Applications of radioisotopes in the preparation of labeled drugs are reviewed. Among the applications described are the preparation of carbon-14- labeled cardiac glycosides, and the biosyinthesis of carbon-14-labeled digitoxin, morphine, colchicine, atropine, podophyllotoxin, and nicotine. The fate and metabolism of many of these drugs were traced. Radiochemical procedures were developed for the synthesis of pure compounds of pharmacological interest labeled with carbon-14, sulfur-35, and tritium. Investigations were made on the phenomena of drug penetration into the central nervous system. Publications during the period are listed. (C.H.)

From Introduction: "Results are presented to indicate the effect of altitude, flight Mach number, and exhaust-nozzle-outlet area on the combustion efficiency, the losses in total pressure occurring in the combustion chamber, and the fractional loss in engine cycle efficiency resulting from combustion-chamber pressure losses. The engine cycle efficiency is also presented.These results are shown graphically as a fraction of corrected engine speed and in tabular form."

From Summary: "From a theory developed on a quasi-one-dimensional-flow basis, it was found that the stability of the ram jet is dependent upon the instantaneous values of mass flow and total pressure recovery of the supersonic diffuser and immediate neighboring subsonic diffuser. Conditions for stable and unstable flow were presented. The theory developed in the report was in agreement with the experimental data of the reports both of Sterbentz and Evvard and of Ferri and Nucci."

Report issued by the Brookhaven National Laboratory discussing the area survey manual covering the 15 service stations. Design and operations of the service stations are presented. This report includes tables, illustrations, photographs, and a map.

This is an assessment report on the population of marine mammals along the U.S. Pacific coastline. These reports are ever-growing and subject to change annually.