Applications of radioisotopes in the preparation of labeled drugs are reviewed. Among the applications described are the preparation of carbon-14- labeled cardiac glycosides, and the biosyinthesis of carbon-14-labeled digitoxin, morphine, colchicine, atropine, podophyllotoxin, and nicotine. The fate and metabolism of many of these drugs were traced. Radiochemical procedures were developed for the synthesis of pure compounds of pharmacological interest labeled with carbon-14, sulfur-35, and tritium. Investigations were made on the phenomena of drug penetration into the central nervous system. Publications during the period are listed. (C.H.)

Irradiation of a living animal with X-rays induces alternation in the proteins of cells in which ionization events occur. Systematic end-products such as the proteins of plasma would, by changes in quality and quantity divulge modification of their synthetic pathways, or compensatory responses of the hematopoietic systems to stresses caused by irradiation in other organs. Serological identification of proteins, a sensitive means of biochemical characterizations was chosen to reveal variations in the proteins of the plasmas of chickens that had been exposed to large, but sub-lethal, doses of X-ray irradiation. Turbidimetric comparisons were made of precipitation tests involving reactions between antisera produced in rabbits against the sera of normal chickens, and pre-irradiation and post-irradiation samples of plasma from 15 chickens.

Work was completed on the high-temperature, high efficiency air filter. Technical assistance was given at a large-scale, privately financed run of an all-glass medium. Full-size filers have been produced in quantity and are offered by manufacturers; it is considered that commercial manufacture has been established. A survey was made of air sampling practices at 37 laboratories. Analysis of the survey results indicated that 22 different kinds of air-sampling filer media were in use among the laboratories questioned. We have recommended that air-assay practice be simplified by use of fewer media. A group of five media has been proposed as adequate for meeting all requirements. Laboratory work was done on the development of a high-efficiency, low-ash, all-purpose, air-assay paper. Two methods of approach were tried. In one an effort was made to produce cellulose fibrils in sufficient quantity and quality to act as the fine-fiber component of a filter. Only moderate success was attained. Better promise was shown by combining synthetic organic microfibers with cellulose fibers in a wet-formed sheet. No plant work was undertaken on this item.

"Dust and gas masks and respirators have been an effective method under certain environmental conditions to reduce the inhalation of toxic aerosols. Under many conditions, however, their efficacy has been seriously questioned. It is the purpose of this study to evaluation over-all respirator performance on fine aerosols and to develop equipment whereby a greater degree of respiratory protection may be assured with reliability for highly toxic atmospheres."

References to 193 publications of staff members of the Atomic Bomb Casualty Commission during 1947 through 1959 are listed in both English and Japanese. Author and subject indexes are included.

Field evaluations made of uranium deposits located in and near southwestern Turkey

Report on ecological investigations sponsored by U.S. Atomic Energy Commission.

Abstract: Progress is reported on research and development tasks under the Program Plan for Engineering Support and Development of Army Pressurized Water Reactor Power Plants, Contract AT(30-1)-2639, during the six months' period October 1, 1061 to March 31, 1962.

Final report documenting a high-sensitivity airborne radiometric and magnetic survey of the Newark quadrangles including the survey description, specifications, data processing methods, interpretation methods, and regional geologic review.

Final report documenting a high-sensitivity airborne radiometric and magnetic survey of the Scranton quadrangles including the survey description, specifications, data processing methods, interpretation methods, and regional geologic review.

A report about investigations of several binary alloy systems of thorium. Some of these alloys containing lead, molybdenum and tin have been prepared in the tungsten arc furnace.

From abstract: This two-part report provides an essentially complete listing of radioactive occurrences in Colorado, with a comprehensive bibliography and bibliographic cross-indexes.

A survey and analysis of the potential opportunity for the use of nuclear reactors to satisfy process and space heat requirements in the continental United States and Alaska has been completed. The greatest emphasis has been devoted to manufacturing industries that utilize large quantities of process heat.

From introduction: This study considered the region comprising the Upper Mississippi and Lower Missouri River basins and to assess the contributions to the radiation potentially received by the populace from airborne radionuclides originating in adjacent areas, an "air envelope" zone, some 200 miles wide.

From introduction: Preliminary assessment between the United States, Mexico, and the IAEA on the technical and economic practicability of a dual-purpose nuclear power plant designed to produce fresh water and electricity for the southern border portion of the Colorado River.

From preface: Proceedings of a conference of AEC contractor and depository librarians on the operations of the Division of Technical Information

From introduction: This report is a summary of the lecture material in the training course held at Idaho Falls, Idaho, to familiarize members of radiological assistance teams with information helpful in the response to an unusual accident including release of radioactive materials to a populated environment.

From introduction: This report is a summary of the lecture material in the training course held at Idaho Falls, Idaho, to familiarize members of radiological assistance teams with information helpful in the response to an unusual accident including release of radioactive materials to a populated environment.

Introduction: Atomic Energy Facts is designed to serve as an introduction to nuclear operations in the United States and as a handbook of related information for the use of industrial firms and other active or interested in atomic energy.

Abstract: A 12,000 curie cesium-137 research irradiator has been designed and installed on the Georgia Tech campus. The evaluation of the physical characteristics of the irradiator has been completed.

From introduction: This report is a survey of the composition and abundance of the various species of fish present. Other features to be noted are the rate of growth and the condition of the individual fish as indicated by the relationship between the length and weight. In addition, observations on the success of reproduction, the ability of any species to maintain itself as an integral part of the population and food supply.

Introduction: The primary objective of the work of this report was research and development leading to large-scale applications of low level isotope tracer technology.

From foreword: "This report is a comprehensive overview study of potential alternative methods for long-term management of high-level radioactive waste...Disposal in terrestrial locations."

From foreword: "This report is a comprehensive overview study of potential alternative methods for long-term management of high-level radioactive waste."