Semi-weekly newspaper from Bastrop, Texas that includes local, state, and national news along with extensive advertising.

Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story. B-roll video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.

Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.

We are preparing progestins and androgens, labeled with the single photon emitters technetium-99m and rhenium-186 and the positron-emitting radionuclide fluorine-18. In both cases, ligands selected have very high affinity for the respective receptor, low affinity for blood and non-specific binders and to be reasonably resistant to metabolism: The progestins will be derivatives of the potent progestins ORG2058, norgestrel, RU486, and an unusual retroprogestin and the androgens will be derivatives of the high affinity analogs of natural and synthetic androgens. Radiometal labeling will involve carefully designed steroid conjugates with N[sub 2]S[sub 2] or related chelates, or novel metal linkages, and metal complexes that themselves mimic a steroid. Fluorine substitution will be made at positions where bulk and polarity are tolerated and metabolic defluorination is minimal. In vitro competitive binding studies will be performed on the unlabeled analogs to determine their binding characteristics towards a series of steroid receptors and blood binding proteins, and Log P values will be estimated from BPLC. Tissue distribution studies with the radiolabeled progestins will be done in estrogen-primed rats using the uterus as a target, and with the radioandrogens in estrogen-treated rats using the prostate as a target. Ultimately, in collaborative studies, these radiopharmaceuticals are to …

Newsletter of the Texas Bureau of Disease Control and Epidemiology discussing the news, activities, and events of the organization and other information related to health in Texas.

We are preparing progestins and androgens, labeled with the single photon emitters technetium-99m and rhenium-186 and the positron-emitting radionuclide fluorine-18. In both cases, ligands selected have very high affinity for the respective receptor, low affinity for blood and non-specific binders and to be reasonably resistant to metabolism: The progestins will be derivatives of the potent progestins ORG2058, norgestrel, RU486, and an unusual retroprogestin and the androgens will be derivatives of the high affinity analogs of natural and synthetic androgens. Radiometal labeling will involve carefully designed steroid conjugates with N{sub 2}S{sub 2} or related chelates, or novel metal linkages, and metal complexes that themselves mimic a steroid. Fluorine substitution will be made at positions where bulk and polarity are tolerated and metabolic defluorination is minimal. In vitro competitive binding studies will be performed on the unlabeled analogs to determine their binding characteristics towards a series of steroid receptors and blood binding proteins, and Log P values will be estimated from BPLC. Tissue distribution studies with the radiolabeled progestins will be done in estrogen-primed rats using the uterus as a target, and with the radioandrogens in estrogen-treated rats using the prostate as a target. Ultimately, in collaborative studies, these radiopharmaceuticals are to …

Letter from Mary Regalbuto Jones to the Women Airforce Service Pilots discussing the details of the WASP 50th Anniversary Conference such as the event venue, date and dress attire.

Daily newspaper from Perry, Oklahoma that includes local, state, and national news along with advertising.

Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.

Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.

B-roll video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.

B-roll video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.

B-roll video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.

Semiweekly newspaper from Pawhuska, Oklahoma that includes local, state, and national news along with advertising.