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Predicting cancer outcome
We read with interest the paper by Michiels et al on the prediction of cancer with microarrays and the commentary by Ioannidis listing the potential as well as the limitations of this approach (February 5, p 488 and 454). Cancer is a disease characterized by complex, heterogeneous mechanisms and studies to define factors that can direct new drug discovery and use should be encouraged. However, this is easier said than done. Casti teaches that a better understanding does not necessarily extrapolate to better prediction, and that useful prediction is possible without complete understanding (1). To attempt both, explanation and prediction, in a single nonmathematical construct, is a tall order (Figure 1).
Date:
March 24, 2005
Creator:
Gardner, S N & Fernandes, M
Object Type:
Article
System:
The UNT Digital Library
Oligonucleotide and Long Polymeric DNA Encoding
This report summarizes the work done at Lawrence Livermore National Laboratory for the Oligonucleotide and Long Polymeric DNA Encoding project, part of the Microelectronic Bioprocesses Program at DARPA. The goal of the project was to develop a process by which long (circa 10,000 base-pair) synthetic DNA molecules could be synthesized in a timely and economic manner. During construction of the long molecule, errors in DNA sequence occur during hybridization and/or the subsequent enzymatic process. The work done on this project has resulted in a novel synthesis scheme that we call the parallel pyramid synthesis protocol, the development of a suit of computational tools to minimize and quantify errors in the synthesized DNA sequence, and experimental proof of this technique. The modeling consists of three interrelated modules: the bioinformatics code which determines the specifics of parallel pyramid synthesis for a given chain of long DNA, the thermodynamics code which tracks the products of DNA hybridization and polymerase extension during the later steps in the process, and the kinetics model which examines the temporal and spatial processes during one thermocycle. Most importantly, we conducted the first successful syntheses of a gene using small starting oligomers (tetramers). The synthesized sequence, 813 base pairs …
Date:
November 24, 2003
Creator:
Miller, E.; Mariella, R. P. Jr.; Christian, A. T.; Gardner, S. N. & Williams, J. M.
Object Type:
Report
System:
The UNT Digital Library
U.S. Circuit and District Court Nominations by President George W. Bush During the 107th-109th Congresses
None
Date:
May 24, 2006
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
The Clifton Record (Clifton, Tex.), Vol. 112, No. 43, Ed. 1 Wednesday, October 24, 2007
Weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.
Date:
October 24, 2007
Creator:
Smith, W. Leon
Object Type:
Newspaper
System:
The Portal to Texas History
The Clifton Record (Clifton, Tex.), Vol. 106, No. 68, Ed. 1 Friday, August 24, 2001
Semi-weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.
Date:
August 24, 2001
Creator:
Smith, W. Leon
Object Type:
Newspaper
System:
The Portal to Texas History
Polarization for Background Reduction in EDXRF - The Technique That Would Not Work
As with all electromagnet radiation, polarization of x-rays is a general phenomenon. Such polarization has been known since the classic experiments of Barkla in 1906. The general implementation of polarization to x-ray analysis had to await the fixed geometry of energy-dispersive systems. The means of optimizing these systems is shown in this review paper. Improved detection limits are the result.
Date:
July 24, 2002
Creator:
Ryon, R W
Object Type:
Article
System:
The UNT Digital Library
The Clifton Record (Clifton, Tex.), Vol. 113, No. 39, Ed. 1 Wednesday, September 24, 2008
Weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.
Date:
September 24, 2008
Creator:
Smith, W. Leon
Object Type:
Newspaper
System:
The Portal to Texas History
The Clifton Record (Clifton, Tex.), Vol. 105, No. 94, Ed. 1 Friday, November 24, 2000
Semi-weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.
Date:
November 24, 2000
Creator:
Smith, W. Leon
Object Type:
Newspaper
System:
The Portal to Texas History
The Clifton Record (Clifton, Tex.), Vol. 108, No. 8, Ed. 1 Friday, January 24, 2003
Semi-weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.
Date:
January 24, 2003
Creator:
Smith, W. Leon
Object Type:
Newspaper
System:
The Portal to Texas History
The Clifton Record (Clifton, Tex.), Vol. 112, No. 4, Ed. 1 Wednesday, January 24, 2007
Weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.
Date:
January 24, 2007
Creator:
Smith, W. Leon
Object Type:
Newspaper
System:
The Portal to Texas History
The Clifton Record (Clifton, Tex.), Vol. 109, No. 48, Ed. 1 Friday, September 24, 2004
Weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.
Date:
September 24, 2004
Creator:
Smith, W. Leon
Object Type:
Newspaper
System:
The Portal to Texas History
The Clifton Record (Clifton, Tex.), Vol. 108, No. 86, Ed. 1 Friday, October 24, 2003
Semi-weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.
Date:
October 24, 2003
Creator:
Smith, W. Leon
Object Type:
Newspaper
System:
The Portal to Texas History
The Goldthwaite Eagle (Goldthwaite, Tex.), Vol. 111, No. 46, Ed. 1 Wednesday, May 24, 2006
Weekly newspaper from Goldthwaite, Texas that includes local, state, and national news along with extensive advertising.
Date:
May 24, 2006
Creator:
Bridges, Steven W.
Object Type:
Newspaper
System:
The Portal to Texas History
The Goldthwaite Eagle (Goldthwaite, Tex.), Vol. 112, No. 28, Ed. 1 Wednesday, January 24, 2007
Weekly newspaper from Goldthwaite, Texas that includes local, state, and national news along with extensive advertising.
Date:
January 24, 2007
Creator:
Bridges, Steven W.
Object Type:
Newspaper
System:
The Portal to Texas History
The Clifton Record (Clifton, Tex.), Vol. 105, No. 24, Ed. 1 Friday, March 24, 2000
Semi-weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.
Date:
March 24, 2000
Creator:
Smith, W. Leon
Object Type:
Newspaper
System:
The Portal to Texas History
The Clifton Record (Clifton, Tex.), Vol. 105, No. 41, Ed. 1 Wednesday, May 24, 2000
Semi-weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.
Date:
May 24, 2000
Creator:
Smith, W. Leon
Object Type:
Newspaper
System:
The Portal to Texas History
The Clifton Record (Clifton, Tex.), Vol. 109, No. 61, Ed. 1 Friday, December 24, 2004
Weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.
Date:
December 24, 2004
Creator:
Smith, W. Leon
Object Type:
Newspaper
System:
The Portal to Texas History
Sapulpa Daily Herald (Sapulpa, Okla.), Vol. 87, No. 88, Ed. 1 Monday, December 24, 2001
Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.
Date:
December 24, 2001
Creator:
Quinnelly, Lorrie J.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Sapulpa Daily Herald (Sapulpa, Okla.), Vol. 86, No. 242, Ed. 1 Sunday, June 24, 2001
Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.
Date:
June 24, 2001
Creator:
Quinnelly, Lorrie J.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Sapulpa Daily Herald (Sapulpa, Okla.), Vol. 85, No. 140, Ed. 1 Saturday, February 24, 2001
Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.
Date:
February 24, 2001
Creator:
Quinnelly, Lorrie J.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Sapulpa Daily Herald (Sapulpa, Okla.), Vol. 87, No. 140, Ed. 1 Sunday, February 24, 2002
Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.
Date:
February 24, 2002
Creator:
Quinnelly, Lorrie J.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Investigations of paleoclimate variations using accelerator mass spectrometry
This project has used Accelerator Mass Spectrometry (AMS) {sup 14}C measurements to study climate and carbon cycle variations on time scales from decades to millennia over the past 30,000 years, primarily in the western US and the North Pacific. {sup 14}C dates provide a temporal framework for records of climate change, and natural radiocarbon acts as a carbon cycle tracer in independently dated records. The overall basis for the study is the observation that attempts to model future climate and carbon cycle changes cannot be taken seriously if the models have not been adequately tested. Paleoclimate studies are unique because they provide realistic test data under climate conditions significantly different from those of the present, whereas instrumental results can only sample the system as it is today. The aim of this project has been to better establish the extent, timing, and causes of past climate perturbations, and the carbon cycle changes with which they are linked. This provides real-world data for model testing, both for the development of individual models and also for inter-model diagnosis and comparison activities such as those of LLNL's PCMDI program; it helps us achieve a better basic understanding of how the climate system works so …
Date:
August 24, 2000
Creator:
Southon, J R; Kashgarian, M & Brown, T A
Object Type:
Report
System:
The UNT Digital Library
Texas Jewish Post (Fort Worth, Tex.), Vol. 54, No. 34, Ed. 1 Thursday, August 24, 2000
Weekly Jewish newspaper from Fort Worth, Texas that includes local, state, and national news along with extensive advertising.
Date:
August 24, 2000
Creator:
Wisch, J. A. & Wisch, Rene
Object Type:
Newspaper
System:
The Portal to Texas History
Single Transverse-Spin Asymmetries at Large-x
The large-x behavior of the transverse-momentum dependent quark distributions is analyzed in the factorization-inspired perturbative QCD framework, particularly for the naive time-reversal-odd quark Sivers function which is responsible for the single transverse-spin asymmetries in various semi-inclusive hard processes. By examining the dominant hard gluon exchange Feynman diagrams, and using the resulting power counting rule, we find that the Sivers function has power behavior (1-x){sup 4} at x {yields} 1, which is one power of (1-x) suppressed relative to the unpolarized quark distribution. These power-counting results provide important guidelines for the parameterization of quark distributions and quark-gluon correlations.
Date:
October 24, 2006
Creator:
Brodsky, Stanley J. & Yuan, Feng
Object Type:
Article
System:
The UNT Digital Library