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Military Family Tax Relief Act of 2003
None
Date:
November 28, 2003
Creator:
unknown
System:
The UNT Digital Library
Novel in Vivo Imaging Techniques for Trafficking the Behavior of Subventricular Zone Neural Stem Cells (SVZSC) and SVZSC Induced Functional Repair
Adult progenitor cells hold promise for therapeutic treatment where there has been a disabling loss of function due to death of cells from trauma, disease or aging. However, it will be essential in clinical application to be able to follow the fate of the transplanted cells over time using in vivo tracking methods. We have developed protocol for labeling of progenitor cells to monitor cell trafficking by high resolution magnetic resonance imaging (MRI) and super high resolution positron emission tomography (PET). We have transfected rat subventricular zone stem cells (SVZ, progenitor cell line) and another control cell line (PC12, pheochromocytoma cells) utilizing super paramagnetic iron oxide and poly-L-lysine complex for MR imaging or radiolabeling with 18F-fluor deoxy-D- glucose for PET imaging. The labeled cells were transplanted into the rostral migratory stream (RMS) or striatum of normal or 6-hydroxydopamine lesioned Spraque-Dawley rats. Longitudinal MRI studies (up to 40 days) showed that transplantation site has significant impact to the fate of the cells; when SVZ cells were transplanted into the RMS, cells migrated several centimeter into the olfactory bulb; after transplantation into the striatum, the migration was minimal, only 2 mm. PC 12 cells grew a massive tumor after the striatal implantation …
Date:
November 28, 2003
Creator:
Brownell, Anna-Liisa
System:
The UNT Digital Library
The Vietnam-U.S. Normalization Process
None
Date:
November 28, 2003
Creator:
Manyin, Mark E.
System:
The UNT Digital Library