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An UPLC-ESI-MS/MS Assay Using 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate Derivatization for Targeted Aminio Acid Analysis: Application to Screening of Arabidopsis thaliana Mutants (open access)

An UPLC-ESI-MS/MS Assay Using 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate Derivatization for Targeted Aminio Acid Analysis: Application to Screening of Arabidopsis thaliana Mutants

This article presents a method that enables thirty-eight metabolites (proteinogenic amino acids and related compounds) to be analyzed, with an improved sensitivity of 1 to 5 orders of magnitude compared to existing methods.
Date: July 6, 2012
Creator: Salazar, Carolina; Armenta, Jenny M. & Shulaev, Vladimir
Object Type: Article
System: The UNT Digital Library
Biocultural homogenization: Exotism of the femenine landscape of latin america (open access)

Biocultural homogenization: Exotism of the femenine landscape of latin america

Article discusses the importance of valuing an alternative, ecological, aesthetic and post-modern-exotic hermeneutic in viewing Latin America, and discusses the colonial impression of a "exotic" Latin America.
Date: June 17, 2018
Creator: Castellanos, Angelina Paredes & Rozzi, Ricardo, 1960-
Object Type: Article
System: The UNT Digital Library
Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro (open access)

Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro

The article looks at antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line.
Date: April 15, 2011
Creator: Carraher, Charles E., Jr.; Roner, Michael R.; Shahi, Kimberly & Barot, Girish
Object Type: Article
System: The UNT Digital Library
Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers (open access)

Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers

This article examines the use of metal-containing polymers as a novel class of antivirals. Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth.
Date: May 27, 2011
Creator: Roner, Michael R.; Carraher, Charles E., Jr.; Shahi, Kimberly & Barot, Girish
Object Type: Article
System: The UNT Digital Library
Engineering Disease Resistance in Plants: An Overview (open access)

Engineering Disease Resistance in Plants: An Overview

This book chapter gives an overview of engineering disease resistance in plants.
Date: 1995
Creator: Dixon, R. A.; Paiva, Nancy L. & Bhattacharyya, Madan Kumar
Object Type: Book Chapter
System: The UNT Digital Library
Evidence that Mono-ADP-Ribosylation of CtBP1/BARS Regulates Lipid Storage (open access)

Evidence that Mono-ADP-Ribosylation of CtBP1/BARS Regulates Lipid Storage

Article on evidence that mono-ADP-ribosylation of CtBP1/BARS regulates lipid storage.
Date: May 30, 2007
Creator: Bartz, René; Seemann, Joachim; Zehmer, John K.; Serrero, Ginette; Chapman, Kent D.; Anderson, Richard G. W. et al.
Object Type: Article
System: The UNT Digital Library
Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo (open access)

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

Article on the inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo.
Date: March 21, 2014
Creator: Sethi, Gautam; Chatterjee, Snehajyoti; Rajendran, Peramaiyan; Li, Feng; Shanmugam, Muthu K.; Wong, Kwong Fai et al.
Object Type: Article
System: The UNT Digital Library
NPP-16/Nup50 Function and CDK-1 Inactivation Are Associated with Anoxia-induced Prophase Arrest in Caenorhabditis elgans (open access)

NPP-16/Nup50 Function and CDK-1 Inactivation Are Associated with Anoxia-induced Prophase Arrest in Caenorhabditis elgans

Article discussing how NPP-16/Nup50 function and CDK-1 inactivation are associated with anoxia-induced prophase arrest in Caenorhabditis elegans.
Date: March 1, 2010
Creator: Hajeri, Vinita A.; Little, Brent A.; Ladage, Mary L. & Padilla, Pamela A.
Object Type: Article
System: The UNT Digital Library
The neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line (open access)

The neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line

This article discusses the neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line.
Date: December 10, 2009
Creator: Duncan, Scott R.; Chapman, Kent D. & Koulen, Peter
Object Type: Article
System: The UNT Digital Library
RNA helicase DP103 and TAK1: a new connection in cancer (open access)

RNA helicase DP103 and TAK1: a new connection in cancer

Article on new markers of tumor metastasis. The authors found that expression of DP103 was significantly upregulated in the metastatic basal subtype of breast cancers in 3 independent cohorts. This elevated DP103 expression correlated with metastatic breast cancer gene signatures and was strongly associated with patient survival. This study provides the first evidence that the RNA helicase DEAD-box protein DP103 is an NF-kB target that could form part of a positive feedback loop contributing to DP103- mediated regulation of TAK1 kinase activity on the major NF-kB kinase IKK2, thus implicating DP103 in the maintenance of this oncogenic signaling arm in human cancer.
Date: May 6, 2015
Creator: Shin, Eun Myoung; Osato, Motomi; Kumar, Alan Prem & Tergaonkar, Vinay
Object Type: Article
System: The UNT Digital Library
In situ cardiac performance of Atlantic cod (Gadus morhua) at cold temperatures: long-term acclimation, acute thermal challenge and the role of adrenaline (open access)

In situ cardiac performance of Atlantic cod (Gadus morhua) at cold temperatures: long-term acclimation, acute thermal challenge and the role of adrenaline

This article measures the cardiac performance of Newfoundland Atlantic cod (Gadus morhua). The results: (1) show that maximum performance of the isolated cod heart is not compromised by exposure to cold temperatures; and (2) support data from other studies, which show that, in contrast to salmonids, cod cardiac performance/myocardial contractility is not dependent upon humoral adrenergic stimulation.
Date: November 15, 2012
Creator: Lurman, Glenn J. & Petersen, L. H.
Object Type: Article
System: The UNT Digital Library
Acid-base regulation in the air-breathing swamp eel (Monopterus albus) at different temperatures (open access)

Acid-base regulation in the air-breathing swamp eel (Monopterus albus) at different temperatures

Article describes study in which researchers characterized the influence of temperature on arterial acid–base balance and intracellular pH (pHi) in the bimodal-breathing swamp eel, Monopterus albus.
Date: February 27, 2018
Creator: Thinh, Phan Vinh; Phuong, Nguyen Thanh; Brauner, Colin J.; Huong, Do Thi Thanh; Wood, Andrew T.; Kwan, Garfield T. et al.
Object Type: Article
System: The UNT Digital Library
Effects of chronic exposure to 12‰ saltwater on the endocrine physiology of juvenile American alligator (Alligator mississippiensis) (open access)

Effects of chronic exposure to 12‰ saltwater on the endocrine physiology of juvenile American alligator (Alligator mississippiensis)

Article describes experiment in which juvenile alligators were exposed to 12‰ saltwater for 5 weeks to determine the effects of chronic exposure to saline environments.
Date: July 30, 2018
Creator: Faulkner, P. C.; Burleson, Mark L.; Simonitis, L.; Marshall, C.D.; Hala, D. & Petersen, L. H.
Object Type: Article
System: The UNT Digital Library
Rapid embryonic accretion of docosahexaenoic acid (DHA) in the brain of an altricial bird with an aquatic-based maternal diet (open access)

Rapid embryonic accretion of docosahexaenoic acid (DHA) in the brain of an altricial bird with an aquatic-based maternal diet

This article communicates the results of a study conducted on red-winged blackbirds where brain phospholipid composition during development was measured and diet was manipulated. The dietary study confirmed that nestling brains are sensitive to fatty acid supply. The findings of this article suggest that Red-winged blackbirds may be able to advance cognitive development relative to other altricial species owing to their aquatic maternal diet.
Date: July 23, 2018
Creator: Price, Edwin R.; Sirsat, Sarah K. G.; Sirsat, Tushar S.; Venables, Barney J. & Dzialowski, Edward M. (Edward Michael)
Object Type: Article
System: The UNT Digital Library
Constraints-based stoichiometric analysis of hypoxic stress on steroidogenesis in fathead minnows, Pimephales promelas (open access)

Constraints-based stoichiometric analysis of hypoxic stress on steroidogenesis in fathead minnows, Pimephales promelas

This article presents a study in which an in silico genome-scale metabolic model of steroidogenesis is used to investigate the effects of hypoxic stress on steroid hormone productions in fish. This article introduces a powerful model for pathway analysis that can lend insights on the effects of various stressor scenarios on metabolic functions.
Date: May 15, 2012
Creator: Hala, David; Petersen, Lene H.; Martinovic, Dalma & Huggett, Duane B.
Object Type: Article
System: The UNT Digital Library
Convective oxygen transport during development in embryos of the snapping turtle Chelydra serpentina (open access)

Convective oxygen transport during development in embryos of the snapping turtle Chelydra serpentina

This article describes a study investigating the maturation of convective oxygen transport in embryos of the snapping turtle (Chelydra serpentina). Measurements included: mass, oxygen consumption, heart rate, blood oxygen content and affinity and blood flow distribution at 50%, 70% and 90% of the incubation period.
Date: September 24, 2018
Creator: Sartori, Marina R.; Kohl, Zachary F.; Taylor, Edwin W.; Abe, Augusto S. & Crossley, Dane A., II
Object Type: Article
System: The UNT Digital Library

Developmental phenotypic plasticity helps bridge stochastic weather events associated with climate change

This article posits that the frequently abrupt environmental changes accompanying much longer-term general climate change require consideration of the true nature of environmental change coupled with an expansion of focus to consider developmental phenotypic plasticity.
Date: May 10, 2018
Creator: Burggren, Warren W.
Object Type: Article
System: The UNT Digital Library
Pulmonary compliance and lung volume varies with ecomorphology in anuran amphibians: implications for ventilatory-assisted lymph flux (open access)

Pulmonary compliance and lung volume varies with ecomorphology in anuran amphibians: implications for ventilatory-assisted lymph flux

This article examining the correlation between pulmonary compliance, lung volume, and lymph flux rates in anurans. The findings of this article suggest that lymph mobilization capacity may explain some of the variation in pulmonary compliance and lung volume in anurans.
Date: October 1, 2011
Creator: Hedrick, Michael; Hillman, Stanley S.; Drewes, Robert C. & Withers, Philip C.
Object Type: Article
System: The UNT Digital Library
Xenopus and the art of oxygen maintenance (open access)

Xenopus and the art of oxygen maintenance

This column article discusses the impact of Robert Boutillier and Graham Shelton's 1986 Journal of Experimental Biology paper "Gas exchange, storage and transport in voluntarily diving Xenopus laevis."
Date: November 15, 2017
Creator: Tattersall, Glenn & Burggren, Warren W.
Object Type: Article
System: The UNT Digital Library
An intimate collaboration between peroxisomes and lipid bodies (open access)

An intimate collaboration between peroxisomes and lipid bodies

Article on an intimate collaboration between peroxisomes and lipid bodies.
Date: May 30, 2006
Creator: Binns, Derk Douglas; Januszewski, Tom; Chen, Yue; Hill, Justin; Markin, Vladislav S.; Zhao, Yingming et al.
Object Type: Article
System: The UNT Digital Library
The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets (open access)

The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets

Article on yeast lipin orthologue Pah1p and its importance for biogenesis of lipid droplets.
Date: March 21, 2011
Creator: Adeyo, Oludotun; Horn, Patrick J.; Lee, SungKyung; Binns, Derk Douglas; Chandrahas, Anita; Chapman, Kent D. et al.
Object Type: Article
System: The UNT Digital Library
Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells (open access)

Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells

This article shows that small hairpin RNA-mediated suppresion of NAF-1 results in the activation of apoptosis in epithelial breast cancer cells and xenograft tumors.
Date: November 11, 2015
Creator: Holt, Sarah H.; Darash-Yahana, Merav; Sohn, Yang Sung; Song, Luhua; Karmi, Ola; Tamir, Sagi et al.
Object Type: Article
System: The UNT Digital Library
The membrane pacemaker hypothesis: novel tests during the ontogeny of endothermy (open access)

The membrane pacemaker hypothesis: novel tests during the ontogeny of endothermy

Article explores the ‘membrane pacemaker’ hypothesis which proposes a biochemical explanation for among-species variation in resting metabolism, based on the positive correlation between membrane docosahexaenoic acid (DHA) and metabolic rate. The authors tested this hypothesis using a novel model, altricial red-winged blackbird nestlings, predicting that the proportion of DHA in muscle and liver membranes should increase with the increasing metabolic rate of the nestling as it develops endothermy. In support of the membrane pacemaker hypothesis, DHA proportions increased in membranes from pectoralis muscle, muscle mitochondria and liver during post-hatch development. By contrast, elevated dietary DHA had no effect on resting metabolic rate, despite causing significant changes to membrane lipid composition.
Date: March 29, 2018
Creator: Price, Edwin R.; Sirsat, Tushar S.; Sirsat, Sarah K. G.; Curran, Thomas; Venables, Barney J. & Dzialowski, Edward M. (Edward Michael)
Object Type: Article
System: The UNT Digital Library
Parental stressor exposure simultaneously conveys both adaptive and maladaptive larval phenotypes through epigenetic inheritance in the zebrafish (Danio rerio) (open access)

Parental stressor exposure simultaneously conveys both adaptive and maladaptive larval phenotypes through epigenetic inheritance in the zebrafish (Danio rerio)

This article is a study using crude oil as an example of an environmental stressor in adult zebrafish. The offspring obtained were then assessed for transgenerational epigenetic transfer of oil-induced phenotypes. The authors conclude that epigenetic transgenerational inheritance can lead to an immediate and simultaneous inheritance of both beneficial and maladaptive traits in a large proportion of the F1 larvae. The adaptive responses may help fish populations survive when facing transient environmental stressors.
Date: September 5, 2019
Creator: Bautista, Naim M. & Burggren, Warren W.
Object Type: Article
System: The UNT Digital Library