Technical report covering classified activities of the Department of Reactor Science and Engineering since its inception in January, 1949. This if focused on the research, evaluation, and redesign of the reactor as well as the tests on various reactor components and engineering design to correct structural defects as they have become evident through reactor use.

Technical report including multiple lectures on nuclear science and engineering, planned to survey the theories, designs, operations, and experimental facilities of the Brookhaven Nuclear Reactor.

Technical report indicating the progress made in the first quarter of 1950 only for the classified projects in the Reactor Science and Engineering Department, including continuous processing breeder blanket studies, sub-critical experiments, and metallurgical experiments like fluid fuels, materials testing, reactor reconstruction, and reactor component testing and service.

Technical report outlining the progress of reactor completion and startup events by the Reactor Theory, Physics, Radioisotope Development, Geology, Meteorology, Waste Concentration, and Waste Disposal groups in the Reactor Science and Engineering Department of Brookhaven National Laboratory.

Technical report investigating the distribution of rare earth elements between a liquid bismuth-uranium solution and fused KCI-LiCi mixtures. Report warrants further research on the liquid bismuth-uranium-fused salt system due to the benefit of continuous fission removal processes.

Technical report presenting preliminary results obtained in the static corrosion test program to screen promising construction materials for a proposed liquid fuel power breeder reactor.

In discussing this subject, data on radiation induced mammary gland neoplasia in the rat indicating that direct interaction between the radiation and target tissue is necessary for maximum neoplasia induction will be presented mainly. Other types of radiation induced neoplasia, in which little or no information on the mechanisms involved is available, will be discussed briefly. In particular, investigations on radiation induced mouse lymphoma will be reviewed, in which neoplasia appears to be an abscopal effect. Implications of these data will be discussed, particularly with regard to possible mechanisms involved, and extrapolation to man.

In the vast field of radiation pathology we find pathologists, anatomists, and even physiologists busily at work, but the radiobiologist is conspicuously absent, although, according to Zirkle (1959), this field is clearly within his domain. Perhaps it is wise to take this broad hint of the scientifically so well equipped radiobiologist and to stay clear from an area in which an incalculable array of variables makes clearcut experimentation a hopeless venture, a priori. Perhaps it would be better if the pathologist, who must study pertinent material, restricts himself humbly to the recording of his observations, refraining from any attempt at interpretation. On the other hand, since seemingly audacious speculation has borne fruit in the past and the value of the information that results, if the speculation proves to be correct, is worth many times the effort, there is obvious justification for a thesis on the mechanism of delayed radionecrosis.

This report reviews the published work on the thermochemistry of the liquid alloys of bismuth with Th, Pa, U, and Pu and the high-yield fission products, and presents in a unified form the authors' own results in this field.

Technical report describing "A means for automatically determining the coordinates of a point at the center of a bubble chamber track." from the abstract.

Study comparing high resolution autoradiographic techniques using labeled DNA precursors and chemical methods of comparing mitotic indexes to evaluate tissue responses under continuous irradiation.

Technical report investigates creating a microbeam of deuterons to simulate cosmic rays and the results of brain irradiation, irradiation of the eye, and irradiation of hair follicles of mice. The report's conclusion was that "astronauts exposed to heavy primary particles over a period of some weeks would be expected to develop gray hairs, but this is the only significant biological damage they would suffer."

Report issued by the Brookhaven National Laboratory discussing papers presented at the International Conference on Fundamental Aspects of Weak Interactions. Each paper that was presented at the conference is included. This report includes tables, illustrations, and photographs.

Report issued by the Brookhaven National Laboratory containing conference proceedings from the first three sessions of the Symposium in Biology, held June 3-5, 1968. It includes research and papers discussing developments in the structure, function, and evolution in proteins with tables, illustrations, and photographs.

Numerous studies on the effects of radiation on the central nervous system used traditional pathomorphological changes as parameters of radiosensitivity, but pathogenesis and mechanisms of radiation injury to the nervous tissue are still little understood. Furthermore, the great discrepancy of dose requirement leading to physiological responses and on the other hand to pathomorphological changes in the central nervous system is not satisfactorily explained.

We consider the kinetic isotope effect in three center reactions of the type of A+BC→AB+C. Such model calculations are a good approximation to primary hydrogen isotope effects. For abstraction or transfer reactions, B becomes H, D, or T. The dynamics of the three storm system are calculated for a general quadratic potential, with the assumption that the potential energy is constant along the reaction coordinate (flat top barrier). This model system can be calculated in detail and serves to illustrate the relationship between kinetic isotope effect and chemical bonding in the transition state. The statistical mechanical part of the calculation can be carried out exactly within the framework transition state theory or in any one of a number of approximations. The γ bar method gives particularly good insight into the chemistry of the problem with a minimum of arithmetic.

The biological effects of various doses of radiation in plants are reviewed. Data are reported from a study of the effects of gamma radiation on a terrestrial ecosystem in which oak and pine are the principal tree species. Exposure rates around a 9500-C Cs¹³⁷ source varied from several thousand r/day within a few meters to about 2 r/day at 130 m delivered during a 20-hr day. Measurements were made of changes in the populations of species which formed the ecosystem, the rates of fixation, paths of energy movement through the system, differences in radiosensitivity among the plant species, and radiation effects on host-parasite relations. Results are discussed from the standpoint of the results of contamination of the environment with radioactive debris.

The first national Technical Conference on Air Pollution (1) held in this city in 1950 included eight papers on meteorology; the present session contains one. On this basis, one night conclude that recent progress in meteorology has been virtually nonexistent or that the importance of meteorological factors has been diminishing, Neither could be further from the truth, as the number and quality of papers relating to air pollution meteorology in recent scientific and technical sessions will attest. It is particularly appropriate to review the status of meteorological "know-how" at this time, because of the many situations in which the ultimate capability of the atmosphere to absorb pollution is in question. Both in connection with highly toxic materials on the one hand and the "megalopolis" on the other, estimates of the "atmospheric sewer capacity" are becoming increasingly necessary to industrial and municipal planning.

In brief, these facilities consist of a 250 KvP X-ray generator; two areas of a research reactor, one a well thermalized unit of moderate capacity and a larger area with a mixed thermal and fast neutron distribution, all of which are used for brief, acute exposure. A 10 acre field, currently with almost 4000 curies of cobalt 60, serves to irradiate entire plants for either short or long periods of time. Recently, the flux density of the thermal column was increased by a factor of 5 over the original density. This was accomplished by lowering the thermal column 12 inches deeper into the reactor shield. Fast neutrons at this higher flux density are also available to the cooperator. An additional facility available to the program is the array of kilocurie gamma sources in the Nuclear Engineering Department of Brookhaven National Laboratory.

Kalanchoe seedlings were exposed to 330 r/20 hrs/day from a Co60 source. Samples were harvested weekly. No new leaves were produced after initial exposure to irradiation. Mitosis in the apical meristem appears to have been suppressed. However, the axillary meristem and the cambium continue their activity. This results in a much broadened stem tip with enlarged cells, supported by a stout internode in which cell size has remained relatively normal but cell number has increased. After about 26 days of exposure, meristematic activity in the shoot apex region appears to resume. This results in the formation of growth centers which can give rise to leaves or malformed structures. The original phyllotaxy is not recovered. It is suggested that this resumption of growth may be an instance of adaptation to irradiation.

During the past year notable progress was made in several laboratories on design for linear accelerators in the energy range up to and above 1 Bev. Interest in linacs for this energy centers on two possible applications: first, as injectors for 300 to 1000 Bev synchrotrons, and second, as sources of intense meson beams. To review this progress, a conference jointly sponsored by the Brookhaven National Laboratory and Yale University was held at Brookhaven during the week of August 20, 1962.