Article proposes a powerful and computationally efficient gene-based association test, called Overall. Using extended Simes procedure, Overall aggregates information from three types of traditional gene-based association tests and also incorporates expression quantitative trait locus (eQTL) information into a gene-based association test using GWAS summary statistics. The results show that this newly developed method can identify more significant genes than other methods.

In this paper, the authors discuss a novel statistical method for rare-variant association studies in general pedigrees for quantitative traits. This method uses a retrospective view that treats the traits as fixed and the genotypes as random, which accounts for complex and undefined ascertainment of families.

This article demonstrates that whole genome sequencing is an efficient approach for identification of causative genes underlying symbiotic nitrogen fixation defective phenotypes in Medicago truncatula Tnt1 insertion mutants obtained via forward genetic screens.