This paper describes biological contributing factors to substance abuse and addiction. The second document being produced by this study will discuss the complex interactions of biochemical, physiological, psychological, and sociological factors leading to substance abuse and addiction.

The report reviews data concerning the contribution of genetic factors to several severe mental disorders; described methodologies used in the studies, and broached several policy issues relevant to this area of research.

This short background paper summarizes the discussion concerning data pricing and distribution from a one-day workshop convened by OTA on May 20, 1992.

This paper assesses the medical benefits and costs of both screening and hormone replacement therapy. It is divided into two volumes. This volume provides the basis for the assumptions about the costs and effects of screening and hormonal replacement therapy used in the cost-effectiveness model.

This paper assesses the medical benefits and costs of both screening and hormone replacement therapy. It is divided into two volumes. This volume presents the results of a model that estimates the cost per year of life gained from osteoporosis screening and hormone replacement therapy in postmenopausal women.

This background paper focuses on the Federal role in supporting a national high-performance computing initiative. High-performance ‘‘supercomputers’ * are fast becoming tools of international competition and they play an important role in such areas as scientific research, weather forecasting, and popular entertainment. They may prove to be the key to maintaining America’s preeminence in science and engineering. The automotive, aerospace, electronic, and pharmaceutical industries are becoming more reliant on the use of high-performance computers in the analysis, engineering, design, and manufacture of high-technology products.

The report focuses on mental disabilities, a broad rubric. In this background paper, OTA examines current knowledge about psychiatric disabilities and employment in the context of the ADA’s requirements and reviews Federal activities directly or indirectly aimed at supporting the ADA’s employment provisions.

This background paper is one of four documents resulting from OTA’s study of policy issues in the prevention and treatment of osteoporosis.

This background paper describes what is known about the natural progression of the menopause and its effect on women’s health, hormone treatment and prescribing practices, alternative approaches, and research needs.

This background paper, which describes the state-of the- art of identifying substances that can harm the immune system, represents one response to the committee’s request. Chapter 2 provides basic information about the principal components of the immune system and the general consequences that stem from perturbations to it. Chapter 3 describes methods for evaluating chemical immunotoxicity and reports on some known or suspected immunotoxicants. Chapter 4 summarizes Federal research and regulatory activities related to immunotoxicity.

This Background Paper examines whether the agencies responsible for administering Federal environmental and health and safety laws have taken this concern for respiratory health to heart. This paper provides a partial response to the committees’ request for an assessment of noncancer health risks in the environment and follows OTA’s previous work on carcinogenic, neurotoxic, and immunotoxic substances.

This paper presents results from a 1991 OTA survey of 431 genetic counselors and nurse geneticists. It was conducted to better understand the environment in which the average genetic counselor or nurse in genetics works, to describe the infrastructure and tools available to these professionals, to assess the state of practice in the provision of cystic fibrosis (CF) carrier screening, and to evaluate their attitudes regarding CF carrier screening.

This background paper reviews and evaluates the available literature linking health insurance coverage with the utilization and process of health care services and with individual health outcomes.

This background paper describes what appears to be an enlarging potential for conflict between the two, as reflected in disputes about the trade impacts of environmental laws and about the environmental impacts arising from efforts to liberalize trade and investment. The paper explores some trade and environment questions, especially from the context of the General Agreement on Tariffs and Trade, which provides a framework of rules governing most of the world’s trade.

A report on High Definition Television (HDTV. During 1989, HDTV moved from obscurity to center stage in the ongoing debate over the role of the Federal Government in U.S. industrial competitiveness. HDTV and related High-Resolution System (HRS) technologies in the computer and communications sectors may significantly impact U.S. electronics manufacturing, accelerate fundamental restructuring of the U.S. communications infrastructure, and provide a host of valuable services.