This thesis examines how drug policy and enforcement affect drug manufacturers. The approach taken is a comparative institutional analysis of cannabis and methamphetamine production. I focus on the effects of prohibition, privacy, and clandestine markets on producer behavior for these two drugs and the unintended consequences that result. I demonstrate that cannabis and methamphetamine producers both face substantial transaction costs and that producers alter their behavior to manage these transaction costs. I conclude that cannabis producers can adopt indoor, small-scale operations to hide their activity, which are capable of yielding continuous, high-potency crops. Methamphetamine producers also adopt small-scale, decentralized strategies, but commodity control increases their exposure and leads to greater overall transaction costs during the manufacturing process.