Parenting self-efficacy refers to the ability of parents to have confidence in their abilities to effectively parent their children. Parenting self-efficacy can be divided into two types: (a) general parenting self-efficacy, which is defined as a parent’s overall sense of ability to effectively parent; and (b) task-specific parenting self-efficacy, which is defined as a parent’s confidence level to perform specific parenting tasks, such as teaching and nurturing (tested in this study). The study applied Bronfenbrenner’s bioecological theory to an analysis of (a) the effect of the HIPPY program in interaction with family and neighborhood variables on parenting self-efficacy and (b) the effect of the interaction of family and neighborhood variables on parenting self-efficacy. A group of 138 HIPPY mothers and a group of 76 comparison mothers who did not receive HIPPY services were surveyed. The sample was largely Hispanic. Results indicated HIPPY predicts task-specific parenting self-efficacy for teaching tasks, but not general parenting self-efficacy or task-specific efficacy for nurturance. Many family variables that reflected Hispanic family values were unique predictors of all three types of parenting self-efficacy, both in analyses involving interactions with HIPPY and with neighborhood variables. Neighborhood variables solely predicted general parenting self-efficacy. Moderation effects were found for …