Recent advancements in machine learning have started to put their mark on educational technology. Technology is evolving fast and, as people adopt it, schools and universities must also keep up (nearly 70% of primary and secondary schools in the UK are now using tablets for various purposes). As these numbers are likely going to follow the same increasing trend, it is imperative for schools to adapt and benefit from the advantages offered by technology: real-time processing of data, availability of different resources through connectivity, efficiency, and many others. To this end, this work contributes to the growth of educational technology by developing several algorithms and models that are meant to ease several tasks for the instructors, engage students in deep discussions and ultimately, increase their learning gains. First, a novel, fine-grained knowledge representation is introduced that splits phrases into their constituent propositions that are both meaningful and minimal. An automated extraction algorithm of the propositions is also introduced. Compared with other fine-grained representations, the extraction model does not require any human labor after it is trained, while the results show considerable improvement over two meaningful baselines. Second, a proposition alignment model is created that relies on even finer-grained units of …

With increasing data and technology, multiple types of data from the same set of nodes have been generated. Since each data modality contains a unique aspect of the underlying mechanisms, multiple datatypes are integrated. In addition to multiple datatypes, networks are important to store information representing associations between entities such as genes of a protein-protein interaction network and authors of a citation network. Recently, some advanced approaches to graph-structured data leverage node associations and features simultaneously, called Graph Neural Network (GNN), but they have limitations for integrative approaches. The overall aim of this dissertation is to integrate multiple data modalities on graph-structured data to infer some context-specific gene regulation and predict outcomes of interest. To this end, first, we introduce a computational tool named CRINET to infer genome-wide competing endogenous RNA (ceRNA) networks. By integrating multiple data properly, we had a better understanding of gene regulatory circuitry addressing important drawbacks pertaining to ceRNA regulation. We tested CRINET on breast cancer data and found that ceRNA interactions and groups were significantly enriched in the cancer-related genes and processes. CRINET-inferred ceRNA groups supported the studies claiming the relation between immunotherapy and cancer. Second, we present SUPREME, a node classification framework, by comprehensively …