The problem with which this investigation was concerned was that of determining the relationship between the variables of acculturation, imagery, self-concept, anxiety, stress, and seriousness of disease in Mexican-Americans. The purposes of this study were 1) to determine the statistical predictive efficiency of stress and its relation to disease, 2) to determine if a combination of anxiety, acculturation, self-concept, imagery, along with stress, would increase the statistical predictive efficiency concerning seriousness of disease, and 3) to provide information that may help to develope a theoretical base concerning the above variables and disease in Mexican-Americans.