A large number of GE techniques can be adapted from other microorganisms to biothreat bacteria and viruses. Detection of GE in a microorganism increases in difficulty as the size of the genetic change decreases. In addition to the size of the engineered change, the consensus genomic sequence of the microorganism can impact the difficulty of detecting an engineered change in genomes that are highly variable from strain to strain. This problem will require comprehensive databases of whole genome sequences for more genetically variable biothreat bacteria and viruses. Preliminary work with microarrays for detecting synthetic elements or virulence genes and analytic bioinformatic approaches for whole genome sequence comparison to detect genetic engineering show promise for attacking this difficult problem but a large amount of future work remains.

We report a systematic neutron diffraction study on the coexistence of long-range magnetic order and superconductivity in heavy fermion compounds CeRhl-,M,Ins (M=Ir,Co). In addition to the incommensurate antiferromagnetic component in pure CeRhIn5, new type of antiferromagnetic component is found to concur with appearance of superconductivity in the Ir and Co alloy series. There is no detectable effect of the superconducting transition on magnetic order parameters. We compare those results with similar studies we performed on CeRhIn:, under pressure. We also discuss possible theoretical scenarios.

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