Relativistic electrons can be accelerated by an ultraintense laser pulse in the "supra-bubble" regime, that is, in the blow-out regime ahead of the plasma bubble (as opposed to the conventional method, when particles remain inside the bubble). The acceleration is caused by the ponderomotive force of the pulse, via the so-called snow-plow mechanism. The maximum energy gain, Δγ ~ γg a, is attained when the particle Lorentz factor γ is initially about γg/a, where γg is the pulse group speed Lorentz factor, and a is the laser parameter, proportional to the laser field amplitude. The scheme operates at a ≤ γg, yielding Δγ of up to that via wakefield acceleration for the same plasma and laser parameters, Δγ ~ γ2g. The interaction length is shorter than that for the wake field mechanism but grows with the particle energy, hindering acceleration in multiple stages.

Exposure to ionizing radiation and other environmental agents can affect the genomic integrity of germ cells and induce adverse health effects in the progeny. Efficient DNA repair during gametogenesis and the early embryonic cycles after fertilization is critical for preventing transmission of DNA damage to the progeny and relies on maternal factors stored in the egg before fertilization. The ability of the maternal repair machinery to repair DNA damage in both parental genomes in the fertilizing egg is especially crucial for the fertilizing male genome that has not experienced a DNA repair-competent cellular environment for several weeks prior to fertilization. During the DNA repair-deficient period of spermatogenesis, DNA lesions may accumulate in sperm and be carried into the egg where, if not properly repaired, could result in the formation of heritable chromosomal aberrations or mutations and associated birth defects. Studies with female mice deficient in specific DNA repair genes have shown that: (i) cell cycle checkpoints are activated in the fertilized egg by DNA damage carried by the sperm; and (ii) the maternal genotype plays a major role in determining the efficiency of repairing genomic lesions in the fertilizing sperm and directly affect the risk for abnormal reproductive outcomes. There …