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11 Matching Results
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The human DNA-activated protein kinase, DNA-PK: Substrate specificity
Although much has been learned about the structure and function of p53 and the probable sequence of subsequent events that lead to cell cycle arrest, little is known about how DNA damage is detected and the nature of the signal that is generated by DNA damage. Circumstantial evidence suggests that protein kinases may be involved. In vitro, human DNA-PK phosphorylates a variety of nuclear DNA-binding, regulatory proteins including the tumor suppressor protein p53, the single-stranded DNA binding protein RPA, the heat shock protein hsp90, the large tumor antigen (TAg) of simian virus 40, a variety of transcription factors including Fos, Jun, serum response factor (SRF), Myc, Sp1, Oct-1, TFIID, E2F, the estrogen receptor, and the large subunit of RNA polymerase II (reviewed in Anderson, 1993; Jackson et al., 1993). However, for most of these proteins, the sites that are phosphorylated by DNA-PK are not known. To determine if the sites that were phosphorylated in vitro also were phosphorylated in vivo and if DNA-PK recognized a preferred protein sequence, the authors identified the sites phosphorylated by DNA-PK in several substrates by direct protein sequence analysis. Each phosphorylated serine or threonine is followed immediately by glutamine in the polypeptide chain; at no …
Date:
November 5, 1994
Creator:
Anderson, C.W.; Connelly, M.A.; Zhang, H.; Sipley, J.A.; Lees-Miller, S.P.; Lintott, L.G. et al.
Object Type:
Report
System:
The UNT Digital Library
Mannford Star (Mannford, Okla.), Vol. 1, No. 9, Ed. 1 Saturday, November 5, 1994
Weekly newspaper from Mannford, Oklahoma that includes local, state, and national news along with advertising.
Date:
November 5, 1994
Creator:
Fleming, Colleen A.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Oklahoma Daily (Norman, Okla.), Vol. 79, No. 60, Ed. 1 Saturday, November 5, 1994
Student newspaper of the University of Oklahoma in Norman, Oklahoma that includes national, local, and campus news along with advertising.
Date:
November 5, 1994
Creator:
Jungman, Nicholas
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
[News Clip: Red Oak]
Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.
Date:
November 5, 1994, 6:00 p.m.
Creator:
KXAS-TV (Television station : Fort Worth, Tex.)
Object Type:
Video
System:
The UNT Digital Library
[News Clip: Smith boys]
Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.
Date:
November 5, 1994, 6:00 p.m.
Creator:
KXAS-TV (Television station : Fort Worth, Tex.)
Object Type:
Video
System:
The UNT Digital Library
[News Clip: Storms]
Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.
Date:
November 5, 1994, 10:00 p.m.
Creator:
KXAS-TV (Television station : Fort Worth, Tex.)
Object Type:
Video
System:
The UNT Digital Library
[News Clip: TX Round up]
Video footage from the KXAS-TV television station in Fort Worth, Texas, covering a news story.
Date:
November 5, 1994, 10:00 p.m.
Creator:
KXAS-TV (Television station : Fort Worth, Tex.)
Object Type:
Video
System:
The UNT Digital Library
The National Information Infrastructure: The Federal Role
None
Date:
November 5, 1994
Creator:
McLoughlin, Glenn J.
Object Type:
Report
System:
The UNT Digital Library
Perry Daily Journal (Perry, Okla.), Vol. 101, No. 229, Ed. 1 Saturday, November 5, 1994
Daily newspaper from Perry, Oklahoma that includes local, state, and national news along with advertising.
Date:
November 5, 1994
Creator:
Watson, Milo W.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Chickasha Star (Chickasha, Okla.), Vol. 93, No. 41, Ed. 1 Saturday, November 5, 1994
Semiweekly newspaper from Chickasha, Oklahoma that includes local, state, and national news along with advertising.
Date:
November 5, 1994
Creator:
unknown
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Pawhuska Journal-Capital (Pawhuska, Okla.), Vol. 84, No. 89, Ed. 1 Saturday, November 5, 1994
Semiweekly newspaper from Pawhuska, Oklahoma that includes local, state, and national news along with advertising.
Date:
November 5, 1994
Creator:
unknown
Object Type:
Newspaper
System:
The Gateway to Oklahoma History