Current regulations require RPV steels to maintain conservative margins of fracture toughness so that postulated flaws do not threaten the integrity of the RPV during either normal operation and maintenance cycles or under accident transients, like pressurized thermal shock. Neutron irradiation degrades fracture toughness, in some cases severely. Thermal aging, while not generally considered a significant issue for a 40-y operating life, must be an additional consideration for operation to 60 or 80 years. Regulations, codified in the ASME Boiler and Pressure Vessel Code, Regulatory Guide 1.99 Rev 2, etc., recognize that embrittlement has a potential for reducing toughness below acceptable levels. The last few decades have seen remarkable progress in developing a mechanistic understanding of irradiation embrittlement. This understanding has been exploited in formulating robust, physically-based and statistically-calibrated models of CVN-indexed transition-temperature shifts (TTS). These semi-empirical models account for key embrittlement variables and variable interactions, including the effects of copper (Cu), nickel (Ni), phosphorous (P), fluence ({phi}t), flux ({phi}), and irradiation temperature (T{sub i}). However, these models and our present understanding of radiation damage are not fully quantitative, and do not treat all potentially significant variables and issues. Over the past three decades, developments in fracture mechanics have led …