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Biological (molecular and cellular) markers of toxicity. Final report, September 15, 1988--September 14, 1991
Several molecular and cellular markers of genotoxicity were adapted for measurement in the Medaka (Oryzias latipes), and were used to describe the effects of treatment of the organism with diethylnitrosamine (DEN). NO{sup 6}-ethyl guanine adducts were detected, and a slight statistically significant, increase in DNA strand breaks was observed. These results are consistent with the hypothesis that prolonged exposure to high levels of DEN induced alkyltransferase activity which enzymatically removes any O{sup 6}-ethyl guanine adducts but does not result in strand breaks or hypomethylation of the DNA such as might be expected from excision repair of chemically modified DNA. Following a five week continuous DEN exposure with 100 percent renewal of DEN-water every third day, the F values (DNA double strandedness) increased considerably and to similar extent in fish exposed to 25, 50, and 100 ppM DEN. This has been observed also in medaka exposed to BaP.
Date:
December 15, 1991
Creator:
Shugart, L. R.; D`Surney, S. J.; Gettys-Hull, C. & Greeley, M. S. Jr.
Object Type:
Report
System:
The UNT Digital Library
Biological (molecular and cellular) markers of toxicity
Several molecular and cellular markers of genotoxicity were adapted for measurement in the Medaka (Oryzias latipes), and were used to describe the effects of treatment of the organism with diethylnitrosamine (DEN). NO{sup 6}-ethyl guanine adducts were detected, and a slight statistically significant, increase in DNA strand breaks was observed. These results are consistent with the hypothesis that prolonged exposure to high levels of DEN induced alkyltransferase activity which enzymatically removes any O{sup 6}-ethyl guanine adducts but does not result in strand breaks or hypomethylation of the DNA such as might be expected from excision repair of chemically modified DNA. Following a five week continuous DEN exposure with 100 percent renewal of DEN-water every third day, the F values (DNA double strandedness) increased considerably and to similar extent in fish exposed to 25, 50, and 100 ppM DEN. This has been observed also in medaka exposed to BaP.
Date:
December 15, 1991
Creator:
Shugart, L. R.; D'Surney, S. J.; Gettys-Hull, C. & Greeley, M. S., Jr.
Object Type:
Report
System:
The UNT Digital Library
Altus Times (Altus, Okla.), Vol. 90, No. 262, Ed. 1 Tuesday, January 15, 1991
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
January 15, 1991
Creator:
Lomenick, Rick
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 91, No. 158, Ed. 1 Sunday, September 15, 1991
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
September 15, 1991
Creator:
Lomenick, Rick
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Muskogee - Okmulgee Oklahoma Eagle (Muskogee and Okmulgee, Okla.), Vol. 19, No. 16, Ed. 1 Thursday, August 15, 1991
Weekly newspaper from Muskogee and Okmulgee, Oklahoma that includes local, state, and national news along with advertising.
Date:
August 15, 1991
Creator:
unknown
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Tulia Herald (Tulia, Tex.), Vol. 83, No. 33, Ed. 1 Thursday, August 15, 1991
Weekly newspaper from Tulia, Texas that includes local, state and national news along with extensive advertising.
Date:
August 15, 1991
Creator:
Reynolds, Jim
Object Type:
Newspaper
System:
The Portal to Texas History
Hilltop Views (Austin, Tex.), Vol. 5, No. 12, Ed. 1 Monday, April 15, 1991
Biweekly student newspaper from St. Edward's University in Austin, Texas that includes news and information of interest to the college community along with advertising.
Date:
April 15, 1991
Creator:
unknown
Object Type:
Newspaper
System:
The Portal to Texas History
The Wynnewood Gazette (Wynnewood, Okla.), Vol. 89, No. 18, Ed. 1 Thursday, August 15, 1991
Weekly newspaper from Wynnewood, Oklahoma that includes local, state, and national news along with advertising.
Date:
August 15, 1991
Creator:
Golden, Larry D.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Sapulpa Daily Herald (Sapulpa, Okla.), Vol. 77, No. 156, Ed. 1 Friday, March 15, 1991
Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.
Date:
March 15, 1991
Creator:
Lake, Charles S.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Mannford Eagle (Mannford, Okla.), Vol. 11, No. 11, Ed. 1 Wednesday, May 15, 1991
Weekly newspaper from Mannford, Oklahoma that includes local, state, and national news along with advertising.
Date:
May 15, 1991
Creator:
Cranke, Jay
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Sanger Courier (Sanger, Tex.), Vol. 92, No. 33, Ed. 1 Thursday, August 15, 1991
Weekly newspaper from Sanger, Texas that includes local, state, and national news along with extensive advertising.
Date:
August 15, 1991
Creator:
unknown
Object Type:
Newspaper
System:
The Portal to Texas History
The Dublin Citizen (Dublin, Tex.), Vol. 1, No. 49, Ed. 1 Thursday, August 15, 1991
Weekly newspaper from Dublin, Texas that includes local, state, and national news along with advertising.
Date:
August 15, 1991
Creator:
Wright, Karen
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 69, No. 142, Ed. 1 Monday, April 15, 1991
Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
April 15, 1991
Creator:
Brown, Leon
Object Type:
Newspaper
System:
The Portal to Texas History
The Gayly Oklahoman (Oklahoma City, Okla.), Vol. 9, No. 24, Ed. 1 Sunday, December 15, 1991
Semi-monthly newspaper from Oklahoma City, Oklahoma that includes local, state, and national news and advertising of interest to the Lesbian, Gay, Bisexual, and Transgender (LGBT) community.
Date:
December 15, 1991
Creator:
Shaffer, Ron & Hawkins, Don
Object Type:
Newspaper
System:
The UNT Digital Library
The Wave (Port Lavaca, Tex.), Vol. 100, No. 140, Ed. 1 Monday, April 15, 1991
Daily newspaper from Port Lavaca, Texas that includes local, state, and national news along with advertising.
Date:
April 15, 1991
Creator:
Bales, Steve & Fortney, Paul, Jr.
Object Type:
Newspaper
System:
The Portal to Texas History
The Sealy News (Sealy, Tex.), Vol. 104, No. 23, Ed. 1 Thursday, August 15, 1991
Weekly newspaper from Sealy, Texas that includes local, state, and national news along with advertising.
Date:
August 15, 1991
Creator:
Petrusek, Wilma
Object Type:
Newspaper
System:
The Portal to Texas History
Polk County Enterprise (Livingston, Tex.), Vol. 109, No. 100, Ed. 1 Sunday, December 15, 1991
Semi-weekly newspaper from Livingston, Texas that includes local, state and national news along with advertising.
Date:
December 15, 1991
Creator:
White, Barbara
Object Type:
Newspaper
System:
The Portal to Texas History
The Oklahoma Eagle (Tulsa, Okla.), Vol. 70, No. 31, Ed. 1 Thursday, August 15, 1991
Weekly newspaper from Tulsa, Oklahoma that includes local, state, and national news along with advertising.
Date:
August 15, 1991
Creator:
unknown
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Levelland and Hockley County News-Press (Levelland, Tex.), Vol. 13, No. 74, Ed. 1 Sunday, December 15, 1991
Semiweekly newspaper from Levelland, Texas that includes local, state, and national news along with advertising.
Date:
December 15, 1991
Creator:
unknown
Object Type:
Newspaper
System:
The Portal to Texas History
The Optimist (Abilene, Tex.), Vol. 79, No. 37, Ed. 1, Friday, February 15, 1991
Weekly student newspaper from Abilene Christian University in Abilene, Texas that includes local, state and campus news along with advertising.
Date:
February 15, 1991
Creator:
unknown
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 69, No. 92, Ed. 1 Friday, February 15, 1991
Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
February 15, 1991
Creator:
Brown, Leon
Object Type:
Newspaper
System:
The Portal to Texas History
The Seminole Sentinel (Seminole, Tex.), Vol. 84, No. 92, Ed. 1 Sunday, September 15, 1991
Semiweekly newspaper from Seminole, Texas that includes local, state and national news along with extensive advertising.
Date:
September 15, 1991
Creator:
Fisher, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Comanche Chief (Comanche, Tex.), Vol. 119, No. 13, Ed. 1 Thursday, August 15, 1991
Weekly newspaper from Comanche, Texas that includes local, state, and national news along with advertising.
Date:
August 15, 1991
Creator:
Wilkerson, James C., III
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 70, No. 38, Ed. 1 Sunday, December 15, 1991
Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
December 15, 1991
Creator:
Brown, Leon
Object Type:
Newspaper
System:
The Portal to Texas History