Weekly newspaper from Clifton, Texas that includes local, state, and national news along with advertising.

Weekly Jewish newspaper from Fort Worth, Texas that includes local, state, and national news along with extensive advertising.

The basement membrane (BM) extracellular matrix induces differentiation and suppresses apoptosis in mammary epithelial cells, whereas cells lacking BM lose their differentiated phenotype and undergo apoptosis. Addition of purified BM components, which are known to induce {beta}-casein expression, did not prevent apoptosis, indicating that a more complex BM was necessary. A comparison of culture conditions where apoptosis would or would not occur allowed us to relate inhibition of apoptosis to a complete withdrawal from the cell cycle, which was observed only when cells acquired a three-dimensional alveolar structure in response to BM. In the absence of this morphology, both the G1 cyclin kinase inhibitor p21/WAF-I and positive proliferative signals including c-myc and cyclin Dl were expressed and the retinoblastoma protein (Rb) continued to be hyperphosphorylated. When we overexpressed either c-myc in quiescent cells or p21 when cells were still cycling, apoptosis was induced. In the absence of three-dimensional alveolar structures, mammary epithelial cells secrete a number of factors including transforming growth factor a and tenascin, which when added exogenously to quiescent cells induced expression of c-myc and interleukin-{beta}1-converting enzyme (ICE) mRNA and led to apoptosis. These experiments demonstrate that a correct tissue architecture is crucial for long-range homeostasis, suppression of …

Semiweekly newspaper from Pawhuska, Oklahoma that includes local, state, and national news along with advertising.

Semiweekly newspaper from Pawhuska, Oklahoma that includes local, state, and national news along with advertising.

Weekly newspaper from Tulia, Texas that includes local, state and national news along with extensive advertising.

Weekly newspaper from Sanger, Texas that includes local, state, and national news along with extensive advertising.

Daily newspaper from Sulphur Springs, Texas that includes local, state, and national news along with advertising.

Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.

Weekly newspaper from Teague, Texas that includes local, state, and national news along with advertising.

Weekly newspaper from Tulsa, Oklahoma that includes local, state, and national news along with advertising.

Weekly newspaper from Castroville, Texas that includes local, state, and national news along with extensive advertising.

Daily newspaper from Port Lavaca, Texas that includes local, state, and national news along with advertising.

Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.

Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.

Semiweekly newspaper from Levelland, Texas that includes local, state, and national news along with advertising.

Daily newspaper from Chickasha, Oklahoma that includes local, state, and national news along with advertising.

Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.

Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.