The problem of this study was to determine whether or not the variables locus of control, perceived anxiety, anxiety proneness, nursing experience and intensive care experience were better than chance predictors of job stress in intensive care nurses. The study was conducted using 200 volunteer nurses (RN's) who worked in the Intensive Care Units of two major hospitals in a large metropolitan area. All subjects were administered Spielberger's State-Trait Anxiety Inventory, Rotter Internal-External Locus of Control Scale and the Nursing Stress Scale as well as a demographic questionnaire. Multiple Regression Analysis was used to determine the predictive value of the characteristic variables to job stress and to determine the most efficient predictive model possible using these variables.