This document is the February 1969 monthly report for Hanford Categories C-57 and C-65. It contains information on reactor plant operation, fuel and target fabrication, technical activities, and irradiation services for the Hanford Production and Irradiation reactors. The document features a discussion of the backup coolant supply systems for the B and C reactors.

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Separate abstracts have been prepared on 10 papers covering research carried out or completed during the period. A list is included of staff publications. (For preceding period see ACRH-12.) (C.H.)

Progress in radiobiology and caneer research is reported. Topics covered include: comparison of the effects of isologous, homologous, and heterologous hematopoietic tissues on post-irradiation survival; survival of transfused blood in rats; erythropoietic response to erythropoietin; inhibition of erythropoiesis by estrogens; tryptophan metabolism; effect of daily exposure to l5-r gamma radiation on susceptibility of mice to experinrental infection; restorailon of serum bactericidal activity and prevention of its loss in x- irradiated mice; immunohistochemical study of Ehrlich ascites tumor; comparison of effects of I/sup 131/-induced hypothyroidism and L-triiodothyronine on irradiated hair roots in mice; modification of radiation responses of tissue by colchicine; production and use of I/sup 131/; localization of ocl evaluation of brain scanning system; thick target yield and excitation function for the reaction Rh/sup 103/(p,n)Pb/sup 103/; incorporation of C/sup 14/ and tritium precursors into brain; net synthesis of RNA with a microleial enzyme requiring DNA and four ribonueleoside triphosphates; snythesis of (P/sup 37/) uridine 5'- phosphate; and of 17- alpha -hydroxyprogesterone-4-C/sup 14/-l7 alpha -caproate by homogenates of rat liver and human placenta. (M.C.G.)

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The objective of the meeting was to provide a companion meeting to the ''First Symposium on Accelerator Radiation Dosimetry and Experience'' which was held November 3-5, 1965, at the Brookhaven National Laboratory. This first symposium was limited in scope to an intensified discussion of dosimetry techniques. The biology which is associated with high energy radiation was specifically excluded, since it was the original plan to hold a second symposium devoted entirely to biology. Thus the present Symposium was a sequel to the first and they were inseparable in their objectives. Since those attending the BNL Symposium were almost entirely health physicists with a background in physical science and actively engaged in the solution of radiation protection problems at high energy accelerators, it was felt that it would be necessary to begin the BID Symposium with a general review session on radiation biology, in order to provide a biological background for the proper understanding of the later sessions. This first session was arranged to give the health physicist a meaningful transition from fundamental radiobiological considerations to current new research activities in high energy biology. In our opinion, and also based on the comments of several of those attending these objectives were …