Susceptibles-infectives-removals (SIR) and its derivatives are the classic mathematical models for the study of infectious diseases in epidemiology. In order to model and simulate epidemics of an infectious disease, a global stochastic field simulation paradigm (GSFS) is proposed, which incorporates geographic and demographic based interactions. The interaction measure between regions is a function of population density and geographical distance, and has been extended to include demographic and migratory constraints. The progression of diseases using GSFS is analyzed, and similar behavior to the SIR model is exhibited by GSFS, using the geographic information systems (GIS) gravity model for interactions. The limitations of the SIR and similar models of homogeneous population with uniform mixing are addressed by the GSFS model. The GSFS model is oriented to heterogeneous population, and can incorporate interactions based on geography, demography, environment and migration patterns. The progression of diseases can be modeled at higher levels of fidelity using the GSFS model, and facilitates optimal deployment of public health resources for prevention, control and surveillance of infectious diseases.

Traditional Public Health decision-support can benefit from the Web and social media revolution. This dissertation presents approaches to mining social media benefiting public health epidemiology. Through discovery and analysis of trends in Influenza related blogs, a correlation to Centers for Disease Control and Prevention (CDC) influenza-like-illness patient reporting at sentinel health-care providers is verified. A second approach considers personal beliefs of vaccination in social media. A vaccine for human papillomavirus (HPV) was approved by the Food and Drug Administration in May 2006. The virus is present in nearly all cervical cancers and implicated in many throat and oral cancers. Results from automatic sentiment classification of HPV vaccination beliefs are presented which will enable more accurate prediction of the vaccine's population-level impact. Two epidemic models are introduced that embody the intimate social networks related to HPV transmission. Ultimately, aggregating these methodologies with epidemic and social network modeling facilitate effective development of strategies for targeted interventions.

People interact with each other through natural language to express feelings, thoughts, intentions, instructions etc. These interactions as a result form relationships. Besides names of relationships like siblings, spouse, friends etc., a number of dimensions (e.g. cooperative vs. competitive, temporary vs. enduring, equal vs. hierarchical etc.) can also be used to capture the underlying properties of interpersonal interactions and relationships. More fine-grained descriptors (e.g. angry, rude, nice, supportive etc.) can also be used to indicate the reasons or social-acts behind the dimension cooperative vs. competitive. The way people interact with others may also tell us about their personal traits, which in turn may be indicative of their probable success in their future. The works presented in the dissertation involve creating corpora with fine-grained descriptors of interactions and relationships. We also described experiments and their results that indicated that the processes of identifying the dimensions can be automated.

In order to run and manage resource-intensive high-performance applications, large-scale computing and storage platforms have been evolving rapidly in various domains in both academia and industry. The energy expenditure consumed to operate and maintain these cloud computing infrastructures is a major factor to influence the overall profit and efficiency for most cloud service providers. Moreover, considering the mitigation of environmental damage from excessive carbon dioxide emission, the amount of power consumed by enterprise-scale data centers should be constrained for protection of the environment.Generally speaking, there exists a trade-off between power consumption and application performance in large-scale computing systems and how to balance these two factors has become an important topic for researchers and engineers in cloud and HPC communities. Therefore, minimizing the power usage while satisfying the Service Level Agreements have become one of the most desirable objectives in cloud computing research and implementation. Since the fundamental feature of the cloud computing platform is hosting workloads with a variety of characteristics in a consolidated and on-demand manner, it is demanding to explore the inherent relationship between power usage and machine configurations. Subsequently, with an understanding of these inherent relationships, researchers are able to develop effective power management policies to optimize …

In this dissertation, we have analyzed various security and trustworthy solutions for modern computing systems and proposed a framework that will provide holistic security and trust for the entire lifecycle of a virtualized workload. The framework consists of 3 novel techniques and a set of guidelines. These 3 techniques provide necessary elements for secure and trusted execution environment while the guidelines ensure that the virtualized workload remains in a secure and trusted state throughout its lifecycle. We have successfully implemented and demonstrated that the framework provides security and trust guarantees at the time of launch, any time during the execution, and during an update of the virtualized workload. Given the proliferation of virtualization from cloud servers to embedded systems, techniques presented in this dissertation can be implemented on most computing systems.