Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle (open access)

Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle

This article is an overview the interplay between HIV-1 viral and cellular proteins for restrictions/competitions for proliferation of the virus in the infected cell, which could open a new avenue for the development of therapeutics against HIV-1 via targeting a specific step of the proteasome degradation pathway during the HIV-1 life cycle.
Date: June 19, 2019
Creator: Rojas, Vivian K. & Park, In-Woo
System: The UNT Digital Library
The Potential Role of Nanotechnology in Therapeutic Approaches for Triple Negative Breast Cancer (open access)

The Potential Role of Nanotechnology in Therapeutic Approaches for Triple Negative Breast Cancer

This review is focused on opportunities for developing new approaches for filling the current void in an effective treatment for Triple Negative Breast Cancer, TNBC, patients. Triple Negative Breast Cancer, TNBC, a highly aggressive and metastatic type of breast cancer, is characterized by loss of expression of the estrogen receptor (ER), progesterone receptor (PR), and a lack of overexpression of the human epidermal growth factor receptor 2 (HER2).
Date: June 18, 2013
Creator: Johnson, Rebecca; Sabnis, Nirupama; McConathy, Walter J. & Lacko, Andras G.
System: The UNT Digital Library
Thymus Functionality Needs More Than a Few TECs (open access)

Thymus Functionality Needs More Than a Few TECs

Article is a review exploring the contributions of the many stromal cell types participating in the formation, expansion, and contraction of the thymus under normal and pathophysiological processes. Such information will better inform approaches for restoring thymus functionality, including thymus organoid technologies, beneficial when an individuals’ own tissue is congenitally, clinically, or accidentally rendered non-functional.
Date: June 10, 2022
Creator: Bhalla, Pratibha; Su, Dong-Ming & van Oers, Nicolai S. C.
System: The UNT Digital Library
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3 (open access)

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

A series of editorials highlighting in brief reports recently published articles describing crucial findings in the field of medical chemistry.
Date: June 30, 2018
Creator: Mangoni, Arduino A; Tuccinardi, Tiziano; Collina, Simona; Vanden Eynde, Jean Jacques; Muñoz-Torrero, Diego; Karaman, Rafik et al.
System: The UNT Digital Library
Safety of Continuous Infusion Ketorolac in Postoperative Coronary Artery Bypass Graft Surgery Patients (open access)

Safety of Continuous Infusion Ketorolac in Postoperative Coronary Artery Bypass Graft Surgery Patients

This article evaluates the safety of continuous infusion ketorolac which is sometimes utilized for analgesia in postoperative coronary artery bypass graft (CABG) patients. This retrospective cohort study evaluated the primary outcome of mortality and secondary outcomes of incidence of bleeding and myocardial infarction (MI). No association was found between continuous infusion ketorolac and increased risk of mortality, MI, or bleeding events in postoperative CABG patients.
Date: June 28, 2016
Creator: Howard, Meredith L.; Warhurst, Robert D. & Sheehan, Courtney
System: The UNT Digital Library
Regulation of Autophagy by Kinases (open access)

Regulation of Autophagy by Kinases

This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated kinase, Akt, mitogen-activated protein kinase (ERK, p38 and JNK) and protein kinase C that are often deregulated in cancer and are important therapeutic targets.
Date: June 9, 2011
Creator: Sridharan, Savitha; Jain, Kirti & Basu, Alakananda
System: The UNT Digital Library
Pulmonary Carcinoid Surface Receptor Modulation Using Histone Deacetylase Inhibitors (open access)

Pulmonary Carcinoid Surface Receptor Modulation Using Histone Deacetylase Inhibitors

Study describes the use of a non-cytotoxic dose of histone deacetylase (HDAC) inhibitors to induce pulmonary carcinoid somatostatin receptor subtype 2 (SSTR2) expression to diagnose pulmonary carcinoids.
Date: June 3, 2019
Creator: Guenter, Rachael E.; Aweda, Tolulope; Matos, Danilea M. Carmona; Whitt, Jason; Chang, Alexander W.; Cheng, Eric Y. et al.
System: The UNT Digital Library
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5 (open access)

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

The article is part of a series of Editorials published biannually that highlights a number of recently published articles that describe crucial findings.
Date: June 30, 2019
Creator: Mangoni, Arduino A; Vanden Eynde, Jean Jacques; Jampilek, Josef; Hadjipavlou-Litina, Dimitra; Liu, Hong; Reynisson, Jóhannes et al.
System: The UNT Digital Library