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Variation in conserved non-coding sequences on chromosome 5q andsusceptibility to asthma and atopy
Background: Evolutionarily conserved sequences likely havebiological function. Methods: To determine whether variation in conservedsequences in non-coding DNA contributes to risk for human disease, westudied six conserved non-coding elements in the Th2 cytokine cluster onhuman chromosome 5q31 in a large Hutterite pedigree and in samples ofoutbred European American and African American asthma cases and controls.Results: Among six conserved non-coding elements (>100 bp,>70percent identity; human-mouse comparison), we identified one singlenucleotide polymorphism (SNP) in each of two conserved elements and sixSNPs in the flanking regions of three conserved elements. We genotypedour samples for four of these SNPs and an additional three SNPs each inthe IL13 and IL4 genes. While there was only modest evidence forassociation with single SNPs in the Hutterite and European Americansamples (P<0.05), there were highly significant associations inEuropean Americans between asthma and haplotypes comprised of SNPs in theIL4 gene (P<0.001), including a SNP in a conserved non-codingelement. Furthermore, variation in the IL13 gene was strongly associatedwith total IgE (P = 0.00022) and allergic sensitization to mold allergens(P = 0.00076) in the Hutterites, and more modestly associated withsensitization to molds in the European Americans and African Americans (P<0.01). Conclusion: These results indicate that there is overalllittle variation in the conserved non-coding …
Date:
September 10, 2005
Creator:
Donfack, Joseph; Schneider, Daniel H.; Tan, Zheng; Kurz,Thorsten; Dubchak, Inna; Frazer, Kelly A. et al.
Object Type:
Article
System:
The UNT Digital Library
Comment on the Word 'Cooling' as it is Used in Beam Physics
The Institute of Medicine (IOM) of the National Academy of Sciences recently completed a critical review of the scientific literature pertaining to the association of indoor dampness and mold contamination with adverse health effects. In this paper, we report the results of quantitative meta-analysis of the studies reviewed in the IOM report. We developed point estimates and confidence intervals (CIs) to summarize the association of several respiratory and asthma-related health outcomes with the presence of dampness and mold in homes. The odds ratios and confidence intervals from the original studies were transformed to the log scale and random effect models were applied to the log odds ratios and their variance. Models were constructed both accounting for the correlation between multiple results within the studies analyzed and ignoring such potential correlation. Central estimates of ORs for the health outcomes ranged from 1.32 to 2.10, with most central estimates between 1.3 and 1.8. Confidence intervals (95%) excluded unity except in two of 28 instances, and in most cases the lower bound of the CI exceeded 1.2. In general, the two meta-analysis methods produced similar estimates for ORs and CIs. Based on the results of the meta-analyses, building dampness and mold are associated …
Date:
September 10, 2005
Creator:
Sessler, Andrew M.
Object Type:
Article
System:
The UNT Digital Library
Oral History Interview with Billy Tune, July 7, 2005
The National Museum of the Pacific War presents an oral interview with Billy Tune. Tune joined the Navy right after he finished high school in May 1943. He was assigned to USS President Polk (AP-103) and was aboard it when it was torpedoed. He somehow managed to get ashore at Tarawa and stayed with the Marines there for five days. Then he wound up at New Caledonia as a stevedore until he entered the hospital with asthma.
Date:
July 7, 2005
Creator:
Tune, Billy
Object Type:
Text
System:
The Portal to Texas History
Oral History Interview with Billy Tune, July 7, 2005
The National Museum of the Pacific War presents an oral interview with Billy Tune. Tune joined the Navy right after he finished high school in May 1943. He was assigned to USS President Polk (AP-103) and was aboard it when it was torpedoed. He somehow managed to get ashore at Tarawa and stayed with the Marines there for five days. Then he wound up at New Caledonia as a stevedore until he entered the hospital with asthma.
Date:
July 7, 2005
Creator:
Tune, Billy
Object Type:
Sound
System:
The Portal to Texas History
Air Pollution: Estimated Emissions from Two New Mexicali Power Plants Are Low, but Health Impacts Are Unknown
A letter report issued by the Government Accountability Office with an abstract that begins "Power plants emit pollutants that have been linked to various negative health effects. In 2003, two new power plants, owned by Sempra Energy and Intergen, began operations 3 miles south of the U.S.-Mexico border near Imperial County, California. The county does not meet some federal and state air quality standards and may be further impacted by the emissions from these plants. Although these plants export most of the electricity they produce to the United States, they are not currently required to meet any U.S. or California emissions standards. GAO was asked to determine (1) how emissions from the two plants compare with emissions from recently permitted plants in California and emissions from sources in Imperial County, and what emissions standards they would be subject to if they were located in Imperial County; (2) the health impacts of emissions from the plants on Imperial County residents; and (3) options available to U.S. policymakers to ensure that emissions from these plants do not adversely affect the health of Imperial County residents. In commenting on a draft of this report, DOE disagreed with our characterization of the limitations of …
Date:
August 12, 2005
Creator:
United States. Government Accountability Office.
Object Type:
Report
System:
The UNT Digital Library
Environmental Justice Small Grant Awards FY 2005
A list of the environmental justice small grants awarded by the United States Environmental Protection Agency Office of Environmental Justice in fiscal year 2005 (15 pages).
Date:
2005?
Creator:
United States. Environmental Protection Agency. Office of Environmental Justice.
Object Type:
Text
System:
The UNT Digital Library
Securities Fraud: Dura Pharmaceuticals, Inc. v. Broudo
None
Date:
February 1, 2005
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
Securities Fraud: Dura Pharmaceuticals, Inc. v. Broudo
None
Date:
May 11, 2005
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
Surgeon General Releases National Health Advisory on Radon
A report about the dangers and issues with breathing Radon. It describes what Radon is.
Date:
January 13, 2005
Creator:
United States. Department of Health and Human Services.
Object Type:
Report
System:
The UNT Digital Library
The Sealy News (Sealy, Tex.), Vol. 118, No. 58, Ed. 1 Tuesday, July 19, 2005
Semiweekly newspaper from Sealy, Texas that includes local, state, and national news along with advertising.
Date:
July 19, 2005
Creator:
Griffin, Joanie & Ermis, Jay
Object Type:
Newspaper
System:
The Portal to Texas History
The Sealy News (Sealy, Tex.), Vol. 118, No. 92, Ed. 1 Tuesday, November 15, 2005
Semiweekly newspaper from Sealy, Texas that includes local, state, and national news along with advertising.
Date:
November 15, 2005
Creator:
Griffin, Joanie & Ermis, Jay
Object Type:
Newspaper
System:
The Portal to Texas History
Polk County Enterprise (Livingston, Tex.), Vol. 123, No. 64, Ed. 1 Thursday, August 11, 2005
Semi-weekly newspaper from Livingston, Texas that includes local, state and national news along with advertising.
Date:
August 11, 2005
Creator:
White, Barbara
Object Type:
Newspaper
System:
The Portal to Texas History
Polk County Enterprise (Livingston, Tex.), Vol. 123, No. 66, Ed. 1 Thursday, August 18, 2005
Semi-weekly newspaper from Livingston, Texas that includes local, state and national news along with advertising.
Date:
August 18, 2005
Creator:
White, Barbara
Object Type:
Newspaper
System:
The Portal to Texas History
The Albany News (Albany, Tex.), Vol. 129, No. 36, Ed. 1 Thursday, February 3, 2005
Weekly newspaper from Albany, Texas that includes local, county, and state news along with extensive advertising.
Date:
February 3, 2005
Creator:
Lucas, Melinda L.
Object Type:
Newspaper
System:
The Portal to Texas History
Archer County Advocate (Holliday, Tex.), Vol. 3, No. 18, Ed. 1 Thursday, August 11, 2005
Weekly newspaper from Holliday, Texas that includes local, state, and national news along with advertising.
Date:
August 11, 2005
Creator:
McCall, Jody
Object Type:
Newspaper
System:
The Portal to Texas History
Modern Chemistry Techniques Applied to Metal Behavior and Chelation in Medical and Environmental Systems ? Final Report
This report details the research and findings generated over the course of a 3-year research project funded by Lawrence Livermore National Laboratory (LLNL) Laboratory Directed Research and Development (LDRD). Originally tasked with studying beryllium chemistry and chelation for the treatment of Chronic Beryllium Disease and environmental remediation of beryllium-contaminated environments, this work has yielded results in beryllium and uranium solubility and speciation associated with toxicology; specific and effective chelation agents for beryllium, capable of lowering beryllium tissue burden and increasing urinary excretion in mice, and dissolution of beryllium contamination at LLNL Site 300; {sup 9}Be NMR studies previously unstudied at LLNL; secondary ionization mass spec (SIMS) imaging of beryllium in spleen and lung tissue; beryllium interactions with aerogel/GAC material for environmental cleanup. The results show that chelator development using modern chemical techniques such as chemical thermodynamic modeling, was successful in identifying and utilizing tried and tested beryllium chelators for use in medical and environmental scenarios. Additionally, a study of uranium speciation in simulated biological fluids identified uranium species present in urine, gastric juice, pancreatic fluid, airway surface fluid, simulated lung fluid, bile, saliva, plasma, interstitial fluid and intracellular fluid.
Date:
February 3, 2005
Creator:
Sutton, M; Andresen, B; Burastero, S R; Chiarappa-Zucca, M L; Chinn, S C; Coronado, P R et al.
Object Type:
Report
System:
The UNT Digital Library
Assessing Consumer Values and the Supply-Chain Market for the Integrated Water Heater/Dehumidifier
This paper presents a case study of the potential market for the dual-service residential integrated water heater/dehumidifier (WHD). Its principal purpose is to evaluate the extent to which this integrated appliance might penetrate the residential market sector, given current market trends, producer and consumer attributes, and technical parameters. The report's secondary purpose is to gather background information leading to a generic framework for conducting market analyses of technologies. This framework can be used to assess market readiness as well as factor preferred product attributes into the design to drive consumer demand for this product. This study also supports analysis for prototype design. A full market analysis for potential commercialization should be conducted after prototype development. The integrated WHD is essentially a heat-pump water heater (HPWH) with components and controls that allow dedicated dehumidification. Adequate residential humidity control is a growing issue for newly constructed residential homes, which are insulated so well that mechanical ventilation may be necessary to meet fresh air requirements. Leveraging its successful experience with the energy-efficient design improvement for the residential HPWH, the Oak Ridge National Laboratory's (ORNL's) Engineering Science and Technology Division's (ESTD's) Building Equipment Group designed a water-heating appliance that combines HPWH efficiency with dedicated …
Date:
January 11, 2005
Creator:
Ashdown, BG
Object Type:
Report
System:
The UNT Digital Library
The Cuero Record (Cuero, Tex.), Vol. 111, No. 20, Ed. 1 Wednesday, May 18, 2005
Weekly newspaper from Cuero, Texas that includes local, state, and national news along with advertising.
Date:
May 18, 2005
Creator:
Rea, Glenn
Object Type:
Newspaper
System:
The Portal to Texas History
Letter from Concerned Citizens to Commissioner James V. Hansen dtd 10 June 2005
Coalition Correspondence - Letter from Concerned Citizens to Commissioner James V. Hansen regarding Naval Air Station Oceana.
Date:
July 20, 2005
Creator:
unknown
Object Type:
Letter
System:
The UNT Digital Library
Safeguarding the Ozone Layer and the Global Climate System: Issues related to hydrofluorocarbons and perfluorocarbons
This Special Report on Safeguarding the Ozone and the Global Climate System has been developed in response to invitations from Parties to the UNFCCC and the Montreal Protocol. It provides information relevant to decision-making in regard to safeguarding the ozone layer and the global climate system: two global environmental issues involving complex scientific and technical considerations.
Date:
2005
Creator:
Intergovernmental Panel on Climate Change
Object Type:
Book
System:
The UNT Digital Library
The Express-Star (Chickasha, Okla.), Ed. 1 Tuesday, August 16, 2005
Daily newspaper from Chickasha, Oklahoma that includes local, state, and national news along with advertising.
Date:
August 16, 2005
Creator:
Bush, Kent
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Sapulpa Daily Herald (Sapulpa, Okla.), Vol. 91, No. 60, Ed. 1 Wednesday, November 23, 2005
Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.
Date:
November 23, 2005
Creator:
Broaddus, Matthew B.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Albany News (Albany, Tex.), Vol. 129, No. 38, Ed. 1 Thursday, February 17, 2005
Weekly newspaper from Albany, Texas that includes local, county, and state news along with extensive advertising.
Date:
February 17, 2005
Creator:
Lucas, Melinda L.
Object Type:
Newspaper
System:
The Portal to Texas History
Today Cedar Hill (Duncanville, Tex.), Vol. 40, No. 19, Ed. 1 Thursday, August 25, 2005
Weekly newspaper published in Duncanville, Texas that includes local Cedar Hill, state, and national news along with advertising.
Date:
August 25, 2005
Creator:
Gooch, Robin
Object Type:
Newspaper
System:
The Portal to Texas History