This research was a controlled group outcome study to determine the effectiveness of a multisystem therapeutic intervention for hyperarousal to stress. It was assumed that the hyperarousal syndrome is a generalized and undifferentiated response which involves multisystems of the organism, including physiological-autonomic aspects, cognitive appraisals and imagery, affective components, and an array of overt and covert behavioral responses. If the hyperarousal syndrome persists over a period of time, a psychophysiological disorder may occur in the response system that has been repeatedly stimulated. It was postulated that learning to maintain the arousal state within a normal range of functioning may prevent the occurrence of psychophysiological diseases. Verbal reports of the experimental group indicate a beginning ability to transfer the learned low-arousal response to real-life situations. The results of this study suggest that learning a low-arousal adaptation to stress may have important implications for prevention or attenuation of psychophysiological and psychiatric disorders.