This background paper, which describes the state-of the- art of identifying substances that can harm the immune system, represents one response to the committee’s request. Chapter 2 provides basic information about the principal components of the immune system and the general consequences that stem from perturbations to it. Chapter 3 describes methods for evaluating chemical immunotoxicity and reports on some known or suspected immunotoxicants. Chapter 4 summarizes Federal research and regulatory activities related to immunotoxicity.

This report describes, documents, and analyzes available data about two key waste management problems at the Department of Energy Weapons Complex—those of high-level radioactive waste and transuranic waste. The paper is organized in two chapters—” Chapter 1: Managing High Level Waste’ and ‘Chapter 2: Managing Transuranic Waste. ” Each chapter contains a summary overview followed by a discussion and analysis of important areas in the waste management problem that the DOE faces at present and in its future operations.

This OTA Background Paper presents the results of a survey of 1,500 U.S. companies, the 50 largest utilities, and the largest unions. The survey was designed to obtain information about the types of medical monitoring and screening done in the United States and the extent of their use. OTA finds that virtually all large U.S. employers use some of these tests.

This background paper discusses the legacy of 40 years of U.S. university/AID collaboration, and examines new opportunities for U.S. university participation in development assistance.

This paper presents results from a 1991 OTA survey of 431 genetic counselors and nurse geneticists. It was conducted to better understand the environment in which the average genetic counselor or nurse in genetics works, to describe the infrastructure and tools available to these professionals, to assess the state of practice in the provision of cystic fibrosis (CF) carrier screening, and to evaluate their attitudes regarding CF carrier screening.

This background paper describes results from a 1991 OTA survey of U.S. health insurers’ attitudes toward genetic tests and genetic information— both how they currently view information from various sources (e.g., genetic tests, other medical tests, or family histories) in underwriting decisions and how they might reimburse consumers for genetic tests. It also reports data on the role health insurers expect genetic tests and genetic information will play in their business practices over the coming decade.

This Background Paper examines whether the agencies responsible for administering Federal environmental and health and safety laws have taken this concern for respiratory health to heart. This paper provides a partial response to the committees’ request for an assessment of noncancer health risks in the environment and follows OTA’s previous work on carcinogenic, neurotoxic, and immunotoxic substances.

This background paper first describes the structure and management of the French defense-industrial base and then reviews a variety of strategies the French Government and industry are pursuing to rationalize the base, while preserving key technological assets and strengthening the competitive position of French defense contractors in world markets.

This background paper examines wastes generated by industrial activities that play a dominant role in our national economy-oil and gas production, mining and mineral processing, coal combustion, and manufacturing. In previous reports on municipal solid waste and medical waste, OTA examined other solid wastes not classified as hazardous.

This background paper briefly describes the Army’s chemical weapons destruction program, discusses the factors that could affect a decision to develop alternatives, discusses the alternatives, and illustrates the difficulty of gaining public acceptance of complex technical systems.

This background paper reviews and evaluates the available literature linking health insurance coverage with the utilization and process of health care services and with individual health outcomes.

This background paper describes what is known about the natural progression of the menopause and its effect on women’s health, hormone treatment and prescribing practices, alternative approaches, and research needs.

This background paper describes what appears to be an enlarging potential for conflict between the two, as reflected in disputes about the trade impacts of environmental laws and about the environmental impacts arising from efforts to liberalize trade and investment. The paper explores some trade and environment questions, especially from the context of the General Agreement on Tariffs and Trade, which provides a framework of rules governing most of the world’s trade.

Adult education needs are difficult to define and difficult to meet; what constitutes adequate literacy changes continually as the demands facing individuals grow more complex. This report is an attempt to identify those capabilities, along with limitations, and outline how new information technologies can be marshaled to meet the goal of a fully literate citizenry.

This background paper analyzes technologies for tomorrow’s information superhighways. Advanced networks will first be used to support scientists in their work, linking researchers to supercomputers, databases, and scientific instruments. The paper also describes six test networks that are being funded as part of the High Performance Computing and Communications Program.

This report examines the U.S. preparations process for WARC-92, highlighting efforts to integrate the needs and concerns of various interest groups. It also reviews the forces and trends affecting the United States as it approaches WARC-92, and is intended to inform future congressional oversight of the domestic and international radio communication policy process.

This background paper was prompted by a workshop held at OTA in early March 1995, at which a small group, representing a broad cross-section of lower-tier firms, discussed their views of the space transportation industry.

This paper assesses the medical benefits and costs of both screening and hormone replacement therapy. It is divided into two volumes. This volume presents the results of a model that estimates the cost per year of life gained from osteoporosis screening and hormone replacement therapy in postmenopausal women.

This paper assesses the medical benefits and costs of both screening and hormone replacement therapy. It is divided into two volumes. This volume provides the basis for the assumptions about the costs and effects of screening and hormonal replacement therapy used in the cost-effectiveness model.

This paper examines what is known about administrative costs in the health care systems of the United States and several other countries. In addition to exploring the types of activities that constitute health care administration, it reviews studies that measure and compare these activities in different countries, and it explores the potential usefulness of such comparisons.

This paper reviews how the United States compares with other developed countries on available health status measures, evaluates the validity of the data used to make such comparisons, and describes how international comparisons might be interpreted in the context of health care reform.

The report reviews data concerning the contribution of genetic factors to several severe mental disorders; described methodologies used in the studies, and broached several policy issues relevant to this area of research.

In June 1995, OTA convened a workshop that brought together some of the world’s leading practitioners, academic experts, experienced diplomats, and leading technologists in order to study and discuss this issue. This report contains a summary of the results of the workshop, along with the original papers presented.

This report examines the question of how telecommunication related aid policies might be designed to support both United States trade and foreign aid goals.