In my study, I examine if and how Sandra Oh’s portrayal of Dr. Cristina Yang in Grey’s Anatomy, a primetime network drama, reifies or resists U.S. mediated stereotypes of Asian American females. I situate my intercultural study in an interpretive paradigm because I am want to explore how the evolving characteristics of existing the Asian American female mediated stereotype as they influence Asian American female identity. Additionally, I trace the historical development of Asian and Asian American stereotypes yellow peril to the model minority; and from Dragon Lady, Lotus Blossom, Geisha, and Suzie Wong. From my textual analysis, I suggest that when portrayals simultaneously reify and resist characteristics of existing Asian American stereotypes, they may help to breakdown perceived binaries of existing Asian and Asian American stereotypes.