Fourteen dogs located on the lee side of planted gravel, of a concrete- block wall, and of glass mounted in the open and in houses were exposed to the environmental variations associated with full-scale nuclear detonations. Aluminum foil was used to protect the animals from thermal effects. The missile environment was monitored through the use of quantitutive missile-trapping techniques. Pressure-time variations in the environment were also recorded. Biologic damage from overpressure and missiles was determined, and the associations between physical envtronmental factors and biologic response were noted and analyzed. The feasibility of utilizing ninssile data, along with other available information from the literature, as a means of quantitutively assesing biologic hazard was estublished by the close correspondence between observed and predicted dangerous wounds. This test provided full-scale validation of procedures and experimsnts worked out chiefly in the laboratory. (auth)