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A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma
This study further explores a prior screening program carried out using MTT assay that identified a series of novel benzimidazole derivatives, among which Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) showed highest anticancer efficacy compared to that of chemotherapeutic agent, cisplatin. In this article, the authors find that MBIC inhibited cell viability in different hepatocellular carcinoma (HCC) cell lines without exerting significant cytotoxic effects on normal liver cells. The results of this study demonstrate that MBIC may inhibit cell proliferation via ROS-mediated activation of the JNK signaling cascade in HCC cells.
Date:
January 12, 2017
Creator:
Dai, Xiaoyun; Wang, Ling Zhi; Deivasigamni, Amudha; Looi, Chung Yeng; Karthikeyan, Chandrabose; Trivedi, Piyush et al.
System:
The UNT Digital Library
Nature-Guided Synthesis of Advanced Bio-Lubricants
Article describes study which finds that Orychophragmus violaceus (Ov) seed oil has superior lubrication properties, based on the unusual structural features of the major lipid species—triacylglycerol (TAG) estolides.
Date:
August 12, 2019
Creator:
Romsdahl, Trevor; Shirani, Asghar; Minto, Robert E.; Zhang, Chunyu; Cahoon, Edgar B.; Chapman, Kent Dean et al.
System:
The UNT Digital Library
Evaluation of the RDP Classifier Accuracy Using 16S rRNA Gene Variable Regions
This article uses full-length 16S rRNA gene alignments from the SILVA database to simulate the PCR products of the combined variable regions.
Date:
March 12, 2012
Creator:
Vilo, Claudia A. & Dong, Qunfeng
System:
The UNT Digital Library
The Unique Fold and Lability of the [2fe‑2s] Clusters of Neet Proteins Mediate Their Key Functions in Health and Disease
This article discusses the NEET fold and its structural elements.
Date:
February 12, 2018
Creator:
Karmi, Ola; Marjault, Henri-Baptiste; Pesce, Luca; Carloni, Paolo; Onuchic, José N.; Jennings, Patricia A. et al.
System:
The UNT Digital Library
Art therapy and music reminiscence activity in the prevention of cognitive decline: study protocol for a randomized controlled trial
This article explores the feasibility of using art therapy and music reminiscence activity to improve the cognition of community living elderly with mild cognitive impairment.
Date:
July 12, 2017
Creator:
Mahendran, Rathi; Rawtaer, Iris; Fam, Johnson; Wong, Jonathan; Kumar, Alan Prem; Gandhi, Mihir et al.
System:
The UNT Digital Library
Bioinformatics tools for cancer metabolomics
This review focuses on the use of different bioinformatics tools in cancer metabolomics studies.
Date:
January 12, 2011
Creator:
Blekherman, Grigoriy; Laubenbacher, Reinhard; Cortes, Diego F.; Mendes, Pedro; Torti, Frank M.; Akman, Steven et al.
System:
The UNT Digital Library
Quantitative assessment of sad emotion
Article on a quantitative assessment of sad emotion.
Date:
February 12, 2015
Creator:
Tam, Nicoladie D.
System:
The UNT Digital Library
Distinct cinnamoyl CoA reductases involved in parallel routes to lignin in Medicago truncatula
Article on distinct cinnamoyl CoA reductases involved in parallel routes to lignin in Medicago truncatula.
Date:
October 12, 2010
Creator:
Zhou, Rui; Jackson, Lisa A.; Shadle, Gail L.; Nakashima, Jin; Temple, Stephen; Chen, Fang et al.
System:
The UNT Digital Library
Botulinum Toxin Suppression of CNS Network Activity In Vitro
Article on botulinum toxin suppression of CNS network activity in vitro.
Date:
February 12, 2014
Creator:
Pancrazio, Joseph J.; Gopal, Kamakshi V.; Keefer, Edward W. & Gross, Guenter W.
System:
The UNT Digital Library
Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development
Article discussing label-free shotgun proteomics and metabolite analysis revealing a significant metabolic shift during citrus fruit development.
Date:
August 12, 2011
Creator:
Katz, Ehud; Boo, Kyung Hwan; Kim, Ho Youn; Eigenheer, Richard A.; Phinney, Brett S.; Shulaev, Vladimir et al.
System:
The UNT Digital Library
Ursolic Acid Inhibits the Initiation, Progression of Prostate Cancer and Prolongs the Survival of TRAMP Mice by Modulating Pro-Inflammatory Pathways
Article on ursolic acid inhibiting the initiation, progression of prostate cancer and prolonging the survival of TRAMP mice by modulating pro-inflammatory pathways.
Date:
March 12, 2012
Creator:
Shanmugam, Muthu K.; Ong, Tina H.; Kumar, Alan Prem; Chang, Kai Lun; Ho, Paul C.; Wong, Peter T. H. et al.
System:
The UNT Digital Library
N-Palmitoylethanolamine depot injection increased its tissue levels and those of other acylethanolamide lipids
Article discussing how the N-palmitoylethanolamine depot injection increased its tissue levels and those of other acylethanolamide lipids.
Date:
August 12, 2013
Creator:
Grillo, Stephanie L.; Keereetaweep, Jantana; Grillo, Michael A.; Chapman, Kent D. & Koulen, Peter
System:
The UNT Digital Library