>Thesis. The translocation dynamics of /sup 239/Pu(NO/sub 3/)/sub 4/ and /sup 239/PuO/sub 2/ from ulated puncture wounds in the paws of beagle dogs were studied. The difference between the more soluble Pu(NO/sub 3/)/sub 4/ form the insoluble high fired PuO/sub 2 particles was assumed to bring about highly differing translocation dynamics from the wound site, through lymphatic channels into the system's circulation and to organs of deposition and of excretion. There was rapid movement of Pu from the paw to the first major lymph node with a resulting buildup and regression pattern for activity within the node. Differential translocation, concentration, retention, and excretion of Pu and Am were demonstrated with both chemical forms. The effectiveness of DTPA administration for Pu removal from the body was dependent on the chemical form of the Pu contaminant. ( CH)