How do the content and writing style of people who drink alcohol beverages stand out from non-drinkers? How much information can we learn about a person's alcohol consumption behavior by reading text that they have authored? This thesis attempts to extend the methods deployed in authorship attribution and authorship profiling research into the domain of automatically identifying the human action of drinking alcohol beverages. I examine how a psycholinguistics dictionary (the Linguistics Inquiry and Word Count lexicon, developed by James Pennebaker), together with Kenneth Burke's concept of words as symbols of human action, and James Wertsch's concept of mediated action provide a framework for analyzing meaningful data patterns from the content of blogs written by consumers of alcohol beverages. The contributions of this thesis to the research field are twofold. First, I show that it is possible to automatically identify blog posts that have content related to the consumption of alcohol beverages. And second, I provide a framework and tools to model human behavior through text analysis of blog data.

Computational modeling is of fundamental significance in mapping possible disease spread, and designing strategies for its mitigation. Conventional contact networks implement the simulation of interactions as random occurrences, presenting public health bodies with a difficult trade off between a realistic model granularity and robust design of intervention strategies. Recently, researchers have been investigating the use of agent-based models (ABMs) to embrace the complexity of real world interactions. At the same time, theoretical approaches provide epidemiologists with general optimization models in which demographics are intrinsically simplified. The emerging study of affiliation networks and co-affiliation networks provide an alternative to such trade off. Co-affiliation networks maintain the realism innate to ABMs while reducing the complexity of contact networks into distinctively smaller k-partite graphs, were each partition represent a dimension of the social model. This dissertation studies the optimization of intervention strategies for infectious diseases, mainly distributed in school systems. First, concepts of synthetic populations and affiliation networks are extended to propose a modified algorithm for the synthetic reconstruction of populations. Second, the definition of multi-coaffiliation networks is presented as the main social model in which risk is quantified and evaluated, thereby obtaining vulnerability indications for each school in the system. Finally, maximization …

With the increasing demand on wireless and portable devices, the radio frequency front end blocks are required to feature properties such as wideband, high frequency, multiple operating frequencies, low cost and compact size. However, the current radio frequency system blocks are designed by combining several individual frequency band blocks into one functional block, which increase the cost and size of devices. To address these issues, it is important to develop novel approaches to further advance the current design methodologies in both space and spectrum domains. In recent years, the concept of artificial materials has been proposed and studied intensively in RF/Microwave, Terahertz, and optical frequency range. It is a combination of conventional materials such as air, wood, metal and plastic. It can achieve the material properties that have not been found in nature. Therefore, the artificial material (i.e. meta-materials) provides design freedoms to control both the spectrum performance and geometrical structures of radio frequency front end blocks and other high frequency systems. In this dissertation, several artificial materials are proposed and designed by different methods, and their applications to different high frequency components and circuits are studied. First, quasi-conformal mapping (QCM) method is applied to design plasmonic wave-adapters and couplers …

Current syndromic surveillance systems utilize centralized databases that are neither scalable in storage space nor in computing power. Such systems are limited in the amount of syndromic data that may be collected and analyzed for the early detection of infectious disease outbreaks. However, with the increased prevalence of international travel, public health monitoring must extend beyond the borders of municipalities or states which will require the ability to store vasts amount of data and significant computing power for analyzing the data. Intelligent mobile agents may be used to create a distributed surveillance system that will utilize the hard drives and computer processing unit (CPU) power of the hosts on the agent network where the syndromic information is located. This thesis proposes the design of a mobile agent-based syndromic surveillance system and an agent decision model for outbreak detection. Simulation results indicate that mobile agents are capable of detecting an outbreak that occurs at all hosts the agent is monitoring. Further study of agent decision models is required to account for localized epidemics and variable agent movement rates.

A novel scheme of optimizing the individual components of a phase locked loop (PLL) which is used for stable clock generation and synchronization of signals is considered in this work. Verilog-A is used for the high level system design of the main components of the PLL, followed by the individual component wise optimization. The design of experiments (DOE) approach to optimize the analog, 45nm voltage controlled oscillator (VCO) is presented. Also a mixed signal analysis using the analog and digital Verilog behavior of components is studied. Overall a high level system design of a PLL, a systematic optimization of each of its components, and an analog and mixed signal behavioral design approach have been implemented using cadence custom IC design tools.

Susceptibles-infectives-removals (SIR) and its derivatives are the classic mathematical models for the study of infectious diseases in epidemiology. In order to model and simulate epidemics of an infectious disease, a global stochastic field simulation paradigm (GSFS) is proposed, which incorporates geographic and demographic based interactions. The interaction measure between regions is a function of population density and geographical distance, and has been extended to include demographic and migratory constraints. The progression of diseases using GSFS is analyzed, and similar behavior to the SIR model is exhibited by GSFS, using the geographic information systems (GIS) gravity model for interactions. The limitations of the SIR and similar models of homogeneous population with uniform mixing are addressed by the GSFS model. The GSFS model is oriented to heterogeneous population, and can incorporate interactions based on geography, demography, environment and migration patterns. The progression of diseases can be modeled at higher levels of fidelity using the GSFS model, and facilitates optimal deployment of public health resources for prevention, control and surveillance of infectious diseases.

In this dissertation, I start with an analysis of negation in eleven benchmark corpora covering six Natural Language Understanding (NLU) tasks. With a thorough investigation, I first show that (a) these benchmarks contain fewer negations compared to general-purpose English and (b) the few negations they contain are often unimportant. Further, my empirical studies demonstrate that state-of-the-art transformers trained using these corpora obtain substantially worse results with the instances that contain negation, especially if the negations are important. Second, I investigate whether translating negation is also an issue for modern machine translation (MT) systems. My studies find that indeed the presence of negation can significantly impact translation quality, in some cases resulting in reductions of over 60%. In light of these findings, I investigate strategies to better understand the semantics of negation. I start with identifying the focus of negation. I develop a neural model that takes into account the scope of negation, context from neighboring sentences, or both. My best proposed system obtains an accuracy improvement of 7.4% over prior work. Further, I analyze the main error categories of the systems through a detailed error analysis. Next, I explore more practical ways to understand the semantics of negation. I consider …

Modern consumer electronic systems are mostly based on analog and digital circuits and are designed as analog/mixed-signal systems on chip (AMS-SoCs). the integration of analog and digital circuits on the same die makes the system cost effective. in AMS-SoCs, analog and mixed-signal portions have not traditionally received much attention due to their complexity. As the fabrication technology advances, the simulation times for AMS-SoC circuits become more complex and take significant amounts of time. the time allocated for the circuit design and optimization creates a need to reduce the simulation time. the time constraints placed on designers are imposed by the ever-shortening time to market and non-recurrent cost of the chip. This dissertation proposes the use of a novel method, called metamodeling, and intelligent optimization algorithms to reduce the design time. Metamodel-based ultra-fast design flows are proposed and investigated. Metamodel creation is a one time process and relies on fast sampling through accurate parasitic-aware simulations. One of the targets of this dissertation is to minimize the sample size while retaining the accuracy of the model. in order to achieve this goal, different statistical sampling techniques are explored and applied to various AMS-SoC circuits. Also, different metamodel functions are explored for their …

Abstract Probabilistic reasoning under uncertainty suits well to analysis of disease dynamics. The stochastic nature of disease progression is modeled by applying the principles of Bayesian learning. Bayesian learning predicts the disease progression, including prevalence and incidence, for a geographic region and demographic composition. Public health resources, prioritized by the order of risk levels of the population, will efficiently minimize the disease spread and curtail the epidemic at the earliest. A Bayesian network representing the outbreak of influenza and pneumonia in a geographic region is ported to a newer region with different demographic composition. Upon analysis for the newer region, the corresponding prevalence of influenza and pneumonia among the different demographic subgroups is inferred for the newer region. Bayesian reasoning coupled with disease timeline is used to reverse engineer an influenza outbreak for a given geographic and demographic setting. The temporal flow of the epidemic among the different sections of the population is analyzed to identify the corresponding risk levels. In comparison to spread vaccination, prioritizing the limited vaccination resources to the higher risk groups results in relatively lower influenza prevalence. HIV incidence in Texas from 1989-2002 is analyzed using demographic based epidemic curves. Dynamic Bayesian networks are integrated with …

The fight against epidemics/pandemics is one of man versus nature. Technological advances have not only improved existing methods for monitoring and controlling disease outbreaks, but have also provided new means for investigation, such as through modeling and simulation. This dissertation explores the relationship between social structure and disease dynamics. Social structures are modeled as graphs, and outbreaks are simulated based on a well-recognized standard, the susceptible-infectious-removed (SIR) paradigm. Two independent, but related, studies are presented. The first involves measuring the severity of outbreaks as social network parameters are altered. The second study investigates the efficacy of various vaccination policies based on social structure. Three disease-related centrality measures are introduced, contact, transmission, and spread centrality, which are related to previously established centrality measures degree, betweenness, and closeness, respectively. The results of experiments presented in this dissertation indicate that reducing the neighborhood size along with outside-of-neighborhood contacts diminishes the severity of disease outbreaks. Vaccination strategies can effectively reduce these parameters. Additionally, vaccination policies that target individuals with high centrality are generally shown to be slightly more effective than a random vaccination policy. These results combined with past and future studies will assist public health officials in their effort to minimize the effects …

Traditional Public Health decision-support can benefit from the Web and social media revolution. This dissertation presents approaches to mining social media benefiting public health epidemiology. Through discovery and analysis of trends in Influenza related blogs, a correlation to Centers for Disease Control and Prevention (CDC) influenza-like-illness patient reporting at sentinel health-care providers is verified. A second approach considers personal beliefs of vaccination in social media. A vaccine for human papillomavirus (HPV) was approved by the Food and Drug Administration in May 2006. The virus is present in nearly all cervical cancers and implicated in many throat and oral cancers. Results from automatic sentiment classification of HPV vaccination beliefs are presented which will enable more accurate prediction of the vaccine's population-level impact. Two epidemic models are introduced that embody the intimate social networks related to HPV transmission. Ultimately, aggregating these methodologies with epidemic and social network modeling facilitate effective development of strategies for targeted interventions.

People interact with each other through natural language to express feelings, thoughts, intentions, instructions etc. These interactions as a result form relationships. Besides names of relationships like siblings, spouse, friends etc., a number of dimensions (e.g. cooperative vs. competitive, temporary vs. enduring, equal vs. hierarchical etc.) can also be used to capture the underlying properties of interpersonal interactions and relationships. More fine-grained descriptors (e.g. angry, rude, nice, supportive etc.) can also be used to indicate the reasons or social-acts behind the dimension cooperative vs. competitive. The way people interact with others may also tell us about their personal traits, which in turn may be indicative of their probable success in their future. The works presented in the dissertation involve creating corpora with fine-grained descriptors of interactions and relationships. We also described experiments and their results that indicated that the processes of identifying the dimensions can be automated.

In order to run and manage resource-intensive high-performance applications, large-scale computing and storage platforms have been evolving rapidly in various domains in both academia and industry. The energy expenditure consumed to operate and maintain these cloud computing infrastructures is a major factor to influence the overall profit and efficiency for most cloud service providers. Moreover, considering the mitigation of environmental damage from excessive carbon dioxide emission, the amount of power consumed by enterprise-scale data centers should be constrained for protection of the environment.Generally speaking, there exists a trade-off between power consumption and application performance in large-scale computing systems and how to balance these two factors has become an important topic for researchers and engineers in cloud and HPC communities. Therefore, minimizing the power usage while satisfying the Service Level Agreements have become one of the most desirable objectives in cloud computing research and implementation. Since the fundamental feature of the cloud computing platform is hosting workloads with a variety of characteristics in a consolidated and on-demand manner, it is demanding to explore the inherent relationship between power usage and machine configurations. Subsequently, with an understanding of these inherent relationships, researchers are able to develop effective power management policies to optimize …

An early detection of heart disease can save lives, caution individuals and also help to determine the type of treatment to be given to the patients. The first test of diagnosing a heart disease is through auscultation - listening to the heart sounds. The interpretation of heart sounds is subjective and requires a professional skill to identify the abnormalities in these sounds. A medical practitioner uses a stethoscope to perform an initial screening by listening for irregular sounds from the patient's chest. Later, echocardiography and electrocardiography tests are taken for further diagnosis. However, these tests are expensive and require specialized technicians to operate. A simple and economical way is vital for monitoring in homecare or rural hospitals and urban clinics. This dissertation is focused on developing a patient-centered device for initial screening of the heart sounds that is both low cost and can be used by the users on themselves, and later share the readings with the healthcare providers. An innovative mobile health service platform is created for analyzing and classifying heart sounds. Certain properties of heart sounds have to be evaluated to identify the irregularities such as the number of heart beats and gallops, intensity, frequency, and duration. Since …

The increasingly popular cloud-computing paradigm provides on-demand access to computing and storage with the appearance of unlimited resources. Users are given access to a variety of data and software utilities to manage their work. Users rent virtual resources and pay for only what they use. In spite of the many benefits that cloud computing promises, the lack of dependability in shared virtualized infrastructures is a major obstacle for its wider adoption, especially for mission-critical applications. Virtualization and multi-tenancy increase system complexity and dynamicity. They introduce new sources of failure degrading the dependability of cloud computing systems. To assure cloud dependability, in my dissertation research, I develop autonomic failure identification and diagnosis techniques that are crucial for understanding emergent, cloud-wide phenomena and self-managing resource burdens for cloud availability and productivity enhancement. We study the runtime cloud performance data collected from a cloud test-bed and by using traces from production cloud systems. We define cloud signatures including those metrics that are most relevant to failure instances. We exploit profiled cloud performance data in both time and frequency domain to identify anomalous cloud behaviors and leverage cloud metric subspace analysis to automate the diagnosis of observed failures. We implement a prototype of the …

Possession is an asymmetric semantic relation between two entities, where one entity (the possessee) belongs to the other entity (the possessor). Automatically extracting possessions are useful in identifying skills, recommender systems and in natural language understanding. Possessions can be found in different communication modalities including text, images, videos, and audios. In this dissertation, I elaborate on the techniques I used to extract possessions. I begin with extracting possessions at the sentence level including the type and temporal anchors. Then, I extract the duration of possession and co-possessions (if multiple possessors possess the same entity). Next, I extract possessions from an entire Wikipedia article capturing the change of possessors over time. I extract possessions from social media including both text and images. Finally, I also present dense annotations generating possession timelines. I present separate datasets, detailed corpus analysis, and machine learning models for each task described above.

In this dissertation, we have analyzed various security and trustworthy solutions for modern computing systems and proposed a framework that will provide holistic security and trust for the entire lifecycle of a virtualized workload. The framework consists of 3 novel techniques and a set of guidelines. These 3 techniques provide necessary elements for secure and trusted execution environment while the guidelines ensure that the virtualized workload remains in a secure and trusted state throughout its lifecycle. We have successfully implemented and demonstrated that the framework provides security and trust guarantees at the time of launch, any time during the execution, and during an update of the virtualized workload. Given the proliferation of virtualization from cloud servers to embedded systems, techniques presented in this dissertation can be implemented on most computing systems.

This dissertation presents novel approaches to test context aware applications that suffer from a cost prohibitive number of context and GUI events and event combinations. The contributions of this work to test context aware applications under test include: (1) a real-world context events dataset from 82 Android users over a 30-day period, (2) applications of Markov models, Closed Sequential Pattern Mining (CloSPAN), Deep Neural Networks- Long Short Term Memory (LSTM) and Gated Recurrent Units (GRU), and Conditional Random Fields (CRF) applied to predict context patterns, (3) data driven test case generation techniques that insert events at the beginning of each test case in a round-robin manner, iterate through multiple context events at the beginning of each test case in a round-robin manner, and interleave real-world context event sequences and GUI events, and (4) systematically interleaving context with a combinatorial-based approach. The results of our empirical studies indicate (1) CRF outperforms other models thereby predicting context events with F1 score of about 60% for our dataset, (2) the ISFreqOne that iterates over context events at the beginning of each test case in a round-robin manner as well as interleaves real-world context event sequences and GUI events at an interval one achieves …

In this dissertation, we address the problem of vagueness in traditional legal contracts by presenting novel methodologies that aid in the paradigm shift from traditional legal contracts to smart contracts. We discuss key enabling technologies that assist in converting the traditional natural language legal contract, which is full of vague words, phrases, and sentences to the blockchain-based precise smart contract, including metrics evaluation during our conversion experiment. To address the challenge of this contract-transformation process, we propose four novel proof-of-concept approaches that take vagueness and different possible interpretations into significant consideration, where we experiment with popular vendors' existing vague legal contracts. We show through experiments that our proposed methodologies are able to study the degree of vagueness in every interpretation and demonstrate which vendor's translated-smart contract can be more accurate, optimized, and have a lesser degree of vagueness. We also incorporated the method of fuzzy logic inside the blockchain-based smart contract, to successfully model the semantics of linguistic expressions. Our experiments and results show that the smart contract with the higher degrees of truth can be very complex technically but more accurate at the same time. By using fuzzy logic inside a smart contract, it becomes easier to solve the …

With the advent of autonomous systems and deep learning systems, safety pertaining to these systems has become a major concern. The existing failure analysis techniques are not enough to thoroughly analyze the safety in these systems. Moreover, because these systems are created to operate in various conditions, they are susceptible to unknown safety issues. Hence, we need mechanisms which can take into account the complexity of operational design domains, identify safety issues other than failures, and expose unknown safety issues. Moreover, existing safety analysis approaches require a lot of effort and time for analysis and do not consider machine learning (ML) safety. To address these limitations, in this dissertation, we discuss an artificial-intelligence driven model-based methodology that aids in identifying unknown safety issues and analyzing ML safety. Our methodology consists of 4 major tasks: 1) automated model generation, 2) automated analysis of component state transition model specification, 3) undesired states analysis, and 4) causal factor analysis. In our methodology we identify unknown safety issues by finding undesired combinations of components' states and environmental entities' states as well as causes resulting in these undesired combinations. In our methodology, we refer to the behaviors that occur because of undesired combinations as off-nominal …