polk County Enterprise (Livingston, Tex.), Vol. 123, No. 1, Ed. 1 Sunday, January 2, 2005
Semi-weekly newspaper from Livingston, Texas that includes local, state and national news along with advertising.
Date:
January 2, 2005
Creator:
White, Barbara
Object Type:
Newspaper
System:
The Portal to Texas History
Sapulpa Daily Herald (Sapulpa, Okla.), Vol. 90, No. 96, Ed. 1 Sunday, January 2, 2005
Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.
Date:
January 2, 2005
Creator:
Broaddus, Matthew B.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
137Cs and 210Po in Pacific Walrus and Bearded Seal from St. Lawrence Island, Alaska
The activity concentration of Cesium-137 ({sup 137}Cs) and naturally-occurring Polonium-210 ({sup 210}Po) were measured in the muscle tissue, kidney and liver of Pacific walrus (Odobenus rosmarus divergens) and bearded seal (Erignathus barbatus) collected by native hunters from the Bering Sea. The mean {sup 137}Cs concentrations in muscle, liver and kidney of Pacific walrus were 0.07, 0.09 and 0.07 Bq kg{sup -1} (N= 5, wet weight), respectively, and 0.17, 0.10, and 0.17 Bq kg{sup -1} (N=2, wet weight), respectively, in bearded seal. In general, {sup 137}Cs tissue concentrations are significantly lower than those previously reported for mammals from other regions. By comparison, {sup 210}Po activity concentrations appear to be higher than those reported elsewhere but a larger variation. The mean {sup 210}Po concentration in the muscle tissue, liver and kidney of Pacific walrus (N=5, wet weight) were 28.7, 189, and 174 Bq kg{sup -1}, respectively. This compares with {sup 210}Po concentration values (N=2, wet weight) of 27, 207, and 68 Bq kg{sup -1} measured in the muscle tissue, liver and kidney, of bearded seal, respectively. Estimated bioaccumulation factors--as defined by the radionuclide concentration ratio between the target tissue to that in sea water--were two to three orders of magnitude higher for …
Date:
February 2, 2005
Creator:
Hamilton, T F; Seagars, D J; Jokela, T & Layton, D
Object Type:
Article
System:
The UNT Digital Library
Altus Times (Altus, Okla.), Vol. 106, No. 256, Ed. 1 Wednesday, February 2, 2005
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
February 2, 2005
Creator:
Andrews, Mike
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Alvin Advertiser (Alvin, Tex.), Ed. 1 Wednesday, February 2, 2005
Weekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising.
Date:
February 2, 2005
Creator:
Schwind, Jim & Looby, Edward
Object Type:
Newspaper
System:
The Portal to Texas History
The Archer Advocate (Holliday, Tex.), Vol. 2, No. 44, Ed. 1 Wednesday, February 2, 2005
Weekly newspaper from Holliday, Texas that includes local, state, and national news along with advertising.
Date:
February 2, 2005
Creator:
Thomas, John
Object Type:
Newspaper
System:
The Portal to Texas History
Broadband Internet Access and the Digital Divide: Federal Assistance Programs
This report provides an overview of the "digital divide", which is a term used to describe a perceived gap between those Americans who use or have access to telecommunications and information technologies and those who do not.
Date:
February 2, 2005
Creator:
Kruger, Lennard G.
Object Type:
Report
System:
The UNT Digital Library
CALFED Bay-Delta Program: Overview of Institutional and Water Use Issues
The California Bay-Delta Program (CALFED) was initiated in 1995 to resolve water resources conflicts in the Sacramento/San Joaquin Rivers Delta and San Francisco Bay (Bay-Delta) in California. The program planning effort focused on developing a plan to address three main problem areas in the Bay-Delta: ecosystem health, water quality, and water supply reliability. CALFED was authorized to receive federal funding from FY1998 to FY2000, and is now being considered for reauthorization.
Date:
February 2, 2005
Creator:
Sheikh, Pervaze A. & Cody, Betsy A.
Object Type:
Report
System:
The UNT Digital Library
Cherokeean Herald (Rusk, Tex.), Vol. 155, No. 50, Ed. 1 Wednesday, February 2, 2005
Weekly newspaper from Rusk, Texas that includes local, state and national news along with extensive advertising.
Date:
February 2, 2005
Creator:
Whitehead, Marie
Object Type:
Newspaper
System:
The Portal to Texas History
The Colony Courier-Leader (The Colony, Tex.), Vol. 23, No. 52, Ed. 1 Wednesday, February 2, 2005
Weekly newspaper from The Colony, Texas that includes local, state, and national news along with advertising.
Date:
February 2, 2005
Creator:
Sorter, Dave
Object Type:
Newspaper
System:
The Portal to Texas History
A Computational Model with Experimental Validation for DNA Flow in Microchannels
The authors compare a computational model to experimental data for DNA-laden flow in microchannels. The purpose of this work in progress is to validate a new numerical algorithm for viscoelastic flow using the Oldroyd-B model. The numerical approach is a stable and convergent polymeric stress-splitting scheme for viscoelasticity. They treat the hyperbolic part of the equations of motion with an embedded boundary method for solving hyperbolic conservation laws in irregular domains. They enforce incompressibility and evolve velocity and pressure with a projection method. The experiments are performed using epifluorescent microscopy and digital particle image velocimetry to measure velocity fields and track the conformation of biological macromolecules. They present results comparing velocity fields and the observations of computed fluid stress on molecular conformation in various microchannels.
Date:
February 2, 2005
Creator:
Nonaka, A; Gulati, S; Trebotich, D; Miller, G H; Muller, S J & Liepmann, D
Object Type:
Article
System:
The UNT Digital Library
Controversies over Redefining “Fill Material” Under the Clean Water Act
This report discusses the revived rule, focusing on how it would change which material and types of activities are regulated under Section 404 and the significance of these issues, especially for the mining industry.
Date:
February 2, 2005
Creator:
Copeland, Claudia
Object Type:
Report
System:
The UNT Digital Library
The Cuero Record (Cuero, Tex.), Vol. 111, No. 5, Ed. 1 Wednesday, February 2, 2005
Weekly newspaper from Cuero, Texas that includes local, state, and national news along with advertising.
Date:
February 2, 2005
Creator:
Rea, Glenn
Object Type:
Newspaper
System:
The Portal to Texas History