A letter report issued by the Government Accountability Office with an abstract that begins "In spring 2007, the Department of Health and Human Services (HHS), the Department of Homeland Security (DHS), and state and local health officials worked together to interdict two individuals with drug-resistant infectious tuberculosis (TB) from crossing U.S. borders and direct them to treatment. Concerns arose that HHS's and DHS's responses to the incidents were delayed and ineffective. GAO was asked to examine (1) the factors that affected HHS's and DHS's responses to the incidents, (2) the extent to which HHS and DHS made changes to response procedures as a result of the incidents, and (3) HHS's and DHS's efforts to assess the effectiveness of changes made as a result of the incidents. GAO reviewed agency documents and interviewed officials about the procedures in place at the time of the incidents and changes made since."

We have started upgrading the control room programs for the injector at the Advanced Light Source (ALS). We chose to program in C* exclusively on the .NET Framework to create EPICS client programs on Windows Vista PCs. This paper reports the status of this upgrade project.

We report the demonstration of a reflection microscope that operates at 13.2-nm wavelength with a spatial resolution of 55 {+-} 3 nm. The microscope uses illumination from a table-top EUV laser to acquire aerial images of photolithography masks with a 20 second exposure time. The modulation transfer function of the optical system was characterized.

Chromosomal mosaicism in human preimplantation embryos is a common cause ofspontaneous abortions, however, our knowledge of its etiology is limited. We used multicolor fluorescence in situ hybridization (FISH) painting to investigate whether paternally-transmitted chromosomal aberrations result in mosaicism in mouse 2-cell embryos. Paternal exposure to acrylamide, an important industrial chemical also found in tobacco smoke and generated during the cooking process of starchy foods, produced significant increases in chromosomally defective 2-cell embryos, however, the effects were transient primarily affecting the postmeiotic stages of spermatogenesis. Comparisons with our previous study of zygotes demonstrated similar frequencies of chromosomally abnormal zygotes and 2-cell embryos suggesting that there was no apparent selection against numerical or structural chromosomal aberrations. However, the majority of affected 2-cell embryos were mosaics showing different chromosomal abnormalities in the two blastomeric metaphases. Analyses of chromosomal aberrations in zygotes and 2-cell embryos showed a tendency for loss of acentric fragments during the first mitotic division ofembryogenesis, while both dicentrics and translocations apparently underwent propersegregation. These results suggest that embryonic development can proceed up to the end of the second cell cycle of development in the presence of abnormal paternal chromosomes and that even dicentrics can persist through cell division. The high …

We report the scaling behavior of Barkhausen avalanches for every small field step along the hysteresis loop in CoCrPt alloy film having perpendicular magnetic anisotropy. Individual Barkhausen avalanche is directly observed utilizing a high-resolution soft X-ray microscopy that provides real space images with a spatial resolution of 15 nm. Barkhausen avalanches are found to exhibit power-law scaling behavior at all field steps along the hysteresis loop, despite their different patterns for each field step. Surprisingly, the scaling exponent of the power-law distribution of Barkhausen avalanches is abruptly altered from 1 {+-} 0.04 to 1.47 {+-} 0.03 as the field step is close to the coercive field. The contribution of coupling among adjacent domains to Barkhausen avalanche process affects the sudden change of the scaling behavior observed at the coercivity-field region on the hysteresis loop of CoCrPt alloy film.

In this project we developed further a twin approach to the study of regional-scale climate variability and change. The two approaches involved probabilistic network (PN) models (sometimes called dynamic Bayesian networks) and intermediate-complexity coupled ocean-atmosphere models (ICMs). We thus made progress in identifying the predictable modes of climate variability and investigating their impacts on the regional scale. In previous work sponsored by DOE’s Climate Change Prediction Program (CCPP), we had developed a family of PNs (similar to Hidden Markov Models) to simulate historical records of daily rainfall, and used them to downscale seasonal predictions of general circulation models (GCMs). Using an idealized atmospheric model, we had established a novel mechanism through which ocean-induced sea-surface temperature (SST) anomalies might influence large-scale atmospheric circulation patterns on interannual and longer time scales; similar patterns were found in a hybrid coupled ocean–atmosphere–sea-ice model. In this continuation project, we built on these ICM results and PN model development to address prediction of rainfall and temperature statistics at the local scale, associated with global climate variability and change, and to investigate the impact of the latter on coupled ocean–atmosphere modes. Our main project results consist of extensive further development of the hidden Markov models for rainfall …

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That tumor cells for all practical purposes are unstable and plastic could be expected. However, the astonishing ability of the nuclei from cells of normal adult tissues to be reprogrammed - given the right embryonic context - found its final truth even for mammals in the experiments that allowed engineering Dolly (1). The landmark experiments showed that nuclei originating from cells of frozen mammary tissues were capable of being reprogrammed by the embryonic cytoplasm and its microenvironment to produce a normal sheep. The rest is history. However, whether microenvironments other than those of the embryos can also reprogram adult cells of different tissue origins still containing their cytoplasm is of obvious interest. In this issue of PNAS, the laboratory of Gilbert Smith (2) reports on how the mammary gland microenvironment can reprogram both embryonic and adult stem neuronal cells. The work is a follow-up to their previous report on testis stem cells that were reprogrammed by the mammary microenvironment (3). They demonstrated that cells isolated from the seminiferous tubules of the mature testis, mixed with normal mammary epithelial cells, contributed a sizable number of epithelial progeny to normal mammary outgrowths in transplanted mammary fat pads. However, in those experiments they …

This report documents the results of a project undertaken to develop an ultra-high-accuracy measurement capability, which is necessary to address a rising trend toward miniaturized mechanical products exhibiting dramatically reduced product tolerances. A significant improvement in measurement capability is therefore required to insure that a 4:1 ratio can be maintained between product tolerances and measurement uncertainty.

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This report is on The Americans with Disabilities Act: Supreme Court Decisions.

This report contains an overview of the development and demand on advanced wireless technology services.

This report provides information about the Funding and Re authorization of Community Services Block Grants (CSBG). CSBG administered by the department of health and human services(HSS), provides federal funds to states ,territories,tribes for distribution to local agencies for activities to reduce poverty.

Belarusian President Aleksandr Lukashenko snuffed out Belarus's modest progress toward democracy and a free market economy in the early 1990s and created an authoritarian, Soviet-style regime. Belarus held parliamentary elections in September 2008. Supporters of the government won all of the seats in the vote, which was criticized by the U.S., EU, and OSCE as falling short of international standards. Belarus's economy is the most unreformed in Europe, according to most observers. This report contains an overview of Belarus, the political and economic situation, relations of the country with Russia, relations with Nato, the European Union, and Belarus, and U.S. policy and Congressional action.

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Unemployment compensation (UC) benefits have been fully subject to the federal income tax since the passage of the Tax Reform Act of 1986 (P.L. 99-514). Individuals who receive UC benefits during a year may elect to have the federal (and in some cases state) income tax withheld from their benefits. H.R. 6844 would provide a two-year suspension of the taxation of UC benefits. This report provides an overview of the taxation of UC benefits and legislation related to taxing UC benefits.

This report frames potential policy questions concerning the Service's mission and organization through an examination of the USSS history and its statutory authorities, mission, and present activities within DHS.

This report discusses the administrations' proposal to use reverse Dutch auctions to purchase troubled assets -- primarily mortgage-related securities from financial institutions.

This report discusses the conversion of employees from appointed (noncareer) positions to career positions in the executive branch. This practice, commonly referred to as "burrowing in," is permissible when laws and regulations governing career appointments are followed.

This report discusses the enactment of greenhouse gas (GHG) emission reduction program, such as a cap-and-trade system. An estimate of the quantity and type of offset projects that might be available would provide for a more informed debate over the design elements of a cap-and-trade program.

This report outlines the implementation process for the 1997 fine particulate matter (PM2.5) National Ambient Air Quality Standards (NAAQS) and describes issues raised as U.S. Environmental Protection Agency (EPA) and states develop implementation strategies.