This thesis presents an optimized drive signal control system for a 2.5 GHz Doherty power amplifier (PA). The designed system enables independent control of the amplitudes and phases of the drive signals fed to the inputs of two parallel PAs. This control system is demonstrated here for Doherty PA architecture with a combiner network which is used as an impedance inversion between the path of two parallel connected PAs. Independent control of the inputs is achieved by incorporating a variable attenuator (VA) and a variable phase shifter (VPS) in each of the two parallel paths. Integrating VA and VPS allows driving varying power levels with an arbitrary phase difference between the individual parallel PAs. A Combiner network consists of a quarter-wave transmission line at the output of the main power amplifier, which is used to invert the impedance between the main and peaking transistor. The specific VA (Qorvo QPC6614) and VPS (Qorvo QPC2108) components that are used for the test system provide an amplitude attenuation range from 0.5 dB to 31.5 dB with a step size of 0.5 dB and a phase range from 0◦ to 360◦ for a step size of 5.6◦at the intended operating frequency of 2.5 GHz, …

The survival rate for a suddent cardiac arrest (SCA) is incredibly low, with less than one in ten surviving; most SCAs occur outside of a hospital setting. There is a need to develop an effective and efficient system that can sense, communicate and remediate potential SCA situations on a near real-time basis. This research presents a novel Zeolite-PDMS-based optically unobtrusive flexible dry electrodes for biosignal acquisition from various subjects while at rest and in motion. Two zeolite crystals (4A and 13X) are used to fabricate the electrodes. Three different sizes and two different filler concentrations are compared to identify the better performing electrode suited for electrocardiogram (ECG) data acquisition. A low-power, low-noise amplifier with chopper modulation is designed and implemented using the standard 180nm CMOS process. A commercial off-the-shelf (COTS) based wireless system is designed for transmitting ECG signals. Further, this dissertation provides a framework for Machine Learning Classification algorithms on large, open-source Arrhythmia and SCA datasets. Supervised models with features as the input data and deep learning models with raw ECG as input are compared using different methods. The machine learning tool classifies the datasets within a few minutes, saving time and effort for the physicians. The experimental results …

The key requirements of a reliable neural signal recording system include low power to support long-term monitoring, low noise, minimum tissue damage, and wireless transmission. The neural spikes are also detected and sorted on-chip/off-chip to implement closed-loop neuromodulation in a high channel count setup. All these features together constitute an empirical neural recording system for neuroscience research. In this prospectus, we propose to develop a neural signal acquisition system with wireless transmission and feature extraction. We start by designing a prototype entirely built with commercial-off-the-shelf components, which includes recording and wireless transmission of synthetic neural data and feature extraction. We then conduct the CMOS implementation of the low-power multi-channel neural signal recording read-out circuit, which enables the in-vivo recording with a small form factor. Another direction of this thesis is to design a self-powered motion tracking read-out circuit for wearable sensors. As the wearable industry continues to advance, the need for self-powered medical devices is growing significantly. In this line of research, we propose a self-powered motion sensor based on reverse electrowetting-on-dielectric (REWOD) with low-power integrated electronics for remotely monitoring health conditions. We design the low-power read-out circuit for a wide range of input charges, which is generated from the …

This dissertation is particularly focused on a novel approach of a wirelessly powered neuromodulation system for chronic patients. The inductively coupled transmitter (TX) and receiver (RX) coils are designed through optimization to achieve maximum efficiency. A power management unit (PMU) consisting of a voltage rectifier, voltage regulator along with a stimulation circuitry is also designed to provide pulse stimulation to genetically modified neurons. For continuous health monitoring purposes, the response from the brain due to stimulation needs to be recorded and transmitted wirelessly outside the brain for analysis. A low-power high-data duty-cycled impulse-radio ultra-wideband (IR-UWB) transmitter is designed and implemented using the standard CMOS process. Another focus of this dissertation is the design of a reverse electrowetting-on-dielectric (REWOD) based energy harvesting circuit for wearable sensor applications which is capable of generating a very low-frequency signal from motion activity such a walking, running, jogging, etc. A commercial off-the-shelf (COTS) based and on-chip based energy harvesting circuit is designed for very low-frequency signals. The experimental results show promising progress towards the advancement in the wirelessly powered neuromodulation system and building the self-powered wearable sensor.