Rifazone-8{sub 2} (R-8{sub 2}), a new rifamycin derivative, is shown to preferentially inhibit the growth of virus-transformed chick cells in culture. Macromolecular synthesis and glucose uptake of transformed cells are also appreciably decreased in the presence of low concentrations of R-8{sub 2} where the normal cells appear unaffected. While R-8{sub 2} is shown to be a selective inhibitor of RNA-directed DNA polymerase in vitro, its action on the growth of transformed cells may involve some other mechanism.

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In developing radiation detection instrumentation at Rocky Flats, a system concept using plug-in modules was planned. Losses of operational time due to maintenance are drastically reduced as a malfunctioning module can be replaced within minutes. Versatility is another advantage of the modular concept and a particular module can be used in many different system designs. A significant cost savings in system development can also be realized. The scalers described are housed in one-wide Nuclear Instrumentation Bin (NIM-BIN) modules. The design incorporates the latest in COS/MOS (complementary symmetry metal-oxide semiconductor) integrated circuitry, featuring low power, low cost, and high reliability. These inodules were developed specifically for radiation detection systems. Model 24370-31 is used in gross alpha detection systems. Model 27213- 30 appears in a medical wound-counter system, but can be used also in a gamma spectrometer system, or in other related systems. Operational procedures and servicing of units are included. (auth)

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