Delayed hypersensitivity can be conferred passively to normal animals. There exists a period when whole peritoneal exudate cells will passively confer delayed sensitivity, but a sonic extract from them will not; however, after a few more days, both whole cells and sonic extracts could transfer sensitivity. This investigation was undertaken to study the differences in cells collected at two different time intervals after initial sensitization of guinea pigs with 1-fluoro-2,4-dinitrobenzene.

The major purpose of this investigation was to determine the effect of carbon monoxide on the development of various morphological phases of a single isolate of the aquatic streptomycetes and to elucidate the physiological differences between terminal respiration in the primary and secondary stages. A secondary purpose was to repeat the work of Michael Lee Higgins involving the effect of anaerobiosis on the growth of the organism.

Having considered the data collected thus far concerning immediate and delayed hypersensitivity reactions in the mouse, the experimentation following is devised essentially to follow the pattern of Crowle in the production and testing for immunoresponse. Instead of using the normal solvent, that is, acetone, this work is also intended to partially evaluated the use of dimethyl sulfoxide as a solvent for the contact allergin, dinitroflurobenzene.

The induction of phenylketonuria in mice through the use of excess dietary phenylalanine is an area in which limited research has been done. This study intends to pursue further work in this area, more specifically, to study the effects of excess dietary phenylalanine and the phenylalanine analogue A.P.B.A. (2-amino-3-phenyl butanoic acid) (7) on brain serotonin and brain norepinephrine. In addition, the effects of these two compounds on the incidence of audiogenic seizures will be explored.

The aim of this study is to determine the changes in respiration in tissues from specific brain areas X-irradiated in vitro using a direct monometric procedure also to determine the differences in radiosensitivity of specific areas in the brain as reflected by changes in oxygen uptake and to shed some light on the nature of the biochemical lesions in nerve tissues brought about by ionizing radiation.

This research is concerned specifically with the growth of two selected algae found surviving in chlorinated water in outdoor swimming pools. Unialgal cultures were used to determine the free chlorine residuals that these algae were able to tolerate.

The purpose of this study, therefore, was threefold in nature: (1) to determine the effects of x-irradiation on the influx and efflux of potassium in compound nerve fibers (2) to attempt to relate the radiation-induced changes in electrical activity with potassium flux and (3) to use the information obtained to gain insight into the possible cellular site (s) of radiation insult to compound nerves.

The purpose of this investigation is to determine if differences exist between four inbred strains of mice in susceptibility to the drug thalidomide.