Frizella C. Whitiker was born in Greenwood, Lousiana and grew up in Austin, Texas. Whitiker graduated from Anderson High School and Samuel Huston University (1950), now Huston-Tillotson University, in Austin. Upon graduation, Whitiker moved to Odessa to teach in the Ector County Independent School District, specifically Blackshear High School. She retired from teaching in 1986. In Odessa, Whitiker has been a sponsor and board member of Head Start as well as a board member of the Black Cultural Council of Odessa. She has also been a leader of Mackey Chapel of the United Methodist Church.