Income, ethnicity, education, and occupation are examples of socio-economic factors associated with the occurrence of disease, whether an investigation focuses on an individual or on an aggregation of individuals. In this study, data aggregated to the county level are used to explore two issues - geographic variation and geographic covariation of ten selected causes of death in the United States. The counties of the United States are characterized by 15 socio-economic variables and age-adjusted mortality rates for the ten selected causes of death. The observed variation among the US counties, as measured by the socio-economic variables, is first assessed, then the geographic variation and covariation are described for each cause of death and, finally, the covariation among causes of death is analyzed after adjusting for the influences of the measured sources of county variation.

This document contains excerpts from the proceedings of the conference on Technology-based Confidence Building: Energy and the Environment.'' It contains the agenda for the conference and a document on Global Warming and Energy Use;'' a presentation on from Militarism to Environmentalism: a New Focus of US-Soviet Relations;'' a workshop on environmental challenges; a summary address on Science, Technology, and World Affairs;'' an address entitled Energy: the Coin of International Understanding;'' and concluding remarks.

The procedure for installing Superconducting Super Collider (SSC) dipoles in their respective cryostats involves aligning the average direction of their field with the vertical to an accuracy of 0.5 mrad. The equipment developed for carrying on these measurements is described and the measurements performed on the first few prototypes SSC magnets are presented. The field angle as a function of position in these 16.6 m long magnets is a characteristic of the individual magnet with possible feedback information to its manufacturing procedure. A comparison of this vertical alignment characteristic with a magnetic field intensity (by NMR) characteristic for one of the prototypes is also presented. 5 refs., 7 figs.

Research into deuterium-from-protium isotope separation via both metal hydride chromatography and CO/sub 2/ laser multiple-photon dissociation (MPD) of trifluoromethane (CDF/sub 3//CHF/sub 3/) is discussed. Several new classes of alloy compositions, including Mg-rare earth, NiTi/sub x/, and (Ca+Ce,Zr,Ti)./sub 8//sup -/Ni/sub 4/Cu compounds, were evaluated for chromatograhic isotope separation; no tested alloy exhibited properties suitable for commercial deuterium separation. For deuterium separation by MPD of CDF/sub 3/, construction of a CO/sub 2/ laser system was completed that is capable of delivering either 2 nsec short pulses at a single wavelength or 200 nsec long pulses simulatneously at two different laser frequencies. The wavelength dependence of single-line multiple-photon dissociation probability of CDF/sub 3/ was measured, and is reported here. Deuterium separation by CO/sub 2/ laser photolysis of CDF/sub 3//CHF/sub 3/ near 10.3 ..mu.. using approx. 2 nsec pulses still appears to be a commercially viable process for heavy water production.

We are using a transponding geostationary satellite to collect surface environmental data to describe the fate of soil-borne radionuclides. The remote, former atomic testing grounds at the Eniwetok and Bikini Atolls present a difficult environment in which to collect continuous field data. Our land-based, solar-powered microprocessor and environmental data systems remotely acquire measurements of net and total solar radiation, rain, humidity, temperature, and soil-water potentials. For the past year, our water flux model predicts wet season plant transpiration rates nearly equal to the 6 to 7 mm/d evaporation pan rate, which decreases to 2 to 3 mm/d for the dry season. Radioisotopic analysis confirms the microclimate-estimated 1:3 to 1:20 soil to plant /sup 137/Cs dry matter concentration ratio. This ratio exacerbates the dose to man from intake of food plants. Nephelometer measurements of airborne particulates presently indicate a minimum respiratory radiological dose.

We present a solid state accelerator concept utilizing particle acceleration along crystal channels by longitudinal electron plasma waves in a metal. Acceleration gradients of order 100 GV/cm are theoretically possible, but channeling radiation limits the maximum attainable energy to 10/sup 5/ TeV for protons. Beam dechanneling due to multiple scattering is substantially reduced by the high acceleration gradient. Plasma wave dissipation and generation in metals are also discussed.

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The TOUGH code developed at Lawrence Berkeley Laboratory (LBL) is being extensively used to numerically simulate the thermal and hydrologic environment around nuclear waste packages in the unsaturated zone for the Yucca Mountain Project. At the Lawrence Livermore National Laboratory (LLNL) we have rewritten approximately 80 percent of the TOUGH code to increase its speed and incorporate new options. The geometry of many problems requires large numbers of computational elements elements in order to realistically model detailed physical phenomena, and, as a result, large amounts of computer time are needed. In order to increase the speed of the code we have incorporated fast linear equation solvers, vectorization of substantial portions of code, improved automatic time stepping, and implementation of table look-up for the steam table properties. These enhancements have increased the speed of the code for typical problems by a factor of 20 on the Cray 2 computer. In addition to the increase in computational efficiency we have added several options: vapor pressure lowering; equivalent continuum treatments of fractures; energy and material volumetric, mass and flux accounting; and Stefan-Boltzmann radiative heat transfer. 5 refs.

The research objectives and goals of 1983--84 to date include further investigation of 1-halogenated and B-/C-ring halogenated and radio halogenated estradiol derivatives for potential use as receptor-binding radiopharmaceuticals. Our group has devised synthetic routes to 1-bromo, 1-chloro- and 1-fluoroestradiol via electrophilic halogenation of the aromatic A-ring. Work is presently underway to prepare the 1-iodo derivative using a similar methodology. The 11 {beta}-methoxy, 17 {alpha}-ethynyl and 11 {beta}-methoxy-17 {alpha}-ethynyl derivatives are of synthetic interest if the in vitro binding affinities of the parent compounds are favorable. The B- and C-ring vinyl halides' which were proposed in the current contract could not be prepared using the hydrazone intermediates described. Presently, other methods which show promise are being investigated. Stable B-ring brominated derivatives of estradiol have been prepared by our group. Their in vitro properties are currently under investigation. 15 refs.

Stimulated Raman scattering is of concern to laser fusion since it can create a hot electron environment which can increase the difficulty of achieving high final fuel densities. In earlier experiments with one micron laser light, the energy measured in Raman-scattered light has been insignificant. But these experiments were done with, at most, about 100 joules of laser energy. The Raman instability has a high threshold which also requires a large plasma to be irradiated with a large diameter spot. Only with a long interaction length can the Raman-scattered light wave convectively grow to a large amplitude, and only in recent long pulse, high energy experiments (4000 joules in 2 ns) at the Shiva laser facility have we observed as much as several percent of the laser light to be Raman-scattered. We find that the Raman instability has a much lower intensity threshold for longer laser pulselength and larger laser spot size on a solid target.

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The laboratory facility for photochemical tritium separation research has been completed. Methods for synthesizing the mono-tritiated halogenated methanes have been developed. Notably, CTF/sub 3/ has been synthesized and spectrally analyzed. The CTF/sub 3/ vibrational frequencies are found to be in quite good agreement with earlier calculations.