An Employee Participation Change Project and Its Impact on the Organization: a Case Study (open access)

An Employee Participation Change Project and Its Impact on the Organization: a Case Study

The purpose of this study was to document and assess the consequences of implementing employee involvement in a manufacturing setting. Using a quasi-experimental design, the study utilized information from various sources of data including archives, interview, and questionnaire data for a three to four year period. Time series comparisons were used. The results indicated that production increased initially, but then dropped back to original level. Quality of products increased and continued to improve gradually. The highest rate of improvement was observed in safety. An attempt was made to measure current level of commitment at the plant but was unsuccessful due to a low return rate of questionnaires. Overall, data collected partially support the hypotheses. Implications for further research and practice are discussed.
Date: August 1990
Creator: Roustaei, Simin
System: The UNT Digital Library
Neuropsychological Functioning in Non-Schizophrenic First-Degree Relatives of Schizophrenics (open access)

Neuropsychological Functioning in Non-Schizophrenic First-Degree Relatives of Schizophrenics

Research has consistently shown schizophrenics to perform significantly poorer than normal controls on commonly used measures of neuropsychological functioning. Research on the neuropsychological functioning of first-degree relatives of schizophrenics who do not themselves have schizophrenia is comparatively sparse but suggests the likelihood of deficits in this group as well. A battery of standard neuropsychological tests was administered to three groups: first-degree relatives of schizophrenics who do not themselves have schizophrenia (FDR-SCZ), first-degree relatives of persons with major depression and bipolar disorder (FDR-MOOD), and normal controls (NC). The FDRSCZ group was not found to demonstrate significantly impaired performance relative to the other two groups on any of the hypothesized or exploratory analyses. These implications of these findings are discussed with reference to previous studies and future research.
Date: August 1998
Creator: Suire, David M. (David Mark)
System: The UNT Digital Library
Evaluation of the Quick Inventory of Depressive Symptomatology - Self-Report (QIDS-SR) in a spinal cord injury population. (open access)

Evaluation of the Quick Inventory of Depressive Symptomatology - Self-Report (QIDS-SR) in a spinal cord injury population.

Spinal cord injury (SCI) is an acute and devastating event that results in significant and permanent life changes for the individuals who are injured, as well as their families and friends. Depression has received more attention from clinicians and researchers than any other psychological issue among persons with SCI. Measurement of depression in this population has a variety of methodological issues, including inconsistent assessments used (self-report versus clinical interviews), varying definitions of depression, inclusion and exclusion of physical symptoms in the assessment process, and use of measures that do not represent DSM-IV criteria for major depressive disorder. The primary goal of this study was to evaluate the Quick Inventory of Depressive Symptomatology - Self-Report (QIDS-SR) and provide descriptive analyses of this measure with persons with SCI. Results showed that somatic symptoms were more frequently endorsed than psychological symptoms in this population. Additionally, scores on the QIDS-SR were significantly associated with a depression diagnosis in the patient's medical chart. However, QIDS-SR scores were not found to be correlated inversely with quality of life scores as predicted. The QIDS-SR was shown to have good internal consistency and convergent validity with patients with SCI. However, it failed to demonstrate construct validity. The QIDS-SR …
Date: August 2008
Creator: Reed, Kristin
System: The UNT Digital Library
Correlates and Predictors of Medication Noncompliance in Patients with Schizophrenia (open access)

Correlates and Predictors of Medication Noncompliance in Patients with Schizophrenia

The treatment of schizophrenia today consists of a multi-component system of services. Mental health professionals generally agree that anti-psychotic medications are an essential treatment for schizophrenia. However, adherence to medication regimens by patients with schizophrenia is notoriously poor. To identify correlates and predictors of medication compliance, the Schedule for Affective Disorders and Schizophrenia (SADS), a semi-structured diagnostic interview, was administered to 90 outpatients with schizophrenia. The results suggest that there are specific variables (i.e., mood symptoms, psychotic symptoms, and socio-demographic variables) that predict medication compliance. In addition, the confirmation of these variables was effective (90.0%) at identifying non-compliant patients. The results suggest that schizophrenia is a complex disorder composed of heterogeneous symptoms. However, a specific group of symptoms is proposed which may provide a screening measure for predicting patients who are likely to be non-compliant with their medications.
Date: August 1995
Creator: Duncan, Julianne Christine
System: The UNT Digital Library
Psychological characteristics contributing to performance on neuropsychological tests and effort testing. (open access)

Psychological characteristics contributing to performance on neuropsychological tests and effort testing.

The issue of effortful patient performance has been an area of clinical interest in individuals with minor traumatic brain injury (mTBI). Clinical attention to this area has increased largely because of an increase in the number of worker's compensation claims, injury-related lawsuits and/or insanity defense pleas. As patients are presented with the opportunity for secondary gain, the issue of optimum performance on neuropsychological measures becomes salient. In addition to neurocognitive deficits, there are psychological characteristics associated with mTBI including depression, emotional disturbance, personality changes, and other psychopathology. This study utilized the MSVT, a set of standard neuropsychological instruments, and the Minnesota Multiphasic Inventory-2 (MMPI-2) to investigate the relationships between effort, psychological characteristics, and neuropsychological functioning in individuals with minor traumatic brain injuries. The first objective of this study was to determine which psychological factors were related to effort in mTBI. The second objective was to determine if there were differences between groups that performed poorly on effort testing and groups that performed adequately on effort testing, based on relevant psychological characteristics. The results of the analyses supported the first hypothesis. Hysteria was inversely related to effort, and Mania was positively related to effort on one of five measures of effort. …
Date: August 2008
Creator: Hilborn, Robert Scott
System: The UNT Digital Library
Seasonality of Birth in Schizophrenia in Taiwan (open access)

Seasonality of Birth in Schizophrenia in Taiwan

The phenomenon of seasonality of birth in schizophrenia is important in the study of the etiology of this mental disorder because it helps to give directions for further research. Patients' hospital files from 1981 to 1991 of two of the largest hospitals with psychiatric wards in Taiwan were reviewed, and dates of birth collected on 3346 patients diagnosed with schizophrenia. After adjusting for the variations of the total monthly births in the population, an Auto-Regressive Integrated Moving Average (ARIMA) model was applied. Results support a seasonality phenomenon and indicate a disproportional excess of births in schizophrenia in the cold months (Nov. to Feb.) compared to the hot months (May to Aug.). These findings are compatible with many other studies in other countries and climates. Further investigations of season-related environmental factors in the etiology of schizophrenia are recommended.
Date: August 1993
Creator: Tam, Wai-Cheong Carl
System: The UNT Digital Library
Prediction of Hearing Thresholds by Means of the Acoustic Reflex with Autistic and Normal Subjects (open access)

Prediction of Hearing Thresholds by Means of the Acoustic Reflex with Autistic and Normal Subjects

This study concerns audiometric evaluation and prediction of hearing loss in the autistic child based on information derived from acoustic reflex thresholds. Two groups (autistic males and normal children) of five subjects each were utilized. Results indicated that the acoustic reflex method consistently predicted significantly higher hearing thresholds for autistic subjects than operant pure-tone audiometric procedures. Furthermore, the acoustic reflex thresholds were significantly less sensitive in the autistic group than in the normal group, suggesting that the acoustic reflex response is somehow altered in autistic individuals. These findings are consistent with earlier work which hypothesized that autistics, manifest an organic brain lesion which interferes with the propagation of auditory information.
Date: August 1979
Creator: Hutchison, Edward N.
System: The UNT Digital Library
The Nature of Cognitive Impairment in Multiple Sclerosis (open access)

The Nature of Cognitive Impairment in Multiple Sclerosis

Cognitive impairment is common in multiple sclerosis (MS), with as many as 70% of patients with MS affected. Individuals with MS who experience cognitive deficits are less likely to be employed, and may have more difficulty performing independent activities of daily living. Most commonly, deficits are observed in processing speed, complex attention, and memory. Because lesion location varies widely among individuals, no clear pattern of cognitive dysfunction in MS has emerged. However, a number of risk and protective factors may influence the likelihood of individuals to develop and/or express dysfunction, though the contribution of each to specific domains of cognition has not been fully explored. Recently, support for the cognitive reserve hypothesis (i.e., enriching life experiences protect against cognitive decline despite disease burden) has emerged in the MS literature. The current study investigated the contributions of cognitive reserve to learning and memory functioning in MS and the interaction of cognitive reserve variables and risk factors known to impact cognitive functioning in individuals with MS. Finding revealed cognitive reserve protects against decline in the domains of processing speed and complex attention. Furthermore, indirect protective effects of cognitive reserve through these domains were observed for verbal learning and memory. Finally, in line …
Date: August 2018
Creator: Carlew, Anne R.
System: The UNT Digital Library
Internalizing-externalizing Psychopathology and Personality Pathology As Predictors of Treatment Rejection in Substance Users (open access)

Internalizing-externalizing Psychopathology and Personality Pathology As Predictors of Treatment Rejection in Substance Users

Substance use disorders (SUDs) are often comorbid with other psychopathology such as mood disorders, anxiety disorders, and personality disorders. While some research suggests individuals with comorbid psychopathology are more likely to seek substance use treatment than those with independent disorders, other studies have also shown many individuals with dual diagnoses still never seek treatment. Moreover, few studies have tried to elucidate the underlying structure of SUD treatment rejection, and instead examined it in more simplistic terms. In addition, studies have tended to examine the impact of individual disorders on treatment rejection, but have not incorporated an empirically supported approach to conceptualizing psychopathology in terms of comorbidity between broad latent dimensions referred to as internalizing (e.g., depression, anxiety) and externalizing (e.g., antisocial personality disorder, polysubstance use) psychopathology. Modeling psychopathology in terms of internalizing and externalizing psychopathology is becoming a prominent approach to understanding mental disorders, yet little research to date has investigated the effects these broad dimensions have on SUD treatment rejection. The current study utilized latent variable modeling techniques to (1) determine the latent structure of SUD treatment rejection in a large U.S. sample, and investigate whether treatment rejection is a multidimensional construct; and (2), to explore the ability of …
Date: August 2013
Creator: Lewis, Jonathan James
System: The UNT Digital Library

Assessment of Feigned Neurocognitive Impairment in Retired Athletes in a Monetarily Incentivized Forensic Setting

Compromised validity of test data due to exaggeration or fabrication of cognitive deficits inhibits the capacity to establish appropriate conclusions and recommendations in neuropsychological examinations. Detection of feigned neurocognitive impairment presents a formidable challenge, particularly for evaluations involving possibilities of significant secondary gain. Among specific populations examined in this domain, litigating mild traumatic brain injury (mTBI) samples are among the most researched. One subpopulation with potential to contribute significantly to this body of literature is that of retired athletes undergoing fixed-battery neuropsychological evaluations within an assessment program. Given the considerable prevalence of concussions sustained by athletes in this sport and the substantial monetary incentives within this program, a unique opportunity exists to establish rates of feigning within this population to be compared to similar forensic mTBI samples. Further, a fixed battery with multiple validity tests (VT) offers a chance to evaluate the classification accuracy of an aggregated VT failure paradigm, as uncertainty abounds regarding the optimal approach to the recommended use of multiple VTs for effort assessment. The current study seeks to examine rates of feigned neurocognitive impairment in this population, demonstrate prediction accuracy equivalence between models based on aggregated VT failures and logistic regression, and compare classification performance of …
Date: August 2020
Creator: Smotherman, Jesse M.
System: The UNT Digital Library
Information Processing in Schizophrenia and Bipolar Disorder: A Discriminant Analysis Study (open access)

Information Processing in Schizophrenia and Bipolar Disorder: A Discriminant Analysis Study

A study was conducted in which a computerized battery of information processing tasks (called the COGLAB) was administered to three subject groups: patients with schizophrenia, patients with bipolar disorder, and normal controls. The tasks included Mueller-Lyer illusion, reaction time, size estimation, Wisconsin Card Sort, backward masking. and Asarnow Continuous Performance.
Date: August 1995
Creator: Tam, Wai-Cheong Carl
System: The UNT Digital Library
Performance of Adults With and Without Attention-Deficit/Hyperactivity Disorder (ADHD) on Measures of Response Inhibition and Frontal Lobe Functioning (open access)

Performance of Adults With and Without Attention-Deficit/Hyperactivity Disorder (ADHD) on Measures of Response Inhibition and Frontal Lobe Functioning

In this study 2 groups of adults, those with and without ADHD, were studied in terms of cognitive functioning and symptoms of ADHD, depression, anxiety, and substance abuse. Due to the difficulties in diagnosing ADHD in this population three methods of diagnosis were used and the resulting findings presented. The groups did not differ in measures of depression, anxiety, substance abuse or age. Those adults who met criteria for ADHD showed worse performance on a measure of response inhibition compared to those without ADHD. The patterns of correlations among the cognitive measures differed between the two groups. The conclusions from the findings are discussed in relation to Barkley's (1997) self-regulation model of ADHD.
Date: August 2000
Creator: Wodushek, Thomas R.
System: The UNT Digital Library
Performance of Psychiatric and Head Injury Patients on the General Neuropsychological Deficit Scales (open access)

Performance of Psychiatric and Head Injury Patients on the General Neuropsychological Deficit Scales

Reitan and Wolfson's General Neuropsychological Deficit Scale and Left and Right Neuropsychological Deficit Scales were applied to Halstead-Reitan test data of individuals with psychotic or substance abuse disorders with and without a head injury.
Date: August 1997
Creator: Collingwood, Lisa M. (Lisa Marie)
System: The UNT Digital Library
Feigning ADHD: Effectiveness of Selected Assessment Tools in Distinguishing Genuine from Simulated ADHD (open access)

Feigning ADHD: Effectiveness of Selected Assessment Tools in Distinguishing Genuine from Simulated ADHD

Research indicates that some college students may be strongly motivated to feign AHDD symptoms for desired external incentives, such as stimulant medication or academic accommodations. To date, literature examining feigned ADHD has been primarily focused on ADHD specific self-report measures (e.g., CAARS) and continuous performance tests (e.g., CPTs); however, little attention has been devoted to the use of multi-scale inventories in detecting feigned ADHD. For CPT measures, virtually no literature exists on the effectiveness of the TOVA to identify feigned ADHD, despite its frequent clinical use for establishing this diagnosis. The current study utilized a between-subjects simulation design to validate feigning cut scores on ADHD-specific measures using 66 feigners and 51 confirmed ADHD cases. As prior literature suggested, the results convincingly demonstrated that face-valid ADHD assessment measures were easily faked. Across both TOVA modalities (e.g., Auditory and Visual), the ADHD simulators performed significantly poorer than those diagnosed with ADHD. As an innovative approach, a Dissimulation-ADHD (Ds-ADHD) scale was developed and initially validated. The Ds-ADHD is composed of ten MMPI-2-RF items mistakenly believed to be clinical characteristics associated with ADHD. Requiring cross-validation, Ds-ADHD optimized cut scores and classification of ADHD feigners appears promising. They were clearly distinguishable from ADHD client, as …
Date: August 2016
Creator: Robinson, Emily
System: The UNT Digital Library

Bipolar Spectrum Traits in Day-to-Day Life: Ecological Momentary Assessment of Reward Sensitivity, Circadian Timing, and Experience of Reward in the Environment

Access: Use of this item is restricted to the UNT Community
The current study examined 236 undergraduate students in a week long twice-per-day ecological momentary assessment exploring the influence of baseline reward sensitivity and interactions between circadian variables (i.e., total sleep time, sleep quality) and daily measures of reward. Though primary study findings did not support reward sensitivity related moderation of sleep-reward pathways, a number of notable findings emerged. We found evidence of specific domains of reward sensitivity (anticipatory reward and reward responsiveness) which are uniquely related to daily experiences of reward. In addition, bidirectional circadian-reward pathways were found between sleep quality and daily rewards which suggests pathways towards reward-related engagement. Evidence also supported interactions between sleep quality and total sleep time on experience of daily reward, further highlighting the complexity of sleep-reward pathways and their relevance to mood symptoms.
Date: August 2019
Creator: Smith, Patrick M.
System: The UNT Digital Library
Hormones, Distress, and Immune Functioning in Women (open access)

Hormones, Distress, and Immune Functioning in Women

The present study set out to investigate the biopsychosocial model of illness using variables previously identified as directly impacting illness or as mediating the relationship between other variables and illness. Oral contraceptive use, stress, and negative affect were investigated as predictors of immunological competence, measured by the level of Immunoglobulin G antibodies to Epstein-Barr Virus Viral Capsid Antigen (EBV-VCA IgG).
Date: August 1998
Creator: Rubino-Watkins, Maria Francesca
System: The UNT Digital Library
The utility of the McCarron-Dial System in determining location of brain lesion. (open access)

The utility of the McCarron-Dial System in determining location of brain lesion.

Among the goals of neuropsychological assessment are to detect the presence of brain damage, localize which areas of the brain may be dysfunctional, and describe subsequent functional impairments. The sensitivity of neuropsychological instruments in carrying out these functions has long been a question of debate. The purpose of the present study was to determine the utility of various performance level indictors and lateralizing indicators from the McCarron-Dial System Neuropsychological Assessment Battery (MDS) in ascertaining the presence or absence of brain damage as well as location of lesion. Models used in the present study appear to provide increased classification accuracy compared to other studies utilizing the MDS. The MDS was also shown to be comparable to other well-known neuropsychological batteries, including the Halstead-Reitan Neuropsychological Test Battery (HRB) and the Luria-Nebraska Neuropsychological Battery (LNNB) with regard to distinguishing between those with brain damage and normal controls, and also localizing brain lesion. The results of this study offer clinicians parsimonious models to evaluate for presence of lesion and its location so this information may be used to make accurate, thorough diagnoses and appropriate treatment and rehabilitation recommendations.
Date: August 2004
Creator: Taylor, Erin Kathleen
System: The UNT Digital Library
MMPI-2 Patterns of Adults with Attention-Deficit Hyperactivity Disorder (open access)

MMPI-2 Patterns of Adults with Attention-Deficit Hyperactivity Disorder

Recent literature suggests that not only does Attention-deficit Hyperactivity Disorder (ADHD/ADD) persist into adulthood, but it can also be accompanied by personality characteristics which cause emotional difficulties. In fact, adults diagnosed with ADHD can present with a profusion of difficulties. Several constructs appear to accumulate dynamically throughout development to place the adult with ADHD at risk for multiple emotional problems. These interwoven influences include familial characteristics, childhood emotional and academic difficulties, and inadequate coping skills to respond to adulthood pressures. This document, first, describes a developmental model for conceptualizing negative trajectories leading to nonadaptive coping and psychopathology and identifies personality factors of adults diagnosed with ADHD. This model provides clinicians and researchers with a better understanding of the complexity and challenges of adulthood ADHD in order to aid in diagnosis, treatment, and prevention. The purpose of this study is to examine personality factors common to adults diagnosed with ADHD and compares these characteristics with a group of adults diagnosed with a depressive disorder. Adults responding to a community advertisement who provided documentation of the diagnosis of Attention-deficit Hyperactivity Disorder were administered the MMPI-2. This ADHD group was compared with MMPI-2 profiles of a group of adults diagnosed with Major Depressive …
Date: August 1998
Creator: Campbell, Catherine Elaine
System: The UNT Digital Library
Physical Activity and Relationship Functioning: Mediation Roles of Sexual Satisfaction and Self-Esteem (open access)

Physical Activity and Relationship Functioning: Mediation Roles of Sexual Satisfaction and Self-Esteem

Little research has examined the role of physical activity in relationship functioning. Utilizing two heterosexual subsamples of 618 females and 155 males, results indicated that physical activity was positively correlated with sexual satisfaction and self-esteem for the female subsample, but was not significant for the male subsample. For both subsamples, although physical activity was not a significant unique predictor of relationship functioning in regression analyses, sexual satisfaction and self-esteem each significantly contributed the variance relationship functioning. The findings of this study increase our knowledge of mechanisms that impact sexual satisfaction, self-esteem, and physical activity among women, which in turn can potentially guide treatment planning and interventions.
Date: August 2018
Creator: Schumacher, Matthew Robert
System: The UNT Digital Library
The Role of Self-Criticism in Direct and Indirect Self-Harming Behaviors (open access)

The Role of Self-Criticism in Direct and Indirect Self-Harming Behaviors

Nonsuicidal self-injury (NSSI) is a form of direct self-harm that involves willful damage to bodily tissue without suicidal intent; it includes behaviors such as cutting, burning, carving, biting, scraping, and scratching of the skin, as well as hitting and skin and scab picking. Engagement in NSSI has been shown to relate to a host of maladaptive states and outcomes, including depression, anxiety, poor emotion regulation, and suicidal ideation and attempts. Socially sanctioned forms of body modification (e.g. tattoos and piercings) have received less attention as potential self-harm outlets, but have been posited to represent similar physical outlets of emotional pain. Indirect self-harm, in contrast, can include behaviors such as substance abuse, disordered eating, participation in abusive relationships, and sexual risk-taking. Extant literature suggests that self-harm in either form is associated with higher levels of self-criticism than healthy adults endorse. However, few studies have examined self-criticism in each of these self-harming subgroups. Female participants were recruited online using Amazon's Mechanical Turk. Results from the present study indicate that 1) direct self-harming individuals are considerably more self-critical than indirect self-harmers and control subjects, 2) those who engage in multiple forms of self-harm are more self-critical than those engaging in only one form, …
Date: August 2018
Creator: Tucker, Molly Salome
System: The UNT Digital Library
An Initial Validation of the Virtual Reality Stroop Task (VRST) in a Sample of OEF/OIF Veterans (open access)

An Initial Validation of the Virtual Reality Stroop Task (VRST) in a Sample of OEF/OIF Veterans

Currently, neuropsychologists rely on assessment instruments rooted in century old theory and technology to make evaluations of military personnel’s readiness to return-to-duty or return to their community. The present study sought to explore an alternative by evaluating the validity of a neuropsychological assessment presented within a virtual reality platform. The integration of a neuropsychological assessment into a cognitively and emotionally demanding virtual environment – reminiscent of a combat experience in Iraq – offers a more ecologically valid manner in which to evaluate the cognitive skills required in theater. U.S. military veterans’ (N = 50) performance on the Virtual Reality Stroop Task (VRST) was compared with performance on a paper-and-pencil, a computer adapted version of the Stroop task, and the subtests included in the Automated Neuropsychological Assessment Metrics-4 (ANAM4) TBI-MIL test battery. Results supported the validity of the VRST, indicating it demonstrates the typical Stroop effect pattern. The emotional salience of the VRST resulted in slowed reaction time compared to the ANAM Stroop. Further, the complex interference condition of the VRST offers opportunities for evaluation of exogenous and endogenous attentional processing. In the evaluation of threat, participants were noted to perform more accurately and more quickly in low threat versus high …
Date: August 2015
Creator: Johnson, Stephanie Feil
System: The UNT Digital Library
The Detection of Neuropsychological Malingering (open access)

The Detection of Neuropsychological Malingering

The present study compared the responses of a group of simulating malingerers who were offered a monetary incentive to feign symptoms of a head injury, with the responses of head injured groups both with and without litigation, a forensic parole group, and an honest-responding control group. The following six neuropsychological measures were utilized: Rey 15-Item Memory Test, Controlled Oral Word Association Test, Finger Oscillation Test, WAIS-R Neuropsychological Instrument (Vocabulary, Information, and Similarities subtests), Booklet Category Test, and Wisconsin Card Sorting Test. The statistical concepts of floor effect, performance curve, and magnitude of error were examined. Additionally, the statistical differences in the responses of the five groups were analyzed to determine cutting scores for use in distinguishing malingerers from nonmalingerers.
Date: August 2003
Creator: Liff, Christine D.
System: The UNT Digital Library

Universal Suicide Risk Screening in the Parkland Health and Hospital System: Evaluation of the Parkland Algorithm for Suicide Screening

Access: Use of this item is restricted to the UNT Community
Suicide is a significant public health issue in the US. Despite national and international prioritization since 1996, little definitive progress has been made in terms of identification and intervention in cases of elevated suicide risk. Forty percent of those who died by suicide attended an emergency department within a year of death. Therefore, universal suicide risk screening in emergency departments could prove a vital component to a national suicide prevention strategy. The present study empirically evaluated the universal suicide risk screening program recently implemented at Parkland Health and Hospital System. The sample consisted of patients over 18 years of age (N=333,855; Mage=42.7, 32% male) screened as part of routine clinical care from May 4th, 2015, through November 3rd, 2015. The Parkland Algorithm for Suicide Screening (PASS) is part of a clinical decision support system for responses to Columbia - Suicide Severity Rating Scale Clinical Practice Screener (C-SSRS) items, leading to an automated clinical response via three suicide risk stratification levels: no action for no risk identified, psychiatric social worker assessment for moderate risk identified, and psychiatrist/psychologist interview for high risk identified. The present study used receiver operating characteristic (ROC) curve analysis, which found the PASS predicted disposition (z=30.46, p<.001, AUC=.78, …
Date: August 2019
Creator: Goans, Christian
System: The UNT Digital Library
Hierarchical neuropsychological functioning in pediatric survivors of acute lymphoblastic leukemia. (open access)

Hierarchical neuropsychological functioning in pediatric survivors of acute lymphoblastic leukemia.

Acute lymphocytic leukemia (ALL) is one of the most common types of pediatric cancers. Improvements in treatment within the last 20 years have resulted in reduced mortality and a greater focus upon quality of life. Several researchers have documented neuropsychological impairments in children following treatment for ALL; however, there have not been any comparative studies documenting differences in neuropsychological functioning based upon treatment modality despite the documented effects of radiation therapy and combined radiation/chemotherapy upon the developing brain. In addition, past studies have focused on unitary measures, ignoring the hierarchical relationship between basic cognitive functions and more abstract skills. This study examined the neuropsychological functioning of 81 children who were treated for ALL at a metropolitan children's hospital. All children were tested a minimum of two years after the final treatment session and were administered the NEPSY. Results do not support any interactions or main effects with the exception of the age of the child at diagnosis. Children diagnosed prior to the age of 5 showed greater impairments on tasks measuring attention, memory, and visuospatial reasoning in comparison to peers diagnosed after age 6.
Date: August 2007
Creator: Larery, Angela R. D.
System: The UNT Digital Library